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Protein Alignment Dscam3 and CNTN6

DIOPT Version :10

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_055276.1	Gene:	CNTN6 / 27255	HGNCID:	2176	Length:	1028	Species:	Homo sapiens

Alignment Length:	1074	Identity:	248/1074 - (23%)
Similarity:	399/1074 - (37%)	Gaps:	226/1074 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 NCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGR-RDRGVYQCLVENQRA 424
            ||...|.......|..||..:....:.....|.      .||.:.:... :|.|:||||..|
Human    49 NCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDG------GSLAINSPHTDQDIGMYQCLATN--- 104

  Fly   425 SAQAMAELKLGDTV---PELIYTFIEQ---------NVRPGPLISLKCSASGSPPPQF-----AW 472
                    .||..:   .:|.:.:||.         :||.|..:.|.|    .|||.|     ||
Human   105 --------LLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLC----GPPPHFGDLSYAW 157

  Fly   473 LLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVY 537
            ..:..|:.....:.||.        .....:|.|:.|.|.|.|.|.|..:|.      .|:.:|.
Human   158 TFNDNPLYVQEDNRRFV--------SQETGNLYIAKVEPSDVGNYTCFITNK------EAQRSVQ 208

  Fly   538 GPP------------------YVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNH 584
            |||                  .||....|:|.....:.:.|...|.||..|.|.:
Human   209 GPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRR---------- 263

  Fly   585 YELASVADGGQLVIKNVEPGR------------------DQGIYTCIVRSRAGEEARRDMQLNVN 631
                  .||..|      ||:                  |:|.|.||..:..|....:. ||...
Human   264 ------LDGSPL------PGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKG-QLIFY 315

  Fly   632 SPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSI--PSSLQITEKKEEFYSLLVF 694
            :||..|......:|.........|..|....| :::|.|:...:  ...:||..      ..|:.
Human   316 APPEWEQKIQNTHLSIYDNLLWECKASGKPNP-WYTWLKNGERLNPEERIQIEN------GTLII 373

  Fly   695 KDISARHSGKYTCYASNAAAKVNYTAELQVRV-APRWRYEPM--DTAIMLGNTISINCEAEGYPI 756
            ..::...||.|.|.|.|....:...|||:|.. ||.:...|:  .:.:.:|..|.|.|:...:|.
Human   374 TMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPR 438

  Fly   757 PTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNE---- 817
            ..|:|.:|.....:..:...:.:.||.:...|.:|.|.|.|.|||:.|.. |.|..:.|.|
Human   439 AAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTA-KNTGSLIVKERTVI 502

  Fly   818 ---PARFEQSARNISSRRNDPVTLDCHAKGDEPITI--GWTQNNGRIDLNNFRFSIAEMKTEKGV 877
               |::.:.:.       .:.:.|.|....|..|.:  .|..|...|||..   .:|..:...|.
Human   503 TVPPSKMDVTV-------GESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKK---GVAHFERIGGE 557

  Fly   878 D-SQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPF 941
            . ..|.|.:...|.||.|.|..:........:..:.|:..|..|..:::.::.|.|.:||||...
Human   558 SVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGP 622

  Fly   942 DGNSPVLSYLVQ--------YQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRES 998
            |.|||:..:.:|        :||:                      .::|.....::|      :
Human   623 DNNSPIQIFTIQTRTPFSVGWQAV----------------------ATVPEILNGKTY------N 659

  Fly   999 AIVAGLTPATTFLIRMQAINEI---ERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQ 1060
            |.|.||:|...:..|:.|.|.|   |.|..:|  :|:|:...|..||.|:....|..|||::||:
Human   660 ATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSE--LLRTKASVPVVAPVNIHGGGGSRSELVITWE 722

  Fly  1061 IPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLR--GLRKYSRYAVTI 1123
            ..|.|..|||..||.         |.|..|.:::.....||...:::...|  .:...|.:.|.:
Human   723 SIPEELQNGEGFGYI---------IMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKV 778

  Fly  1124 RAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILY- 1187
            ...|:.|.|..|......:.|..|:.||:..:..:.|:..:::||.......:.|.:.||::||
Human   779 GVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYW 843

  Fly  1188 -----RPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDD 1247
                 ..::.:|.....:..|..:.|:.  :|::.||     |.||...|.|.:|.|:...|...
Human   844 TDDSKESMIGKIRVSGNVTTKNITGLKA--NTIYFAS-----VRAYNTAGTGPSSPPVNVTTKKS 901

  Fly  1248 VPDAPAAIKAAALTADSILISW---LTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYP- 1308
            .|..|.|..|..||...:.::|   .|.:|.:.::.:..:|.:..    |:|||::..:.....
Human   902 PPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNR----QSKTHILETNNTSAEL 962

  Fly  1309 -VTFESRSLAENQMYEFWVSASTSVGEGEPTSVI 1341
             |.||...|.|       :...:..|:|..:..|
Human   963 LVPFEEDYLIE-------IRTVSDGGDGSSSEEI 989

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.