DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and MDGA1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_006715119.1	Gene:	MDGA1 / 266727	HGNCID:	19267	Length:	973	Species:	Homo sapiens

Alignment Length:	785	Identity:	182/785 - (23%)
Similarity:	290/785 - (36%)	Gaps:	182/785 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 HILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKS----SLLV 404
            :|..:|..:..|.|....|..||.....:.|           ..|.|..:.:|...|    :|.:
Human    42 NISERVYTIREGDTLMLQCLVTGHPRPQVRW-----------TKTAGSASDKFQETSVFNETLRI 95

  Fly   405 QNVGRRDRGVYQCLVENQ---------RASAQAMAE--LKLGDTVPELIYTFIEQNVRPGPLISL 458
            :.:.|...|.|.|..||.         |...|.:.|  |.:..||.::...|.::..     :.|
Human    96 ERIARTQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKT-----VFL 155

  Fly   459 KCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISH-----LNISHVRPDDGGLYK 518
            :|:.:.:||.:|.|...|.     :|.|....|  ||:...:.:.     |.:.::||.|...|.
Human   156 RCTVNSNPPARFIWKRGSD-----TLSHSQDNG--VDIYEPLYTQGETKVLKLKNLRPQDYASYT 213

  Fly   519 C-VASNSMGSVQHSA---RL-NVYGPPYVR-------AIGPIKAVAGEDIIVHCPF-AGYPVEQI 570
            | |:..::..:...|   || |...||.::       .:.|     ||::.|.|.. .|.|:.|:
Human   214 CQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNP-----GENVTVQCLLTGGDPLPQL 273

  Fly   571 RWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNS--- 632
            :|......|      .|.::|.||.|.|.:|: .||.|.|.|...:..|..|::.:.|.|.|
Human   274 QWSHGPGPL------PLGALAQGGTLSIPSVQ-ARDSGYYNCTATNNVGNPAKKTVNLLVRSMKN 331

  Fly   633 ------PPVIEPFKFPKNLQEGGRAQITCAVSSGDMP---IYFSWKKD--DSSIPSSLQITEKKE 686
                  |.||   |..:|:|.|...:::|.|.:  :|   :.:.|.|:  .:.:...|.:|....
Human   332 ATFQITPDVI---KESENIQLGQDLKLSCHVDA--VPQEKVTYQWFKNGKPARMSKRLLVTRNDP 391

  Fly   687 EF---YSLLVFKDISARHSGKYTCYAS-------NAAAKVNYTAELQVRVAPRWRYEPMDTAIML 741
            |.   .|.|...|:.....|.|.|.||       :.:.:||.::|    ..|.....|...|::.
Human   392 ELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSE----TVPPTISVPKGRAVVT 452

  Fly   742 ---GNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDND----------EG 793
               |:...:.||..|.|.|.:.|       |:..|..::....|.|....|..          .|
Human   453 VREGSPAELQCEVRGKPRPPVLW-------SRVDKEAALLPSGLPLEETPDGKLRLERVSRDMSG 510

  Fly   794 YYMCQATNEIGAGLK---KTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQN 855
            .|.||.....|..::   ..:::||..|...|.|::::......||.|.|......|
Human   511 TYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGSP-------- 567

  Fly   856 NGRIDLNNFRFS--------IAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLA 912
             .||....:||.        :.....|....::|.:....|..||.|.|...|..|.|..:..::
Human   568 -QRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSAACLFQVS 631

  Fly   913 VQERP-----DTPSHLEIFEVGSRTVKLS--------W--RRPFDGNSPVLSYLVQYQALKYLQS 962
            .:...     |||:       .:|:.|||        |  |.| |...|||:|.:   :::.|..
Human   632 AKAYSPEFYFDTPN-------PTRSHKLSKNYSYVLQWTQREP-DAVDPVLNYRL---SIRQLNQ 685

  Fly   963 HGSLAAA---GGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSA 1024
            |.::..|   .....|.::...|....:..||:         ..|||.|||.....|...|.
Human   686 HNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYE---------VRLTPYTTFGAGDMASRIIH--- 738

  Fly  1025 YTEAI 1029
            |||.|
Human   739 YTEPI 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	22/102 (22%)
		Ig	358..431	CDD:143165	17/85 (20%)
		Ig	456..533	CDD:143165	20/85 (24%)
		IGc2	553..619	CDD:197706	21/66 (32%)
		I-set	634..724	CDD:254352	25/104 (24%)
		ig	645..712	CDD:278476	18/81 (22%)
		IG_like	734..815	CDD:214653	19/96 (20%)
		Ig	745..815	CDD:299845	16/82 (20%)
		I-set	820..913	CDD:254352	21/100 (21%)
		Ig	838..920	CDD:299845	18/94 (19%)
		FN3	917..1033	CDD:238020	34/131 (26%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
MDGA1	XP_006715119.1	IG_like	46..126	CDD:214653	19/90 (21%)
		IGc2	52..115	CDD:197706	17/73 (23%)
		IG_like	152..217	CDD:214653	18/76 (24%)
		Ig	153..217	CDD:143165	18/70 (26%)
		IG_like	248..326	CDD:214653	25/89 (28%)
		IGc2	254..315	CDD:197706	22/72 (31%)
		IGc2	350..418	CDD:197706	15/69 (22%)
		IG_like	450..535	CDD:214653	17/91 (19%)
		IGc2	455..515	CDD:197706	14/66 (21%)
		Ig	541..622	CDD:299845	19/89 (21%)
		IG_like	543..631	CDD:214653	20/96 (21%)
		MAM	753..917	CDD:279023
		MAM	753..916	CDD:99706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910