DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam3 and LRIT1

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_056428.1 Gene:LRIT1 / 26103 HGNCID:23404 Length:623 Species:Homo sapiens


Alignment Length:468 Identity:97/468 - (20%)
Similarity:160/468 - (34%) Gaps:150/468 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1360 VRKAVGTGLVLECLAVGNPTPRARW-LTRDRPVTFSPFYEVTNEGN----LKIHRVEGSLSGNYT 1419
            :|..:|...:|.|.|.|.|.|...| ....||:..:...||:::|.    |.:..|....||:|.
Human   263 IRSLLGGTALLRCGATGVPGPEMSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYI 327

  Fly  1420 CTANNLFGSDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYT---ISYH--- 1478
            |.|.|..|:.|....:|..:||::.:      .:.|....| |...||.....|.   ::.|   
Human   328 CQAKNFLGASETVISLIVTEPPTSTE------HSGSPGALW-ARTGGGGEAAAYNNKLVARHVPQ 385

  Fly  1479 -------TAGESWSIT--ELLPENNAFTISGL------KCGNQYIIKMSAHNMVGSGVASEEINV 1528
                   ..|.|...|  ||..|:  |.:..|      :.|......:.:..:||....|..: |
Human   386 IPKPAVLATGPSVPSTKEELTLEH--FQMDALGELSDGRAGPSEARMVRSVKVVGDTYHSVSL-V 447

  Fly  1529 WTKGKASQAPNANELIATNATCVNLKLSSWQNGGCSIHHFSIEHRPLG--DIRWTVVTSDISNAE 1591
            |   ||.||.|      |.|                   ||:.:...|  .:|..:|       :
Human   448 W---KAPQAKN------TTA-------------------FSVLYAVFGQHSMRRVIV-------Q 477

  Fly  1592 ENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINS 1656
            ..:..:.....||...|...:.......:..:...|||                     |.::::
Human   478 PGKTRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFST---------------------NEVVDA 521

  Fly  1657 TNPTSGDWFATLIVVVIITVSIITIALTIKHRRTL---CGPIAEGYESRTLPGDYKEDHENRRNQ 1718
            .|...      ||.||:|:|:|: |||.:    ||   |..:                  .:|.:
Human   522 ENTQQ------LINVVVISVAIV-IALPL----TLLVCCSAL------------------QKRCR 557

  Fly  1719 QVYSA-SPVKTVDKGN-------ESEMYEISPYATFSVNGGRTGAPAKTPTRAVAAQTPLDYTMQ 1775
            :.::. |...||...|       |..:.|:|.::....:            |.::|::.:|    
Human   558 KCFNKDSTEATVTYVNLERLGYSEDGLEELSRHSVSEAD------------RLLSARSSVD---- 606

  Fly  1776 FKTFGHPEGENLN 1788
            |:.||...|..:|
Human   607 FQAFGVKGGRRIN 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352
Ig 358..431 CDD:143165
Ig 456..533 CDD:143165
IGc2 553..619 CDD:197706
I-set 634..724 CDD:254352
ig 645..712 CDD:278476
IG_like 734..815 CDD:214653
Ig 745..815 CDD:299845
I-set 820..913 CDD:254352
Ig 838..920 CDD:299845
FN3 917..1033 CDD:238020
FN3 1040..1142 CDD:238020
fn3 1150..1237 CDD:278470
FN3 1263..1345 CDD:238020
Ig 1350..1436 CDD:299845 24/80 (30%)
IG_like 1358..1436 CDD:214653 24/80 (30%)
FN3 1441..1530 CDD:238020 21/109 (19%)
FN3 1542..1620 CDD:238020 10/79 (13%)
LRIT1NP_056428.1 LRR 1 60..81
leucine-rich repeat 61..84 CDD:275378
LRR_8 63..143 CDD:290566
LRR 2 84..105
leucine-rich repeat 85..132 CDD:275378
LRR 3 108..129
LRR_8 131..202 CDD:290566
LRR_4 131..171 CDD:289563
LRR 4 132..153
leucine-rich repeat 133..156 CDD:275378
LRR 5 156..177
leucine-rich repeat 157..180 CDD:275378
leucine-rich repeat 181..205 CDD:275378
TPKR_C2 201..>240 CDD:301599
Ig 267..345 CDD:299845 23/77 (30%)
IG_like 267..345 CDD:214653 23/77 (30%)
FN3 431..498 CDD:214495 20/102 (20%)
LRR 6. /evidence=ECO:0000305 571..594 4/22 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.