DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Ncam1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	994	Identity:	217/994 - (21%)
Similarity:	369/994 - (37%)	Gaps:	236/994 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 VSVHILPQVQIVNSGGTANFNCTTTGSAIDA-IDWLH-NGKPLQANN---ALTTGRDNIRFLSKS 400
            :.|.|:|....::.|.:..|.|...|.|.|. |.|.. ||:.|..|.   ::....|:     .|
  Rat    20 LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDD-----SS 79

  Fly   401 SLLVQNVGRRDRGVYQCLVENQRAS-AQAMAELKLGDTVPELIY--TFIEQNVRPGPLISLKCSA 462
            :|.:.|....|.|:|:|:|..:..: ::|...:|:   ..:|::  ....|..:.|....:.|..
  Rat    80 TLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKI---FQKLMFKNAPTPQEFKEGEDAVIVCDV 141

  Fly   463 SGSPPPQFAWLLDSQPIM---DVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKC----V 520
            ..|.||...|....:.::   ||         :|:.:|.   ::|.|..::..|.|.|:|    :
  Rat   142 VSSLPPTIIWKHKGRDVILKKDV---------RFIVLSN---NYLQIRGIKKTDEGTYRCEGRIL 194

  Fly   521 ASNSMGSVQHSARLNVYGPPYVRA---IGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTS 582
            |...:........:||  ||.|:|   |....|..|:.:.:.|...|:|...:.|.|..:.:...
  Rat   195 ARGEINFKDIQVIVNV--PPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENE 257

  Fly   583 NHYELASV--ADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNL 645
            ...:...:  .|..:|.|:||:. .|:..|.||..::|||: ...:.|.|.:.|.|...:....:
  Rat   258 EEDDEKHIFSDDSSELTIRNVDK-NDEAEYVCIAENKAGEQ-DASIHLKVFAKPKITYVENQTAM 320

  Fly   646 QEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQIT----EKKEEF-----------YSLLVFK 695
            :...:..:||..|...:| ..:|:....:|.|..:.:    ||:|..           .|.|..|
  Rat   321 ELEEQVTLTCEASGDPIP-SITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLK 384

  Fly   696 DISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTIT 760
            .|....:|:|.|.|||...:.:.:..|:|:.||:.: .|:......||.::|.||...||..||:
  Rat   385 SIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQ-GPVAVYTWEGNQVNITCEVFAYPSATIS 448

  Fly   761 WFK-GQGKGSKDFKPLSMRN--HSLLLNLATD--NDEGYYMCQATNEIGAGLKKTIRINVNEPAR 820
            ||: ||...|.::..:.:.|  .:..|.:..|  ||.|.|.|.|.|.||....:.|.:..:.|:
  Rat   449 WFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPS- 512

  Fly   821 FEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKT------------ 873
                  :.|..|.:|.:.....:.|||      :..|.:.:..::   ||.|:
  Rat   513 ------SPSIDRVEPYSSTAQVQFDEP------EATGGVPILKYK---AEWKSLGEEAWHSKWYD 562

  Fly   874 --EKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHL------------- 923
              |..::..:||...........|..|.|..|..|   ..|..|....|.|.
  Rat   563 AKEANMEGIVTIMGLKPETRYAVRLAALNGKGLGE---ISAATEFKTQPVHSPPPQGEPSAPKLE 624

  Fly   924 -EIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGG---------DWNGH-- 976
             ::.|.|: ::|::..:..||.||:..|||:|:|....:....:....|         |||..
  Rat   625 GQMGEDGN-SIKVNLIKQDDGGSPIRHYLVKYRAKLASEWKPEIRLPSGSDHVMLKSLDWNAEYE 688

  Fly   977 -----------------VINVSLPSTSI--SRSYDSDLRESAIVAGLTPATTFLIRMQ------- 1015
                             |...|...|:|  :.|..:.|...|||..|......|:.:.
  Rat   689 VYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTAGLSTGAIVGILIVIFVLLLVVMDITCYFL 753

  Fly  1016 ---------AIN--------------EIERSAYT-----EAIV-LKTQEE-----------APTE 1040
                     |:|              |..::|::     |.|| ::|:||           .|.|
  Rat   754 NKCGLLMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNE 818

  Fly  1041 APSNVQVQTGGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNS--SLKSTIVSGW 1103
            .....:.:...::...|...:|...         ||..:.:.....|.:..||  |..:|:.|..
  Rat   819 TTPLTEPELPADTTATVEDMLPSVT---------TVTTNSDTITETFATAQNSPTSETTTLTSSI 874

  Fly  1104 ATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAE------GVPEAAP----------- 1151
            |..             |.|:...||..:|. :....|.||.      .||:.||
  Rat   875 APP-------------ATTVPESNSVPAGQ-ATPSKGVTASSSSPPASVPKVAPLVDLSDTPTSA 925

  Fly  1152 ---QNVNCTALSSQSLKIS 1167
               .|::.|.|::|...:|
  Rat   926 PSANNLSSTVLANQGAVLS 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	24/93 (26%)
		Ig	358..431	CDD:143165	21/78 (27%)
		Ig	456..533	CDD:143165	16/83 (19%)
		IGc2	553..619	CDD:197706	15/67 (22%)
		I-set	634..724	CDD:254352	23/104 (22%)
		ig	645..712	CDD:278476	19/81 (23%)
		IG_like	734..815	CDD:214653	28/85 (33%)
		Ig	745..815	CDD:299845	25/74 (34%)
		I-set	820..913	CDD:254352	18/106 (17%)
		Ig	838..920	CDD:299845	17/95 (18%)
		FN3	917..1033	CDD:238020	36/195 (18%)
		FN3	1040..1142	CDD:238020	18/103 (17%)
		fn3	1150..1237	CDD:278470	7/32 (22%)
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451	26/103 (25%)
		Ig strand B	37..41	CDD:409451	1/3 (33%)
		Ig strand C	51..55	CDD:409451	1/3 (33%)
		Ig strand E	79..83	CDD:409451	2/3 (67%)
		Ig strand F	93..98	CDD:409451	2/4 (50%)
		Ig strand G	107..110	CDD:409451	1/2 (50%)
		IG_like	124..190	CDD:214653	16/77 (21%)
		Ig strand B	135..139	CDD:409353	0/3 (0%)
		Ig strand C	148..152	CDD:409353	0/3 (0%)
		Ig strand E	172..176	CDD:409353	1/3 (33%)
		Ig strand F	186..191	CDD:409353	2/4 (50%)
		IgI_3_NCAM-1	211..308	CDD:143207	26/98 (27%)
		Ig strand B	231..235	CDD:143207	0/3 (0%)
		Ig strand C	244..248	CDD:143207	0/3 (0%)
		Ig strand E	271..275	CDD:143207	1/3 (33%)
		Ig strand F	285..290	CDD:143207	2/4 (50%)
		Ig strand G	298..301	CDD:143207	0/2 (0%)
		IgI_NCAM-1	307..413	CDD:143277	23/106 (22%)
		Ig strand B	326..330	CDD:143277	0/3 (0%)
		Ig strand C	339..343	CDD:143277	0/3 (0%)
		Ig strand E	379..383	CDD:143277	2/3 (67%)
		Ig strand F	393..398	CDD:143277	2/4 (50%)
		Ig strand G	406..409	CDD:143277	0/2 (0%)
		Ig_3	422..494	CDD:404760	24/71 (34%)
		Ig strand B	433..437	CDD:409353	1/3 (33%)
		Ig strand C	446..450	CDD:409353	2/3 (67%)
		Ig strand E	473..477	CDD:409353	1/3 (33%)
		Ig strand F	487..492	CDD:409353	2/4 (50%)
		FN3	509..606	CDD:238020	21/115 (18%)
		fn3	619..701	CDD:394996	16/82 (20%)
		Herpes_BLLF1	<842..1133	CDD:282904	26/126 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900