DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and Lrit1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_666357.2	Gene:	Lrit1 / 239037	MGIID:	2385320	Length:	624	Species:	Mus musculus

Alignment Length:	501	Identity:	99/501 - (19%)
Similarity:	167/501 - (33%)	Gaps:	171/501 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   690 SLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIM--LGNTISINCEAE 752
            |.|:|  |.||    ..|.:..:.|.|.: ::|::|........|..|:|:  ||:|:.:.|.|.
Mouse   222 SNLIF--IEAR----LRCASPRSLAGVAF-SQLELRKCQSPELRPGVTSIISPLGSTVLLRCGAT 279

  Fly   753 GYPIPTITWFKGQGKGSKDFKPLSMRNHS---------LLLNLATDN--DEGYYMCQATNEIGAG 806
            |.|.|.::|.:..|      :||:...|.         .||:|...:  |.|.|:|||.|.:||.
Mouse   280 GIPGPEMSWRRANG------RPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGAS 338

  Fly   807 LKKTIRINVNEP--------------ARFEQSA-----RNISSRRNDPVTLDCHAKGDEPITIGW 852
             :..|.:.|.||              ||..:.|     .|....|:.|...:..|...:|   ..
Mouse   339 -ETLISLIVTEPQTSTGYSGIPGVLWARTGEGAEAAAYNNKLVARHVPHMPEHVALATKP---SM 399

  Fly   853 TQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERP 917
            ......:.|.||:..:.              |...|..|         .:..|:.:..|.|
Mouse   400 PSIKEELALQNFQMDVP--------------GEFSREPS---------EHQEAQMVRSLKV---- 437

  Fly   918 DTPSHLEIFEVGS--RTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINV 980
                      ||.  .:|.|.|:.|..||:...|.|.               |..|..:...:.|
Mouse   438 ----------VGDTYHSVSLVWKAPQAGNTTAFSVLY---------------AVFGHRDMRRMTV 477

  Fly   981 SLPSTSISRSYDSDLRESAIVAGLTPATTFL--IRMQAINEIERSAYTEAIVLKTQEEAPTEAPS 1043
            ....||::            :.||.|.|.::  :.::.:...:.    :.::..|.|....|...
Mouse   478 EPGKTSVT------------IEGLAPKTKYVACVCVRGLVPTKE----QCVIFSTDEVVDAEGTQ 526

  Fly  1044 NV------------------------------QVQTGGESELIVTWQIPPRESWNGELIGYTVNC 1078
            .:                              :.:|||.:|....:.       |.|.:|::.:.
Mouse   527 RLINMVVISVAAIIALPPTLLVCCGALRRRCHKCRTGGSAEASGAYV-------NLERLGHSEDS 584

  Fly  1079 SEEKQNINF-----ISVVNSSLKSTIVSGWATTKATLRGLRKYSRY 1119
            ||.....:.     :....|||.|.::.        :||.|:.:.|
Mouse   585 SEVLSRSSLSEGDRLLSARSSLDSQVLG--------VRGGRRINEY 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352	10/33 (30%)
		ig	645..712	CDD:278476	7/21 (33%)
		IG_like	734..815	CDD:214653	29/93 (31%)
		Ig	745..815	CDD:299845	23/80 (29%)
		I-set	820..913	CDD:254352	15/97 (15%)
		Ig	838..920	CDD:299845	11/81 (14%)
		FN3	917..1033	CDD:238020	19/119 (16%)
		FN3	1040..1142	CDD:238020	18/115 (16%)
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Lrit1	NP_666357.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..>176	CDD:290566
		LRR_4	131..172	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378
		TPKR_C2	201..>241	CDD:301599	7/24 (29%)
		Ig	258..346	CDD:299845	29/94 (31%)
		IG_like	268..346	CDD:214653	26/84 (31%)
		FN3	432..502	CDD:214495	21/110 (19%)
		LRR 6	526..549		0/22 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900