DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and SIGLEC7

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_055200.1 Gene:SIGLEC7 / 27036 HGNCID:10876 Length:467 Species:Homo sapiens


Alignment Length:523 Identity:98/523 - (18%)
Similarity:167/523 - (31%) Gaps:185/523 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 RQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFT----------WY 281
            |:|.:......|:.|..:....|        |:.|..||:.|:..   :|:.:          |:
Human    13 RERVEGQKSNRKDYSLTMQSSVT--------VQEGMCVHVRCSFS---YPVDSQTDSDPVHGYWF 66

  Fly   282 RV-SDSAALYPI----------------------PSSQRVILSRTLLLIKNADERDAGKWICQAS 323
            |. :|.:...|:                      |.::...||     |::|...|||::.    
Human    67 RAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQTKNCTLS-----IRDARMSDAGRYF---- 122

  Fly   324 NQFGEQRIEIR-------LSVNSYVSVHILPQVQI---VNSGGTANFNCTTTGSAIDA----IDW 374
              |..::..|:       ||||.....| .|.:.|   :.||...|..|:...:....    |.|
Human   123 --FRMEKGNIKWNYKYDQLSVNVTALTH-RPNILIPGTLESGCFQNLTCSVPWACEQGTPPMISW 184

  Fly   375 LHNG-KPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGV-YQCLVENQRASAQAMAELKLGDT 437
            :... .||..:.            ::||:|......:..|. ..|.|....|.......::|..:
Human   185 MGTSVSPLHPST------------TRSSVLTLIPQPQHHGTSLTCQVTLPGAGVTTNRTIQLNVS 237

  Fly   438 VP--ELIYTFIE--------------QNVRPGPLISLKCSASGSPPPQFAW------LLDSQP-- 478
            .|  .|..|..:              .:|..|..:.|.|:...:||.:.:|      |..|||  
Human   238 YPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVCAVDSNPPARLSWTWRSLTLYPSQPSN 302

  Fly   479 --IMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPY 541
              ::::.:|    :|                     |.|.:.|.|.||:||...|..|::. ..|
Human   303 PLVLELQVH----LG---------------------DEGEFTCRAQNSLGSQHVSLNLSLQ-QEY 341

  Fly   542 VRAIGPIKAV-------AGEDIIVHCPF-------------AGYP-----------VEQIRWEKA 575
            ...:.|:..|       ||...:|...|             :..|           ...||...:
Human   342 TGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGDIGMKDANTIRGSAS 406

  Fly   576 HQELTTS------NHYELASVADGGQLVIK----NVEPGRDQGIYTCIVRSRAGEEARRDMQLNV 630
            ...||.|      .|:.||:.:.|.:..|:    :...|..|.:        :|:||..:....:
Human   407 QGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDL--------SGQEATNNEYSEI 463

  Fly   631 NSP 633
            ..|
Human   464 KIP 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352 22/130 (17%)
Ig 264..334 CDD:143165 17/102 (17%)
I-set 345..433 CDD:254352 17/96 (18%)
Ig 358..431 CDD:143165 13/78 (17%)
Ig 456..533 CDD:143165 20/86 (23%)
IGc2 553..619 CDD:197706 16/99 (16%)
I-set 634..724 CDD:254352 98/523 (19%)
ig 645..712 CDD:278476
IG_like 734..815 CDD:214653
Ig 745..815 CDD:299845
I-set 820..913 CDD:254352
Ig 838..920 CDD:299845
FN3 917..1033 CDD:238020
FN3 1040..1142 CDD:238020
fn3 1150..1237 CDD:278470
FN3 1263..1345 CDD:238020
Ig 1350..1436 CDD:299845
IG_like 1358..1436 CDD:214653
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
SIGLEC7NP_055200.1 Ig_Siglec_N 26..144 CDD:143189 26/139 (19%)
Sialic acid binding. /evidence=ECO:0000269|PubMed:12438315, ECO:0000269|PubMed:16623661, ECO:0000269|PubMed:16895906 131..135 0/3 (0%)
Ig 150..223 CDD:325142 16/84 (19%)
IG_like 261..336 CDD:214653 22/99 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 401..431 8/29 (28%)
ITIM motif 435..440 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 443..467 6/32 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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