DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and Lrit1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_647547.2	Gene:	Lrit1 / 246214	RGDID:	628607	Length:	623	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	96/500 - (19%)
Similarity:	167/500 - (33%)	Gaps:	169/500 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   690 SLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIM--LGNTISINCEAE 752
            |.|:|  |.||    ..|.:..:.|.|.: ::|::|........|..|:|:  ||:|:.:.|.|.
  Rat   221 SNLIF--IEAR----LRCGSPRSLAGVAF-SQLELRKCQSPELRPGVTSIISPLGSTVLLRCGAT 278

  Fly   753 GYPIPTITWFKGQGKGSKDFKPLSMRNHS---------LLLNLATDN--DEGYYMCQATNEIGAG 806
            |.|.|.::|.:..|      :||:...|.         .||:|...:  |.|.|:|||.|.:||.
  Rat   279 GIPGPEMSWRRANG------RPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGAS 337

  Fly   807 LKKTIRINVNEP--------------ARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQN-- 855
             :..|.:.|.||              ||..:.|.  ::..|:.:.........||:.:....:
  Rat   338 -ETLISLIVTEPQTSTEYTGIPGALWARTGEGAE--AAAYNNKLVARHVPHVPEPVALATKPSVP 399

  Fly   856 --NGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPD 918
              ...:.|.||:..:.              |...|..|                       |..:
  Rat   400 SIKEELPLQNFQMDVP--------------GEFSREPS-----------------------EHQE 427

  Fly   919 TPSHLEIFEVGS--RTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVS 981
            |.....:..||.  .:|.|.|:.|..||:...|.|.               |..|..:...:.|.
  Rat   428 TQMVRSLKVVGDTYHSVSLVWKAPQAGNTTAFSVLY---------------AVFGQRDMRRMTVE 477

  Fly   982 LPSTSISRSYDSDLRESAIVAGLTPATTFL--IRMQAINEIERSAYTEAIVLKTQEEAPTEAPSN 1044
            ...||::            :.||.|.|.::  :.::.:...:.    :.::..|.|....|....
  Rat   478 AGKTSVT------------IEGLAPKTKYVACVCVRGLVPTKE----QCVIFSTDEVVDAEGTQR 526

  Fly  1045 V------------------------------QVQTGGESELIVTWQIPPRESWNGELIGYTVNCS 1079
            :                              :.:.||.:|....:.       |.|.:|::.:.|
  Rat   527 LINMVVISVAAIIALPPTLLVCCGALRRRCHKCRAGGSAEASGAYV-------NLERLGHSEDGS 584

  Fly  1080 EEKQNINF-----ISVVNSSLKSTIVSGWATTKATLRGLRKYSRY 1119
            ||....:.     :....|||.|.::.        :||.|:.:.|
  Rat   585 EELSRSSLSEADRLLSARSSLDSQVLG--------VRGGRRINEY 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352	10/33 (30%)
		ig	645..712	CDD:278476	7/21 (33%)
		IG_like	734..815	CDD:214653	29/93 (31%)
		Ig	745..815	CDD:299845	23/80 (29%)
		I-set	820..913	CDD:254352	11/96 (11%)
		Ig	838..920	CDD:299845	9/85 (11%)
		FN3	917..1033	CDD:238020	20/119 (17%)
		FN3	1040..1142	CDD:238020	17/114 (15%)
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Lrit1	NP_647547.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..128
		LRR_8	131..>176	CDD:290566
		LRR_4	131..172	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378
		TPKR_C2	201..>240	CDD:301599	7/24 (29%)
		Ig	257..345	CDD:299845	29/94 (31%)
		IG_like	267..345	CDD:214653	26/84 (31%)
		FN3	431..501	CDD:214495	19/96 (20%)
		LRR 6	525..548		0/22 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900