DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Lsamp

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_038944182.1	Gene:	Lsamp / 29561	RGDID:	71102	Length:	378	Species:	Rattus norvegicus

Alignment Length:	346	Identity:	77/346 - (22%)
Similarity:	131/346 - (37%)	Gaps:	61/346 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   631 NSPPV---IEPFKFPK---------------NLQEGGRAQITCAVSSGDMPIYFSWKK------- 670
            |.||.   :.|...|.               .:::|..|.:.|.|...:..:  :|..
  Rat    28 NQPPAEVNLSPITIPGLPVRSVDFNRGTDNITVRQGDTAILRCVVEDKNSKV--AWLNRSGIIFA 90

  Fly   671 --DDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYE 733
              |..|:...:::.::....|||.:.| :.....|.|||..............|.|:|.|:....
  Rat    91 GHDKWSLDPRVELEKRHALEYSLRIQK-VDVYDEGSYTCSVQTQHEPKTSQVYLIVQVPPKISNI 154

  Fly   734 PMDTAIMLGNTISINCEAEGYPIPTITW---------FKGQGKGSKDFKPLSMRNHSLLLNLATD 789
            ..|..:..|:.:::.|.|.|.|.|.|||         |:|:            ..:..:|.: |.
  Rat   155 SSDVTVNEGSNVTLVCMANGRPEPVITWRHLTPLGREFEGE------------EEYLEILGI-TR 206

  Fly   790 NDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQ 854
            ...|.|.|:|.||:.:...|.:::.||.|....:|..| .:......:|.|.|.........|.:
  Rat   207 EQSGKYECKAANEVSSADVKQVKVTVNYPPTITESKSN-EATTGRQASLKCEASAVPAPDFEWYR 270

  Fly   855 NNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDT 919
            ::.||:..|.    .|:|:.:| .|.||:.:......|.|.|:|.|..|.....:.|..:..|..
  Rat   271 DDTRINSANG----LEIKSTEG-QSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFKRVLPTV 330

  Fly   920 PSHLEIFEVGSRTVKLSWRRP 940
            |..::  |:|: ||....:.|
  Rat   331 PHPIQ--EIGT-TVHFKQKGP 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352	19/116 (16%)
		ig	645..712	CDD:278476	15/75 (20%)
		IG_like	734..815	CDD:214653	21/89 (24%)
		Ig	745..815	CDD:299845	19/78 (24%)
		I-set	820..913	CDD:254352	22/92 (24%)
		Ig	838..920	CDD:299845	21/81 (26%)
		FN3	917..1033	CDD:238020	7/24 (29%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Lsamp	XP_038944182.1	Ig	55..145	CDD:416386	16/92 (17%)
		FR1	55..71	CDD:409353	2/15 (13%)
		Ig strand A'	56..62	CDD:409353	0/5 (0%)
		Ig strand B	64..72	CDD:409353	2/7 (29%)
		CDR1	72..76	CDD:409353	1/3 (33%)
		FR2	77..84	CDD:409353	1/8 (13%)
		Ig strand C	77..83	CDD:409353	1/7 (14%)
		CDR2	85..95	CDD:409353	1/9 (11%)
		Ig strand C'	87..90	CDD:409353	0/2 (0%)
		Ig strand C'	92..95	CDD:409353	1/2 (50%)
		FR3	96..131	CDD:409353	9/35 (26%)
		Ig strand D	100..107	CDD:409353	0/6 (0%)
		Ig strand E	110..116	CDD:409353	3/5 (60%)
		Ig strand F	123..131	CDD:409353	4/7 (57%)
		CDR3	132..136	CDD:409353	0/3 (0%)
		Ig strand G	136..145	CDD:409353	1/8 (13%)
		FR4	138..145	CDD:409353	1/6 (17%)
		Ig_3	148..218	CDD:404760	19/82 (23%)
		Ig strand A'	155..160	CDD:409353	1/4 (25%)
		Ig strand B	166..173	CDD:409353	1/6 (17%)
		Ig strand C	179..184	CDD:409353	3/4 (75%)
		Ig strand D	190..193	CDD:409353	0/2 (0%)
		Ig strand E	197..203	CDD:409353	0/5 (0%)
		Ig strand F	210..217	CDD:409353	3/6 (50%)
		Ig strand G	224..232	CDD:409353	1/7 (14%)
		Ig_3	235..311	CDD:404760	20/81 (25%)
		Ig strand B	252..256	CDD:409353	1/3 (33%)
		Ig strand C	265..269	CDD:409353	0/3 (0%)
		Ig strand E	290..294	CDD:409353	2/3 (67%)
		Ig strand F	304..309	CDD:409353	2/4 (50%)
		Ig strand G	318..321	CDD:409353	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810