DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and NEGR1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens

Alignment Length:	266	Identity:	65/266 - (24%)
Similarity:	104/266 - (39%)	Gaps:	46/266 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 LLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAI 369
            |.|:|.|..|.|.:.|....|...:.:::.|:|.....::.:.....||.|......|..||...
Human   103 LQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPE 167

  Fly   370 DAIDWLH---NGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAE 431
            .:|.|.|   :.||.          :|.::|.     :..:.|...|.|:|..||. .|...:.:
Human   168 PSISWRHISPSAKPF----------ENGQYLD-----IYGITRDQAGEYECSAEND-VSFPDVRK 216

  Fly   432 LKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDM 496
            :|:.......|.......|.||....::|..:|.|||.|.|....:.:.:         ||
Human   217 VKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFN---------GQ---- 268

  Fly   497 SGDVI------SHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGE- 554
            .|.:|      |.|.:::|..:..|.|.|||:|.:|:...|..||   ||.....|    :.|.
Human   269 QGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLN---PPSTAQYG----ITGSA 326

  Fly   555 DIIVHC 560
            |::..|
Human   327 DVLFSC 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	9/31 (29%)
		Ig	264..334	CDD:143165	8/28 (29%)
		I-set	345..433	CDD:254352	20/90 (22%)
		Ig	358..431	CDD:143165	17/75 (23%)
		Ig	456..533	CDD:143165	22/82 (27%)
		IGc2	553..619	CDD:197706	3/9 (33%)
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
NEGR1	NP_776169.2	IG	47..135	CDD:214652	9/31 (29%)
		IGc2	152..210	CDD:197706	17/73 (23%)
		Ig_3	225..301	CDD:372822	23/88 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900