DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Hmcn1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001258221.1	Gene:	Hmcn1 / 289094	RGDID:	1564772	Length:	5635	Species:	Rattus norvegicus

Alignment Length:	2137	Identity:	468/2137 - (21%)
Similarity:	764/2137 - (35%)	Gaps:	619/2137 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLGALLLAVLATPLLAT----------SGLRVPTFLLEP-APRLLFGNDTGAQVT--------C 60
            :|.|..:||:.:..:..|          :|.:...|.|.. ||..:.|.:....|.        |
  Rat  2061 VLSGGRILALTSAQMSDTGRYTCVAVNAAGEKQRDFDLRVYAPPNIMGEEQNVSVLISQTVELFC 2125

  Fly    61 TAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEA------TYRCRAS 119
            .:...|||.:.| .:||....:.||| .||.||::..           :.:|      .|.|.|:
  Rat  2126 QSDAVPPPTLMW-FKDGRPLLKRPGL-SISENGSVLM-----------IEDAQAGDTGRYTCEAT 2177

  Fly   120 NEAGTVLSRNVQVHAVVRRQFHVHVENTEVYL--GNSALIKCAIPEYVRPYVRVASWHRGEEILL 182
            |.||.. .:|..|:..|....:...|..::..  ||...:.|.......|.:   :|.:...::
  Rat  2178 NVAGKT-EKNYNVNIWVPPSIYGSDELVQLTAIEGNLITLLCESSGIPPPNL---TWKKKGSLV- 2237

  Fly   183 PDLSDVAGRYVVLAASGDLYVRSVRSED-GLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAP 246
              |:|.|||..:|:....|.:......| ||  ::|:.:|.....::..:   ||| .:..::|.
  Rat  2238 --LADAAGRVHILSGGRRLQISIAEKADAGL--YTCVASNVAGIAKKEYN---LQV-YIRPSIAN 2294

  Fly   247 RTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRV-ILSR-TLLLIKN 309
            ..:.:|  ||.|.||..:.|.|.:||.|.|..||  :.|..   |:...:.| ||.. .:|.:||
  Rat  2295 SGSHRP--EITVIRGRSISLECEVQGIPQPTVTW--MKDGR---PLSKGKGVEILDEGRVLQLKN 2352

  Fly   310 ADERDAGKWICQASNQFG--EQRIEIRLSVNSYVSVHILPQVQIVNSG----------GTANFNC 362
            ....|.|:::|.|.|..|  ::|.::        |||:.|.: |.|.|          .:.:..|
  Rat  2353 VHVSDTGRYVCVAVNVAGMTDKRYDL--------SVHVPPSI-IGNHGVPENISVVEKSSVSLTC 2408

  Fly   363 TTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLL-VQNVGRRDRGVYQCLVENQRASA 426
            ..:|..:.:|.||.:|.|:...:       :::.||...:| :......|.|.|.|:|.|.....
  Rat  2409 EASGIPLPSITWLKDGWPVSLGS-------SVKILSGGRMLRLMQTRPEDAGQYTCIVRNAAGED 2466

  Fly   427 QAMAELKLGDTVPELIY---TFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRF 488
            :.|..|.:  .||..|.   |..:..::....::|.|...|:|.||..|..|.|.:.:..:||..
  Rat  2467 RKMFGLSV--LVPPHIVGDNTLEDIKIKEKQSVTLTCEVRGNPVPQITWHKDGQLLQEDEVHHMM 2529

  Fly   489 AIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAI----GPIK 549
            :.|:|:.::...:||.          |.|.|:|||..|....|..|||:..|.:..:    .|
  Rat  2530 SGGRFLQITNAQVSHT----------GRYTCLASNIAGDKSKSFSLNVFVSPTIAGVDSDGSP-- 2582

  Fly   550 AVAGEDIIV--------HCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRD 606
                ||:||        .|....||...|.|.|....|.:|.:  |..:..|..|.|.|.:.. :
  Rat  2583 ----EDVIVILNSPTSLVCEAYSYPPATITWFKDGAPLESSRN--LRILPGGRTLQILNAQED-N 2640

  Fly   607 QGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKF------PKNLQEGGRAQITCAVSSGDMP-I 664
            .|.|:|:..:.|||..:. .::.|..||:|:....      ||.::....:.:|....:..:| .
  Rat  2641 AGRYSCVATNEAGEMIKH-YEVKVYIPPIIKKGDLLGTGLSPKEVKIRVNSSLTLECEAYAIPSA 2704

  Fly   665 YFSWKKDDSSIPSS--LQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVA 727
            ...|.||...:.|.  :.|.|...    .|..|:.....:|:|||.|||.|.:.....::.::|.
  Rat  2705 SLRWYKDGQPLKSDHHVNIAENGH----TLQIKEAQISDTGRYTCVASNLAGEDELDFDVNIQVP 2765

  Fly   728 PR----WRYEPM-DTA-------IMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNH 780
            |.    |....| ||.       :::.|.||::||....|.||:||:       ||.:||:..:.
  Rat  2766 PSFQKLWEIGNMLDTGRSGEAKDVIINNPISLHCETNAAPPPTLTWY-------KDGRPLTSSDR 2823

  Fly   781 SLLL--------NLATDNDEGYYMCQATNEIG--------------------AGLKKTIRINVNE 817
            .|:|        ..|...|.|.|.|.|.||.|                    :.|.:.:.:.||:
  Rat  2824 VLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDIHVLLPPVIKGANSDLPEEVTVLVNK 2888

  Fly   818 PARFEQSA------RNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKG 876
            .|:.|.|:      ||...:...|:..|.|.|         ..::||:
  Rat  2889 SAQMECSSSGSPAPRNFWQKDGQPLLEDEHHK---------FLSDGRV----------------- 2927

  Fly   877 VDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDT--PSHLEIFEVG----SRTVKL 935
                |.|.::...|:|.|.|:|||..|.|::...|.|...|..  |:|..:..|.    |.|.::
  Rat  2928 ----LQILNAQITDTGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPNHEHLSVVVNHFISLTCEV 2988

  Fly   936 SWRRPFDGNSPVLSYLVQYQALK------------YLQSHGSLAAAGGDWNGHVIN--------V 980
            |...|     |.|::|...|.:|            .||...:..:.||::....||        |
  Rat  2989 SGFPP-----PDLNWLKNEQPIKPNTNVLIVPGGRTLQIIRAKVSDGGEYTCVAINQAGESKKKV 3048

  Fly   981 SLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNV 1045
            || :..:..|......||..:..:...|:..:      |.|.:|....::..::........|||
  Rat  3049 SL-TVHVPPSIKDHGSESLSIVNVREGTSVSL------ECESNAVPPPVITWSKNGRMIPDSSNV 3106

  Fly  1046 QVQTGGESELIVTWQIPPRESWNGELIGYTVN-CSEEKQNINFISVVNSSLKSTIVSGWATTKAT 1109
            .:.|||:...|...::..    .|:.:...:| ...:.:|.:    :|..:..||
  Rat  3107 AILTGGQMLHIRRAEVAD----TGQYVCRAINVAGRDDKNFH----LNVYVPPTI---------- 3153

  Fly  1110 LRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLE---- 1170
                                 .||.:..|..|.:.      |..:.|.|.......|:||:
  Rat  3154 ---------------------EGPETEVIVETMSN------PVTLTCDATGIPPPTITWLKNHKP 3191

  Fly  1171 ----PPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTAT 1231
                .||:.|  |:.|              .:||:|.|          |.:::..:...:|....
  Rat  3192 IENSDPLEAH--ILSG--------------GSKLQIAR----------LQRSNRGNYTCVASNME 3230

  Fly  1232 GDGLASHPLFCQTDDDVPDAPAAIKAAALTADSI------------LISWLTPKNRNG--IISHY 1282
            |....::.|..|....|..|....:.:.|..:::            .:.||    |:|  |:|
  Rat  3231 GKAQKNYILSIQVPPSVAGAEVPSEVSVLLGENVELVCDADGIPIPRLQWL----RDGKPIVS-- 3289

  Fly  1283 TVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNT 1347
                        .:|..|||..:|..:.. .|:|. :.|.::...|:...||.:....:    |.
  Rat  3290 ------------GETERVRVTTDGSTLNI-YRALT-SDMGKYTCVATNPAGEEDRIFNL----NV 3336

  Fly  1348 RAPARIASFGQVVRK---AVGTGLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVTNEGN-LKIH 1408
            ..|.:|....:...|   .|.|.|.:||.|.|.|.|:..||....|:..|....:.:.|. ::|.
  Rat  3337 YVPPKIRGNKEEAEKLMALVDTSLNIECKATGTPPPQISWLKNGLPLPISSHIRLLSAGQAIRIV 3401

  Fly  1409 RVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPS------APQIIVQYASADSIRVSWDAPDDGG 1467
            |.:.|....|||.|:|..|.|..:|.:....||:      ..:|.:...|:.|:....|     |
  Rat  3402 RAQVSDVAVYTCVASNRAGIDSKRYSLQVFVPPNMDNAMGTEEITLVKGSSTSMTCFTD-----G 3461

  Fly  1468 APLQGYTISYHTAGESWSITELLPENNAFTISG-LKCGNQ-YIIKMSAHNMVGSG----VASEEI 1526
            ||         |...||     |.:.....:.. |..|.| .::::...:...:|    |||.|.
  Rat  3462 AP---------TPSMSW-----LRDGQPLALDAHLTIGTQGMVLQLIKADTEDTGKYTCVASNEA 3512

  Fly  1527 NVWTKG-----------KASQAPNANELIATNATCVNLKLS-----------SWQ---------- 1559
            ...:|.           ..|:.|....:|..|.    |:||           ||.
  Rat  3513 GEVSKHFVLKVLEPPHINGSEGPGEVSVIVNNP----LELSCIASGIPAPKISWMKDGRPFLQTE 3573

  Fly  1560 -----NGGCSIHHFSIEHRPLGDIRWTVVTS------------------DISNAEE--------N 1593
                 .||..:...|.:....|  |:|.:.|                  :|:..:|        |
  Rat  3574 QVQTLEGGAILRVSSAQVEDTG--RYTCLASSPAGDDDKEYLVRVHVPPNIAGVDEAQDFTVLRN 3636

  Fly  1594 RENLIFC--DFLP---AKWYQ-------------------LRIS-------------ATNDAGKT 1621
            |:..:.|  |.:|   ..|.:                   |:|:             |:|.||||
  Rat  3637 RQVTLECKSDAVPPPVIMWLKNGEQLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKT 3701

  Fly  1622 TEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTIK 1686
            |..: ..|.|:      |||:             |..|.|           ::|:...:|||.
  Rat  3702 TREF-ILTVNV------PPSI-------------SGGPQS-----------LVTLLNKSIALE-- 3733

  Fly  1687 HRRTLCGPIAEGYESRTLPGDYKED------------------------HENRRNQQVYSASPVK 1727
                 |  :|||..|..:  .:::|                        |.....:.:..|:.|.
  Rat  3734 -----C--LAEGVPSPRI--TWRKDGVVLAESHARYSILENGFLHIQSAHITDTGRYLCMATNVA 3789

  Fly  1728 TVDKGNESEMYEISPYATFSVNGGRTGAPAKTPTRAVAAQTPL--------DYTMQFKTFGHPEG 1784
            ..|:........:.|    |:..|.|..     |..|..||.|        ..::.::..||...
  Rat  3790 GTDRRRIDLQVHVPP----SIAAGPTNV-----TVTVNVQTTLACEATGIPKPSINWRKDGHLLN 3845

  Fly  1785 ENLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTEDESTLSKSMTIVAGSQAGHSKKS 1841
            .:.|..:|.|| |||...:.|.|.           :.|.|...|:.  |.||..|::
  Rat  3846 VDQNQNSYRLL-SSGSLIIISPSV-----------DDTASYECTVT--SDAGEDKRT 3888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	23/90 (26%)
		Ig	56..125	CDD:143165	22/82 (27%)
		I-set	246..337	CDD:254352	29/94 (31%)
		Ig	264..334	CDD:143165	23/73 (32%)
		I-set	345..433	CDD:254352	21/98 (21%)
		Ig	358..431	CDD:143165	17/73 (23%)
		Ig	456..533	CDD:143165	23/76 (30%)
		IGc2	553..619	CDD:197706	20/73 (27%)
		I-set	634..724	CDD:254352	22/98 (22%)
		ig	645..712	CDD:278476	16/69 (23%)
		IG_like	734..815	CDD:214653	29/116 (25%)
		Ig	745..815	CDD:299845	25/97 (26%)
		I-set	820..913	CDD:254352	22/98 (22%)
		Ig	838..920	CDD:299845	19/83 (23%)
		FN3	917..1033	CDD:238020	29/141 (21%)
		FN3	1040..1142	CDD:238020	16/102 (16%)
		fn3	1150..1237	CDD:278470	18/94 (19%)
		FN3	1263..1345	CDD:238020	17/95 (18%)
		Ig	1350..1436	CDD:299845	28/89 (31%)
		IG_like	1358..1436	CDD:214653	26/81 (32%)
		FN3	1441..1530	CDD:238020	20/100 (20%)
		FN3	1542..1620	CDD:238020	27/166 (16%)
Hmcn1	NP_001258221.1	VWA_2	42..212	CDD:290253
		I-set	520..608	CDD:254352
		ig	524..606	CDD:278476
		I-set	612..696	CDD:254352
		Ig	626..696	CDD:299845
		I-set	702..789	CDD:254352
		Ig	716..789	CDD:299845
		Ig	792..884	CDD:299845
		IG_like	799..884	CDD:214653
		I-set	890..977	CDD:254352
		IGc2	903..967	CDD:197706
		Ig	980..1071	CDD:299845
		IG	994..1068	CDD:214652
		I-set	1085..1167	CDD:254352
		Ig	1086..1167	CDD:299845
		I-set	1171..1258	CDD:254352
		Ig	1188..1255	CDD:143165
		Ig	1261..1357	CDD:299845
		I-set	1267..1355	CDD:254352
		I-set	1368..1448	CDD:254352
		Ig	1380..1448	CDD:299845
		IG	1460..1541	CDD:214652
		IGc2	1470..1532	CDD:197706
		IG_like	1557..1633	CDD:214653
		Ig	1565..1632	CDD:143165
		I-set	1645..1729	CDD:254352
		Ig	1648..1725	CDD:299845
		I-set	1752..1822	CDD:254352
		Ig	1754..1815	CDD:299845
		IG	1834..1915	CDD:214652
		IGc2	1843..1905	CDD:197706
		IG_like	1929..2008	CDD:214653
		IGc2	1935..1998	CDD:197706
		I-set	2012..2100	CDD:254352	8/38 (21%)
		Ig	2021..2092	CDD:299845	6/30 (20%)
		I-set	2111..2191	CDD:254352	24/93 (26%)
		IGc2	2119..2181	CDD:197706	19/74 (26%)
		I-set	2203..2286	CDD:254352	18/93 (19%)
		IGc2	2210..2276	CDD:197706	17/73 (23%)
		Ig	2299..2380	CDD:299845	29/95 (31%)
		IG_like	2300..2380	CDD:214653	29/94 (31%)
		I-set	2392..2474	CDD:254352	18/88 (20%)
		IGc2	2400..2464	CDD:197706	16/70 (23%)
		I-set	2478..2567	CDD:254352	26/98 (27%)
		IGc2	2493..2557	CDD:197706	21/73 (29%)
		I-set	2582..2663	CDD:254352	24/90 (27%)
		IGc2	2594..2653	CDD:197706	16/61 (26%)
		I-set	2681..2762	CDD:254352	20/84 (24%)
		Ig	2688..2762	CDD:299845	18/77 (23%)
		IG_like	2789..2865	CDD:214653	25/82 (30%)
		IGc2	2791..2855	CDD:197706	24/70 (34%)
		I-set	2879..2960	CDD:254352	25/110 (23%)
		Ig	2879..2950	CDD:299845	22/100 (22%)
		IG	2972..3052	CDD:214652	19/85 (22%)
		IGc2	2982..3042	CDD:197706	15/64 (23%)
		IG	3069..3147	CDD:214652	14/91 (15%)
		IGc2	3073..3137	CDD:197706	13/73 (18%)
		IG	3150..3241	CDD:214652	25/153 (16%)
		Ig	3150..3241	CDD:299845	25/153 (16%)
		Ig	3244..3338	CDD:299845	21/117 (18%)
		I-set	3252..3336	CDD:254352	18/107 (17%)
		I-set	3354..3430	CDD:254352	25/75 (33%)
		IGc2	3357..3420	CDD:197706	21/62 (34%)
		Ig	3433..3523	CDD:299845	22/108 (20%)
IG_like	3443..3523	CDD:214653	20/98 (20%)
IG_like	3535..3616	CDD:214653	15/86 (17%)
IGc2	3543..3606	CDD:197706	13/68 (19%)
I-set	3629..3709	CDD:254352	15/80 (19%)
IGc2	3636..3699	CDD:197706	10/62 (16%)
I-set	3713..3800	CDD:254352	19/121 (16%)
Ig	3719..3795	CDD:299845	16/97 (16%)
Ig	3823..3889	CDD:143165	19/80 (24%)
I-set	3897..3984	CDD:254352
IGc2	3913..3974	CDD:197706
Ig	3993..4066	CDD:299845
IG_like	3994..4075	CDD:214653
IG_like	4085..4165	CDD:214653
IGc2	4092..4155	CDD:197706
Ig	4168..4258	CDD:299845
IG	4177..4256	CDD:214652
I-set	4260..4345	CDD:254352
IGc2	4274..4335	CDD:197706
IG_like	4356..4435	CDD:214653
IGc2	4364..4426	CDD:197706
I-set	4440..4526	CDD:254352
Ig	4440..4521	CDD:299845
TSP1	4533..4584	CDD:214559
TSP1	4589..4641	CDD:214559
TSP1	4646..4698	CDD:214559
TSP1	4703..4755	CDD:214559
TSP1	4760..4812	CDD:214559
TSP1	4817..4869	CDD:214559
G2F	4868..5092	CDD:214774
EGF_CA	5107..5146	CDD:214542
EGF_CA	5147..5190	CDD:284955
EGF_CA	5192..5229	CDD:214542
EGF_CA	5230..5263	CDD:238011
EGF_CA	5272..5313	CDD:284955
EGF_CA	5315..5354	CDD:214542
EGF_CA	5432..5471	CDD:214542
EGF_CA	5472..5508	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910