DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Ceacam3

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_036834.2	Gene:	Ceacam3 / 24926	RGDID:	2333	Length:	709	Species:	Rattus norvegicus

Alignment Length:	835	Identity:	167/835 - (20%)
Similarity:	274/835 - (32%)	Gaps:	288/835 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 VMLQVKELSKNLAPRTTQKPVMEI--HVERGNDV-----HLPCNIQGNPFPIFTWYR----VSDS 286
            ::|....|:..|.|.|.|..:..:  .|..|.:|     :||.|:..     |.||:    :|..
  Rat    18 LLLTASLLTCWLLPTTAQVSIESLPPQVVEGENVLLRVDNLPENLIA-----FVWYKGLTNMSLG 77

  Fly   287 AALY----------PIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSY- 340
            .|||          |:.|.:..:.|...|.|:|..::|.|.:..:..:..||......|.::.|
  Rat    78 VALYSLTYNVTVTGPVHSGRETLYSNGSLWIQNVTQKDTGFYTLRTISNHGEIVSNTSLHLHVYF 142

  Fly   341 -------------VSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDW------------------ 374
                         :|:..:|  ..::.|.:|..........:.||.|
  Rat   143 STLTCGRAATSAQLSIESVP--TSISKGESALLLAHNLPENLRAIFWYKGAIVFKDLEVARYVIG 205

  Fly   375 LHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKL--GDT 437
            .::..|..|:|    ||:.:  .|..|||:|||.|.|.|.|               .||.  .|.
  Rat   206 TNSSVPGPAHN----GRETM--YSNGSLLLQNVTRNDAGFY---------------TLKTLSTDL 249

  Fly   438 VPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWL-LDSQPIMDVS------LHH--------- 486
            ..|:.|..::.:.         |..|.:.||..|.| ::|.|.....      |.|
  Rat   250 KTEIAYVQLQVDT---------CFMSYAGPPTSAQLTVESAPTSVAEGASVLLLAHNLPENLRAI 305

  Fly   487 ---------------RFAIGQFVDMSGDVIS-----HLN----ISHVRPDDGGLY--KCVASNSM 525
                           |:.||....:.|...|     |.|    :.:|..:|.|.|  :.::::..
  Rat   306 FWYKGAILFKDLEVARYVIGTNSSVPGPAHSGRETMHSNGSLLLQNVTRNDAGFYTLRTLSTDLK 370

  Fly   526 GSVQH-SARLNVYG-----PPYVRAIGPI--KAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTS 582
            ..|.| ..::|...     .|....|.|:  .|..||.:::........:....|.|:   :.||
  Rat   371 AKVVHVQLQVNTSSCCDPLTPAPLTIDPVPRHAAKGESVLLQVRNLPEDLRMFIWFKS---VYTS 432

  Fly   583 NHYELA-------------------SVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQL 628
            ..:::|                   :|...|.|::::... :|.|:||..:..|..:.....:|:
  Rat   433 QIFKIAEYSRAINYVFRGPAHSGRETVYTNGSLLLQDATE-KDTGLYTLQIIYRNFKIETAHVQV 496

  Fly   629 NVNS---PP-----VIEPFKFPKNLQEGGRAQITCAVSSGDMP---IYFSWKKDDSSIPSSLQIT 682
            :|::   |.     |||  ..|.|:.|||...:..    .:||   ..|||.|       .:.|.
  Rat   497 SVHTCVHPSTTGQLVIE--SVPPNVVEGGDVLLLV----HNMPENLQSFSWYK-------GVAIV 548

  Fly   683 EKKEEFYSLLVF--KDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTI 745
            .:.|...:::..  ..:...|||:.|.|:
  Rat   549 NRHEISRNIIASNRSTLGPAHSGRETIYS------------------------------------ 577

  Fly   746 SINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKT 810
                                             |.||||:.||:.|.|.|.....|.........
  Rat   578 ---------------------------------NGSLLLHNATEEDNGLYTLWTVNRHSETQGIH 609

  Fly   811 IRINVNEPA-----RFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAE 870
            :.|::.:|.     |..:|:..:.|    .|.|.| ...|...:|.|..||..:.|.. |..:::
  Rat   610 VHIHIYKPVAQPFIRVTESSVRVKS----SVVLTC-LSADTGTSIQWLFNNQNLRLTQ-RMLLSQ 668

  Fly   871 MKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEI 925
            .|      .||:|....|.|:|.|||...||           |..:...|..|::
  Rat   669 TK------CQLSIDPVRREDAGEYRCEVSNP-----------VSSKTSLPVSLDV 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	27/111 (24%)
		Ig	264..334	CDD:143165	21/88 (24%)
		I-set	345..433	CDD:254352	22/105 (21%)
		Ig	358..431	CDD:143165	20/90 (22%)
		Ig	456..533	CDD:143165	23/119 (19%)
		IGc2	553..619	CDD:197706	15/84 (18%)
		I-set	634..724	CDD:254352	21/99 (21%)
		ig	645..712	CDD:278476	16/71 (23%)
		IG_like	734..815	CDD:214653	12/80 (15%)
		Ig	745..815	CDD:299845	12/69 (17%)
		I-set	820..913	CDD:254352	25/92 (27%)
		Ig	838..920	CDD:299845	22/81 (27%)
		FN3	917..1033	CDD:238020	2/9 (22%)
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Ceacam3	NP_036834.2	Ig_CEACAM_D1	36..140	CDD:143251	24/108 (22%)
		IG_like	45..137	CDD:214653	23/96 (24%)
		Ig_CEACAM_D1	156..260	CDD:143251	28/126 (22%)
		Ig_CEACAM_D1	276..380	CDD:143251	18/103 (17%)
		Ig_CEACAM_D1	394..498	CDD:143251	19/107 (18%)
		Ig_CEACAM_D1	510..614	CDD:143251	33/185 (18%)
		Ig	616..706	CDD:299845	29/112 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000