DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and ttn-1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001346715.1	Gene:	ttn-1 / 266969	WormBaseID:	WBGene00006436	Length:	15188	Species:	Caenorhabditis elegans

Alignment Length:	2093	Identity:	427/2093 - (20%)
Similarity:	736/2093 - (35%)	Gaps:	605/2093 - (28%)

- Green bases have known domain annotations that are detailed below.

Fly 34 GLRVPTFLLE-PAPRLLFGNDTGAQVT--CTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTL 95
|.:.|.|.:: |.||.: ..||.:| |:..|:|.|.:.|...|..:......:|..:|..||
Worm 13227 GSKAPRFRMQLPTPREV---PQGADLTLVCSVSGTPHPNIKWTKDDKPIDMSNKQVRHENGVCTL 13288

Fly 96 HFPPFLAQYYRTDVHEATYRCRASNEAGTVLSRNV--------QVHAVVRRQFHVHVENTEVYLG 152
|. ....|..:..|.|.|.|..|...|.:| :.| ||.:|...:.|.....|
Worm 13289 HI------IGARDDDQGRYVCEAENIHGVAQSFSVVEIKEAVDKDH--VRPKFLEPLVNCSTCEG 13345

Fly 153 NSALIKCAIPEYVRPYVRVASWHR-GEEILLPD----LSDVAG------RYVVLAASGDLYVRSV 206
|..:::|.:.....|.: :|:: |.::::.: .:|..| ..||:...|:....:|
Worm 13346 NEMVLECCVTGKPIPTI---TWYKDGLKLIIENRMLQYTDRKGVSRLNIMNVVMNDDGEYTCEAV 13407

Fly 207 RS-------------EDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQKPVMEIHV 258
.| :.||.|.......:.:..|.||.:|: ..|:.: |....:|:.:..|
Worm 13408 NSLGKDFTHCTVKVVDMGLSKTRLTPVRSRSRSRSRSPSVV--GGEIQR---PPVVTRPLADATV 13467

Fly 259 ERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTL----------LLIKNADER 313
..||...|...:.|.|.|...||. ..:.|..|||| |.|..|.|.
Worm 13468 TEGNRELLEVEVDGFPTPTIEWYH-----------DGKLVAESRTLRTYFDGRVAFLKIYEAHEE 13521

Fly 314 DAGKWICQASNQFGEQRIEIRLSV-------NSYVS-----VHILPQVQIVNSGGTANFNCTTTG 366
..|:::|:.||:.| .:|.|..| ..:|: |..|..|.:..:|.||.|.|.:..
Worm 13522 HNGQYVCKVSNKLG--AVETRAIVVVEAPDAAEHVTQMPTFVKKLQDVVLKTAGETATFTCQSYA 13584

Fly 367 SAIDAIDWLHNGKPLQANNALTTGR---DNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQA 428
:....:.||||||.||...:....| || .::|:::||.....|.|..:..||......
Worm 13585 NPAAQVVWLHNGKALQQTKSNYKTRLFDDN-----TATLVIENVTDELCGTYTAVANNQFGDVHT 13644

Fly 429 MAEL--------KLGDTVPELIYTFIEQ----NVRPGPLISLKCSASGSPPPQFAWLLDSQPIMD 481
.|:| |:..::| |..||. ||..|..:|::...:|||.|:..||.|:..:::
Worm 13645 SAQLTISGSEAKKIAASLP---YFIIELKPKINVVEGATLSIQADLNGSPIPEVVWLKDNSELVE 13706

Fly 482 VSLHHRFAIGQFVDMSGDVISH-LNISHVRPDDGGLYKCVASNSMGSVQHSARLNV--------- 536
...:.|..|.::: |.:..|..:|.|.|...|.|..|.::.:..::|
Worm 13707 ---------SDRIQMKCDGVNYQLLVRDVGLEDEGTYTITAENEKGKIRQNTEVSVTKSKEVKEK 13762

Fly 537 -----------------------------------------YGP--------------------- 539
.||
Worm 13763 KEKKKVEKKDEGKKKPGRPGLPRPSGASKTEQVTMAFDAPSEGPADSYEVERRCPDQREWVSCGS 13827

Fly 540 ---------------PYV-RAIGPIKAVAGE---------------------------------D 555
.|: |..|..|...|| :
Worm 13828 TKSLELEIKGLTPNTEYIFRVAGKNKQGLGEWSEMTSTLKTASVGQAPQFTISPQSKIIANRDDE 13892

Fly 556 IIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGE 620
..:...|:|.|...::|.|.:.::......::|:.:....|.:|:.| :.|.:.|::.:..|:
Worm 13893 FEIAVEFSGTPTPSVKWYKENLQIVPDEKIDVATTSTSSILNLKSQE---ENGTFNCLIENELGQ 13954

Fly 621 ----------------EARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWK 669
::..|..|..|..|.::.....::.|.|.:..:||.:||..... .:|.
Worm 13955 ASASCQVTIFNKPASLQSTPDHSLERNLVPTLQKALNNESAQAGQQIMLTCRISSRSEST-VAWF 14018

Fly 670 KDDSSIPSS--LQITEKKEEFYSLLVFKDISARHSGKYTCYASN----AAAKVNYTAELQVR-VA 727
|||..|.|: .:::..|:..:. ||...:.::.:|||.|..:| |.::.|...|...: :|
Worm 14019 KDDERIESAGRYELSSDKKSNHK-LVCHAVQSQDTGKYRCVVTNKYGYAESECNVAVEDVTKFIA 14082

Fly 728 PRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMR-----------NHS 781
|.:.....|:..:||:.|::.|:.||.|.|.::| :||.:.:|.. |..
Worm 14083 PSFSATLSDSTAILGHNITLECKVEGSPAPEVSW-------TKDGERISTTRRIRQTQDENGNCK 14140

Fly 782 LLLNLATDNDEGYYMCQATNEIGAG-------LKKTIRIN-----------VNEPARFEQSARN- 827
|.::.|..:|.|.|:|.||:..|.. :.||...: .:|..||.::..:
Worm 14141 LSISKAESDDMGVYVCSATSVAGVDSTSSMVMIAKTTGTDSHLVIAQTADEKHEKPRFTRAPPSL 14205

Fly 828 ISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRH--- 889
|....:...||...|.|:...|:.|.::...| ::|.: :......|..:.|
Worm 14206 IEVNESGQFTLIAKAVGEPKPTVTWLKDGREI-----------LRTNR-IYHHFVTGDGESHLIA 14258

Fly 890 ------DSGVYRCIAENPYGR--AE-QIIFLAVQERPDTPSHLEIFEVGSR-TVKLSWRRPFDGN 944
.||::.|.||||.|. || |:|...:: |:: ::..|..: |:.|:.....:|:
Worm 14259 ECVVSKTSGIFSCKAENPNGTVIAETQVIVQRMK-----PAN-QLANVAPKFTIPLTDMGIVNGH 14317

Fly 945 SPVLSYLV---QYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTP 1006
...||..| ....|:::.. |.:||.||::..:|..:......:.|
Worm 14318 PTTLSCNVTGSPEPTLEWIYI---------DDSGHKINLTSSTTDWTECRFGKVAE--------- 14364

Fly 1007 ATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEA---PSNVQVQTGGESELIV----TWQIPPR 1064
::.:.:...:|..| :.|...:..:|.|:. ...:..:..|....:. || .|.:
Worm 14365 -----LKSERVLREQRGTY-QCIATNSSGQATTQCYLLVGELSDEPAGPPRFVKCLQDTW-TPLK 14422

Fly 1065 ES--WNGELIGY---TVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIR 1124
|| ::.||.|: .:.....::.||....|..:..|...|..:....:|..|..| .:.
Worm 14423 ESIEFSVELAGFPTPDLTWYHNEKKINEGKDVKITFPSDTTSVLSIKNVSLASLGMY-----FVE 14482

Fly 1125 AMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRP 1189
|.|..| :..| |...|| |.:..| .||| || |.:..|
Worm 14483 ASNIHG-------VLRT-------AGRLNV-----SDERRK---AEPP-QF--------KHVLEP 14516

Fly 1190 IVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAA 1254
:: .::.|...:.| |....:|..:.||....| |:|.|..:|:.
Worm 14517 VL-------AVQPKVAFSEE---HPRASSSAATARVKKGAA--------PMFLQGLEDMD----- 14558

Fly 1255 IKAAALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAEN 1319
:||.|..| :..|....:..|.:. :.:|.:..:|....:|:||....:.....|.|..
Worm 14559 LKAGASAA-------VAGKLGRKLRPHRST-TNDADKLAKALAQSLRLDEPRASIDSRPESAANA 14615

Fly 1320 QMYEFWVSASTS---------VGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAV 1375
.:.|...:.::. :.:.:|..|:.:..:.|....|:
Worm 14616 ALDEVRAAINSRNKRVCRPKFMVKPKPRKVLEEYKSLRLKTAIS--------------------- 14659

Fly 1376 GNPTPRARWLTRDRPVTFSPFYEVTNEGN---LKIHRVEGSLSGNYTCTANNLFG----SDEIQY 1433
|||.|:..|......:.....|.:.|:|: |::|.|.....|.|.|||.|..| :.||
Worm 14660 GNPMPQVHWDKEGIILETGNKYSIYNDGDFYYLEVHHVSTFDKGFYNCTAANNEGIITCTSEI-- 14722

Fly 1434 QVIAMKPPSAPQIIVQYASADS-----IRVSWDAPDDGGAPL------QGYTISYHTAGESW--S 1485
.|:..|..||.|:..:.:..:: |.| .|....|.| :....:|..|...| :
Worm 14723 DVLPNKEDSAAQVAKRKSRKEAKAPNFIEV---LPGRSQANLNESLCVECSVSAYPCASIIWTRN 14784

Fly 1486 ITELLPENNAFTIS------GLKC-----GNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPN 1539
...|||:.:.:|:| .||. |::......|.|.:||.|.:..:.| :...||
Worm 14785 SVRLLPQADRYTMSYDGECASLKFISVTPGDEGTYACEAVNELGSAVTNMNLQV-----SGVDPN 14844

Fly 1540 ANELI--------------ATNATCVNLKLSSWQNGGCSIHHFSIEHRPLGDIRW-----TVVTS 1585
|.|.| ..:.:.|.|.....| ...|| .||| |:|.|
Worm 14845 AAEGIPPLFRFEKIKSVRKVVDGSRVELAAELVQ-----------ASEPL-QIRWLRNKVTIVDS 14897

Fly 1586 DISNAEENRENLIF---CDFLPAKWYQLRISATNDAG----------KTTEH---------YHFS 1628
. |.:....||::| .|..|....:..:.|.|.:| :..|. :.|.
Worm 14898 P-SFSYSRSENMVFLTIADVFPEDGGEYTVEAKNQSGIARCTMQLDVRNNERSVADEAPRVFDFE 14961

Fly 1629 -TTNID-GITI---------PPPSV-FPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITI 1681
||..| |::: |.|.: :......:||.........||.| |:.::.:|.
Worm 14962 PTTRSDPGVSVELRAKVIGHPDPVISWTKAGQKLNNEEKYMMRNEGDKF-------ILRIANVTR 15019

Fly 1682 ALTIKHRRTLCGPIAEGYESRTLPGDYKEDHENRRNQQVYSASP--VKTVDKGNESEMYEISPYA 1744
|...|:..|...| .|..:..|.....:..:....:..::.|| |:|.:| |.:|: .|
Worm 15020 ADAGKYELTAINP--SGQANAELELTVVQSTKTVGAKPKFNESPISVQTCEK-NRAEL-----RA 15076

Fly 1745 TFSVNGGRTGAPA 1757
:|| |.||
Worm 15077 SFS------GTPA 15083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	21/86 (24%)
		Ig	56..125	CDD:143165	19/70 (27%)
		I-set	246..337	CDD:254352	27/100 (27%)
		Ig	264..334	CDD:143165	21/79 (27%)
		I-set	345..433	CDD:254352	27/98 (28%)
		Ig	358..431	CDD:143165	21/75 (28%)
		Ig	456..533	CDD:143165	18/77 (23%)
		IGc2	553..619	CDD:197706	13/98 (13%)
		I-set	634..724	CDD:254352	24/95 (25%)
		ig	645..712	CDD:278476	20/72 (28%)
		IG_like	734..815	CDD:214653	25/109 (23%)
		Ig	745..815	CDD:299845	22/98 (22%)
		I-set	820..913	CDD:254352	25/105 (24%)
		Ig	838..920	CDD:299845	21/93 (23%)
		FN3	917..1033	CDD:238020	19/119 (16%)
		FN3	1040..1142	CDD:238020	20/113 (18%)
		fn3	1150..1237	CDD:278470	18/86 (21%)
		FN3	1263..1345	CDD:238020	12/90 (13%)
		Ig	1350..1436	CDD:299845	21/92 (23%)
		IG_like	1358..1436	CDD:214653	20/84 (24%)
		FN3	1441..1530	CDD:238020	25/112 (22%)
		FN3	1542..1620	CDD:238020	22/109 (20%)
ttn-1	NP_001346715.1	IG	105..177	CDD:214652
		I-set	205..285	CDD:333254
		I-set	406..493	CDD:333254
		I-set	821..914	CDD:333254
		Ig	962..1032	CDD:319273
		I-set	1135..1215	CDD:333254
		I-set	1679..1767	CDD:254352
		Ig	1789..>1845	CDD:319273
		Atrophin-1	<1957..2285	CDD:331285
		I-set	2381..2468	CDD:333254
		I-set	2489..2578	CDD:333254
		I-set	2631..2717	CDD:333254
		I-set	2732..2815	CDD:333254
		Ig	2848..2909	CDD:319273
		I-set	2924..3007	CDD:333254
		RNase_E_G	<3161..3303	CDD:331378
		RNase_E_G	<3356..3556	CDD:331378
		RNase_E_G	<3506..3673	CDD:331378
		RNase_E_G	<3595..3803	CDD:331378
		RNase_E_G	<3722..3912	CDD:331378
		RNase_E_G	<3875..4073	CDD:331378
		FtsK	<4014..>4556	CDD:332908
		RNase_E_G	<4346..4567	CDD:331378
		RNase_E_G	<4525..4723	CDD:331378
		RNase_E_G	<4746..4936	CDD:331378
		RNase_E_G	<4858..5044	CDD:331378
		FtsK	<4960..>5541	CDD:332908
		Neuromodulin_N	<5525..6250	CDD:331332
		Neuromodulin_N	<6198..6681	CDD:331332
		V-ATPase_G_2	<6559..>6683	CDD:330366
		I-set	7448..7535	CDD:333254
		FN3	7540..7630	CDD:238020
		MDN1	<7687..8197	CDD:331582
		Neuromodulin_N	<7944..8780	CDD:331332
		Ig	8886..>8935	CDD:325142
		FN3	9052..9142	CDD:238020
		Neuromodulin_N	<9210..9875	CDD:331332
		Neuromodulin_N	<9583..10392	CDD:331332
		IG_like	10597..>10662	CDD:214653
		Ig	10711..10773	CDD:325142
		FN3	10777..10870	CDD:238020
		FN3	10883..10958	CDD:238020
		FN3	10984..11070	CDD:238020
		I-set	11077..11165	CDD:333254
		IG	11179..11259	CDD:214652
		I-set	11264..11350	CDD:333254
		I-set	11368..11446	CDD:333254
		FN3	11450..11543	CDD:238020
		FN3	11565..11645	CDD:238020
		I-set	11823..11903	CDD:333254
		I-set	11918..11996	CDD:333254
		FN3	12006..12097	CDD:238020
		FN3	12131..12217	CDD:238020
		I-set	12225..12313	CDD:333254
		Ig	12337..12411	CDD:325142
		FN3	12415..12503	CDD:238020
		PKc_like	12566..12815	CDD:328722
		I-set	12894..12985	CDD:254352
		I-set	13024..13114	CDD:333254
		I-set	13123..13206	CDD:254352
		Ig	13249..13314	CDD:319273	18/70 (26%)
		I-set	13331..13421	CDD:254352	15/92 (16%)
		I-set	13456..13545	CDD:254352	27/101 (27%)
		I-set	13558..13650	CDD:254352	28/96 (29%)
I-set	13663..13753	CDD:254352	25/101 (25%)
FN3	13778..13864	CDD:238020	8/85 (9%)
Ig	13893..13963	CDD:325142	12/72 (17%)
I-set	13984..14074	CDD:333254	23/91 (25%)
I-set	14083..14168	CDD:254352	24/91 (26%)
Ig_3	14195..14275	CDD:316449	17/91 (19%)
Ig_3	14302..14384	CDD:316449	17/105 (16%)
I-set	14408..14498	CDD:333254	21/109 (19%)
I-set	14634..14724	CDD:333254	24/112 (21%)
IG_like	14754..14838	CDD:214653	19/83 (23%)
I-set	14854..14943	CDD:333254	20/101 (20%)
I-set	14969..15044	CDD:254352	16/83 (19%)
Ig_3	15054..15132	CDD:316449	13/42 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910