DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and Sdk2

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_766388.2 Gene:Sdk2 / 237979 MGIID:2443847 Length:2176 Species:Mus musculus


Alignment Length:1886 Identity:418/1886 - (22%)
Similarity:663/1886 - (35%) Gaps:506/1886 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   348 QVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDR 412
            :.|:...|......|...||......||||      |..||      ||..:...::.::.|...
Mouse    38 RTQVHLEGNRLVLTCMAEGSWPLEFKWLHN------NRELT------RFSLEYRYMITSLDRTHA 90

  Fly   413 GVYQCLVENQRASAQAMAELKLGDTVPELIY--TFIE----QNVRPGPLISLKC-SASGSPPPQF 470
            |.|:|:|.|:      |..|....|..::.|  :|.|    |:|..|....::. ..|..|.||.
Mouse    91 GFYRCIVRNR------MGALLQRQTEVQVAYMGSFEEGEKRQSVNHGEAAVIRAPRISSFPRPQV 149

  Fly   471 AWLLDSQPI-----MDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQH 530
            .|..|.:.|     :.::|.:...|               :|.|.||.|..|....::..|..:.
Mouse   150 TWFRDGRKIPPSSRIAITLENTLVI---------------LSTVAPDAGRYYVQAVNDKNGDNKT 199

  Fly   531 SARL-----NVYGP-----PYVRAIGPIK---AVAG-EDIIVHCPFAGYPVEQIR--WEKAHQEL 579
            |..:     ||.||     |.:  |.|.|   .||| .::.:.|.....|:.::.  |:|....|
Mouse   200 SQPITLAVENVGGPADPIAPTI--IIPPKNTSVVAGTSEVTMECVANARPLIKLHIVWKKDGAPL 262

  Fly   580 TTSNHYELASVAD-GGQLVIKNVEPGRDQGIYTC--IVRSRAGEEARRDMQLNVNSPP--VIEPF 639
            :       :.::| ..:|.|.|.... |.|.|.|  ::||.:.....|...|:|..||  |.||.
Mouse   263 S-------SGISDYNRRLTIANPTVS-DAGYYECEAMLRSSSVAPVTRGAYLSVLEPPQFVREPE 319

  Fly   640 KFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGK 704
            :......| ....|.|. :.|..|...:|.||.:.:... ::|..|:.....|....:....:|.
Mouse   320 RHITAEME-KVVDIPCR-AKGVPPPSITWYKDAALVEVG-KLTRFKQRSDGGLQISGLLPDDTGM 381

  Fly   705 YTCYASNAAAKVNYTAELQV-RVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQ--- 765
            ..|:|.|||.:...:..|.| .:||.....|:|:.::.|.::.:.||..|.|.|.|||.||:   
Mouse   382 LQCFAHNAAGEAQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERIL 446

  Fly   766 GKGSKDFKPLS-MRNHSLLLNLATDNDEGYYMCQATN-----EIGAGLKKTIRINVNEPARFEQS 824
            ..||......: :.:.|||::....:|.|.|.|.|||     |..|.|....|..:.:|.: :||
Mouse   447 ASGSVQLPRFTLLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQ-DQS 510

  Fly   825 ARNISSRRNDPVTLDCHAKGDEPITIGW----------TQNNGRIDLNNFRFSIAEMKTEKGVDS 879
            .     .:....::.|....|..:|:.:          .:.|.||.|:.              :.
Mouse   511 V-----IKGTQASMVCGVTHDPRVTVRYVWEKDGATLAVETNPRIRLDR--------------NG 556

  Fly   880 QLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSH--LEIFEVGSRTVKLSWRRPFD 942
            .|.|..:...|.|.|.|...:..|...:...|.|::.|..|.|  ..:..|..|.:.|:|.:|||
Mouse   557 SLHISQTWSGDIGTYTCRVLSAGGNDSRNAHLRVRQLPHAPEHPVATLSTVERRAINLTWAKPFD 621

  Fly   943 GNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPA 1007
            ||||::.|:::            ::.....|...:.:|...:||:            :|.||.||
Mouse   622 GNSPLMRYVLE------------MSENNAPWTILLASVDPEATSV------------MVKGLVPA 662

  Fly  1008 TTFLIRMQAINEIERSAY---TEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNG 1069
            .::..|:.|:|::.:..:   ||.:.|  .||.||..|.||.........:::.||.||....||
Mouse   663 RSYQFRLCAVNDVGKGQFSKDTERVSL--PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNG 725

  Fly  1070 ELIGYTVN-C------SEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMN 1127
            .|.||.:. |      ..:.:||....|.|..|:..|:               ::.|.:.:.|.|
Mouse   726 ILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLII---------------WTNYEIEVAAYN 775

  Fly  1128 SFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVH 1192
            |.|.|.:|:.:...|.:|||...|.||:..|.:|.:::.:|..|..||..||.||||::...   
Mouse   776 SAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWE--- 837

  Fly  1193 QIDFPAKLE----IKRTSNLETYLHT-----LHKASNYSIRVLAYTATGDGLASHPLFCQTDDDV 1248
                ||:.|    :....|.:..:|.     |.|.:.|...||.:|..|||..|.|...:|.:||
Mouse   838 ----PAQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSSPQLVRTHEDV 898

  Fly  1249 PDAPAAIKAAALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYP-VTFE 1312
            |.....:....:...|:.:||..|..:|||::.|.:...|..|.....||.:       | ||.|
Mouse   899 PGPVGHLSFNDILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYL-------PNVTLE 956

  Fly  1313 SR--SLAENQMYEFWVSASTS-------------------------------------------- 1331
            .|  .|.....|...|:|.||                                            
Mouse   957 YRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGAPTNLGISNIGPRSVTLQFRPGY 1021

  Fly  1332 -----------------VGEGEPTSVIAQATN--------------------------------- 1346
                             :||||...:|.|..|                                 
Mouse  1022 DGKTSISRWVVEAQVGVIGEGEEWLLIYQLGNEPDARSMEVPDLNPFTYYSFRMRQVNIVGTSPP 1086

  Fly  1347 ---------TRAPARIASFGQVVRKAVGTGLVLECLAV------GNP------------------ 1378
                     .:||..||.....:|.|..|.|.|..:.:      |||                  
Mouse  1087 SQPSRKIQTLQAPPDIAPANVTLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYGRSDGHGKT 1151

  Fly  1379 ---TPRAR------------WL------------------------TRDRPVTFSP--------- 1395
               |.:.|            |.                        ||:...:..|         
Mouse  1152 LSHTVQDRVEREYTIEDLEEWTEYRVQVQAFNAIGSGPWSQAVVGRTRESVPSSGPTNVSALATT 1216

  Fly  1396 --------------------------FYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQ-- 1432
                                      :.|..::...:...|||:.|.:...|....:...|:|  
Mouse  1217 SSSMLVRWSEIPEADRNGLVLGYKVRYKEKDSDSQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVL 1281

  Fly  1433 -YQVIAMKPPSAPQIIVQ---------------YASADSIRVSWDAPDDGGAPLQGYTISYH--- 1478
             :..|....||.|.|:.:               .....|:|:.|..|......:..|.|::.   
Mouse  1282 AFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNA 1346

  Fly  1479 TAGESWSITELLPENNAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANEL 1543
            |...:.::..|.|....:..:|||..:.|:.:::|....|.|.|:|.:.|.|:.:....|.:..:
Mouse  1347 TTANTATVEVLAPSARQYMATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSKPV 1411

  Fly  1544 IATNATCVNLKLSSWQNG--GCS-IHHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPA 1605
            :..........|.||:.|  |.| :.:::|:.|.|...||.:.::.:|:   |..........|.
Mouse  1412 VQQEDVKARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSH---NASAFTVDRLKPF 1473

  Fly  1606 KWYQLRISATNDAGKT--TEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATL 1668
            ..|:.|:.||||.|.:  :|... |.|.:.......|::.........:::....|.|.|     
Mouse  1474 TSYKFRVKATNDIGDSEFSEESE-SLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPSED----- 1532

  Fly  1669 IVVVIITVSIITIALTIKHRRTLCGPIAEGYESRTLPGDYKEDHENRRNQQVYS----ASPVKT- 1728
                  .::.|.:...|::|..|    .:|....||.|......:......:||    ..|..| 
Mouse  1533 ------KINGILLGFRIRYRELL----YDGLRGFTLRGINNPGAKWAELTSLYSMRNLTRPSLTQ 1587

  Fly  1729 --VDKGNESEMYEISPYATFSVNGGRTGAPAK------TPTRA-------VAAQTPLDYTMQFKT 1778
              :|..::...|||......:|..|....|.:      .||.|       .|..|.||.|.:...
Mouse  1588 YELDNLSKHRRYEIRMSIYNAVGEGPLSPPQEVFVGEAVPTAAPQNVAIHSATATQLDVTWEPPP 1652

  Fly  1779 FGHPEGENLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTEDESTL--------SKSMT------- 1828
            ..:..|:......|               .|..||...||...||        .|::|       
Mouse  1653 LDNQNGDIQGYKIY---------------FWEVQRRNLTERVKTLFLAENSVKLKNLTGYTAYMV 1702

  Fly  1829 -IVAGSQAGHSKKSNGGRSAKSSAACS--GVVAGSE-SDTSISPS---TEFSNMPT--YRV---P 1881
             :.|.:.||...:|...|.....||.|  |.|..|| :.||::.|   .:|.|.|.  ||:   |
Mouse  1703 SVAAFNAAGDGPRSTPTRGQTQQAAPSAPGSVKFSELTTTSVNVSWDAPQFPNGPLEGYRLVYEP 1767

  Fly  1882 C 1882
            |
Mouse  1768 C 1768

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352 21/84 (25%)
Ig 358..431 CDD:143165 19/72 (26%)
Ig 456..533 CDD:143165 17/82 (21%)
IGc2 553..619 CDD:197706 16/71 (23%)
I-set 634..724 CDD:254352 22/91 (24%)
ig 645..712 CDD:278476 14/66 (21%)
IG_like 734..815 CDD:214653 29/89 (33%)
Ig 745..815 CDD:299845 26/78 (33%)
I-set 820..913 CDD:254352 17/102 (17%)
Ig 838..920 CDD:299845 17/91 (19%)
FN3 917..1033 CDD:238020 30/120 (25%)
FN3 1040..1142 CDD:238020 26/108 (24%)
fn3 1150..1237 CDD:278470 29/95 (31%)
FN3 1263..1345 CDD:238020 29/145 (20%)
Ig 1350..1436 CDD:299845 25/186 (13%)
IG_like 1358..1436 CDD:214653 22/178 (12%)
FN3 1441..1530 CDD:238020 23/106 (22%)
FN3 1542..1620 CDD:238020 20/80 (25%)
Sdk2NP_766388.2 IG_like 44..113 CDD:214653 22/86 (26%)
IGc2 44..102 CDD:197706 19/75 (25%)
IG_like 124..207 CDD:214653 20/97 (21%)
Ig 136..192 CDD:299845 15/70 (21%)
IG_like 226..308 CDD:214653 21/89 (24%)
IGc2 237..290 CDD:197706 13/60 (22%)
I-set 312..401 CDD:254352 22/91 (24%)
Ig 330..398 CDD:143165 16/69 (23%)
I-set 406..496 CDD:254352 29/89 (33%)
Ig 420..496 CDD:299845 26/75 (35%)
Ig 506..590 CDD:299845 17/103 (17%)
IG_like 506..590 CDD:214653 17/103 (17%)
FN3 594..685 CDD:238020 27/114 (24%)
FN3 697..790 CDD:238020 26/107 (24%)
FN3 798..894 CDD:238020 31/102 (30%)
FN3 899..987 CDD:238020 24/94 (26%)
FN3 997..1091 CDD:238020 7/93 (8%)
FN3 1103..1198 CDD:238020 12/94 (13%)
FN3 1205..1294 CDD:238020 12/88 (14%)
FN3 1305..1398 CDD:238020 19/92 (21%)
FN3 1404..1488 CDD:238020 21/86 (24%)
FN3 1507..1620 CDD:238020 23/127 (18%)
FN3 1630..1723 CDD:238020 22/107 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1712..1734 6/21 (29%)
FN3 1728..1809 CDD:238020 15/41 (37%)
FN3 1841..1920 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2013..2032
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2043..2070
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2102..2176
PDZ-binding. /evidence=ECO:0000269|PubMed:20219992 2170..2176
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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