DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and CNTN6

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001276009.1	Gene:	CNTN6 / 27255	HGNCID:	2176	Length:	1028	Species:	Homo sapiens

Alignment Length:	1074	Identity:	248/1074 - (23%)
Similarity:	399/1074 - (37%)	Gaps:	226/1074 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 NCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGR-RDRGVYQCLVENQRA 424
            ||...|.......|..||..:....:.....|.      .||.:.:... :|.|:||||..|
Human    49 NCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDG------GSLAINSPHTDQDIGMYQCLATN--- 104

  Fly   425 SAQAMAELKLGDTV---PELIYTFIEQ---------NVRPGPLISLKCSASGSPPPQF-----AW 472
                    .||..:   .:|.:.:||.         :||.|..:.|.|    .|||.|     ||
Human   105 --------LLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLC----GPPPHFGDLSYAW 157

  Fly   473 LLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVY 537
            ..:..|:.....:.||.        .....:|.|:.|.|.|.|.|.|..:|.      .|:.:|.
Human   158 TFNDNPLYVQEDNRRFV--------SQETGNLYIAKVEPSDVGNYTCFITNK------EAQRSVQ 208

  Fly   538 GPP------------------YVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNH 584
            |||                  .||....|:|.....:.:.|...|.||..|.|.:
Human   209 GPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRR---------- 263

  Fly   585 YELASVADGGQLVIKNVEPGR------------------DQGIYTCIVRSRAGEEARRDMQLNVN 631
                  .||..|      ||:                  |:|.|.||..:..|....:. ||...
Human   264 ------LDGSPL------PGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKG-QLIFY 315

  Fly   632 SPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSI--PSSLQITEKKEEFYSLLVF 694
            :||..|......:|.........|..|....| :::|.|:...:  ...:||..      ..|:.
Human   316 APPEWEQKIQNTHLSIYDNLLWECKASGKPNP-WYTWLKNGERLNPEERIQIEN------GTLII 373

  Fly   695 KDISARHSGKYTCYASNAAAKVNYTAELQVRV-APRWRYEPM--DTAIMLGNTISINCEAEGYPI 756
            ..::...||.|.|.|.|....:...|||:|.. ||.:...|:  .:.:.:|..|.|.|:...:|.
Human   374 TMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPR 438

  Fly   757 PTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNE---- 817
            ..|:|.:|.....:..:...:.:.||.:...|.:|.|.|.|.|||:.|.. |.|..:.|.|
Human   439 AAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTA-KNTGSLIVKERTVI 502

  Fly   818 ---PARFEQSARNISSRRNDPVTLDCHAKGDEPITI--GWTQNNGRIDLNNFRFSIAEMKTEKGV 877
               |::.:.:.       .:.:.|.|....|..|.:  .|..|...|||..   .:|..:...|.
Human   503 TVPPSKMDVTV-------GESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKK---GVAHFERIGGE 557

  Fly   878 D-SQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPF 941
            . ..|.|.:...|.||.|.|..:........:..:.|:..|..|..:::.::.|.|.:||||...
Human   558 SVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGP 622

  Fly   942 DGNSPVLSYLVQ--------YQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRES 998
            |.|||:..:.:|        :||:                      .::|.....::|      :
Human   623 DNNSPIQIFTIQTRTPFSVGWQAV----------------------ATVPEILNGKTY------N 659

  Fly   999 AIVAGLTPATTFLIRMQAINEI---ERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQ 1060
            |.|.||:|...:..|:.|.|.|   |.|..:|  :|:|:...|..||.|:....|..|||::||:
Human   660 ATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSE--LLRTKASVPVVAPVNIHGGGGSRSELVITWE 722

  Fly  1061 IPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLR--GLRKYSRYAVTI 1123
            ..|.|..|||..||.         |.|..|.:::.....||...:::...|  .:...|.:.|.:
Human   723 SIPEELQNGEGFGYI---------IMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKV 778

  Fly  1124 RAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILY- 1187
            ...|:.|.|..|......:.|..|:.||:..:..:.|:..:::||.......:.|.:.||::||
Human   779 GVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYW 843

  Fly  1188 -----RPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDD 1247
                 ..::.:|.....:..|..:.|:.  :|::.||     |.||...|.|.:|.|:...|...
Human   844 TDDSKESMIGKIRVSGNVTTKNITGLKA--NTIYFAS-----VRAYNTAGTGPSSPPVNVTTKKS 901

  Fly  1248 VPDAPAAIKAAALTADSILISW---LTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYP- 1308
            .|..|.|..|..||...:.::|   .|.:|.:.::.:..:|.:..    |:|||::..:.....
Human   902 PPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNR----QSKTHILETNNTSAEL 962

  Fly  1309 -VTFESRSLAENQMYEFWVSASTSVGEGEPTSVI 1341
             |.||...|.|       :...:..|:|..:..|
Human   963 LVPFEEDYLIE-------IRTVSDGGDGSSSEEI 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	16/72 (22%)
		Ig	358..431	CDD:143165	16/70 (23%)
		Ig	456..533	CDD:143165	20/81 (25%)
		IGc2	553..619	CDD:197706	16/83 (19%)
		I-set	634..724	CDD:254352	20/91 (22%)
		ig	645..712	CDD:278476	14/68 (21%)
		IG_like	734..815	CDD:214653	22/82 (27%)
		Ig	745..815	CDD:299845	20/69 (29%)
		I-set	820..913	CDD:254352	18/95 (19%)
		Ig	838..920	CDD:299845	20/84 (24%)
		FN3	917..1033	CDD:238020	30/126 (24%)
		FN3	1040..1142	CDD:238020	28/103 (27%)
		fn3	1150..1237	CDD:278470	21/92 (23%)
		FN3	1263..1345	CDD:238020	16/84 (19%)
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
CNTN6	NP_001276009.1	Ig	26..118	CDD:325142	19/85 (22%)
		Ig	120..214	CDD:325142	30/111 (27%)
		Ig	227..315	CDD:325142	23/110 (21%)
		Ig	319..403	CDD:325142	19/90 (21%)
		Ig	424..496	CDD:325142	21/72 (29%)
		Ig	515..598	CDD:325142	19/85 (22%)
		FN3	598..691	CDD:238020	28/120 (23%)
		FN3	703..796	CDD:238020	28/101 (28%)
		FN3	805..898	CDD:238020	23/99 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..908		6/20 (30%)
		FN3	906..991	CDD:238020	21/95 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910