DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Ptprq

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001357916.1	Gene:	Ptprq / 237523	MGIID:	1096349	Length:	2301	Species:	Mus musculus

Alignment Length:	2067	Identity:	418/2067 - (20%)
Similarity:	674/2067 - (32%)	Gaps:	719/2067 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 LVTNT--------LNGERQRSDAVMLQVKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNP 274
            |.||.        |.|||..|..::     ||.|..|....:.:.  :|.:..:|   |     |
Mouse    50 LATNVSKPGPPVFLAGERVGSAGIL-----LSWNTPPNPNGRIIS--YVVKYKEV---C-----P 99

  Fly   275 FPIFTWYRVSDSAALYPIPSSQRVILSR----TLLLIKNADERDAGKWICQASNQFGEQRIE--- 332
            :....:.||...      |.|..|:|:.    |...||.|.|..||  |...|:.|..|..|
Mouse   100 WMQTAYTRVRAK------PDSLEVLLTNLNPGTTYEIKVAAENSAG--IGVFSDPFLFQTAESAP 156

  Fly   333 ---IRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNI 394
               :.|:|.:                  .|:      ||::.|.:|    |.|.|..:|:.:.::
Mouse   157 GKVVNLTVEA------------------LNY------SAVNLIWYL----PRQPNGKITSFKISV 193

  Fly   395 RFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPEL---IYTFIEQNVRPGPLI 456
            :. ::|.::|::|..:                   .|..|...:||.   ..:|:.....|.|.:
Mouse   194 KH-ARSGIVVKDVSIK-------------------VEDLLSGKLPECNENSDSFLWSTTSPSPTL 238

  Fly   457 SLKCSASGSPPPQFAWLLDS-----------QPIMDVSLHHR------FAIGQFVDMSGDVISHL 504
            |     ..:||.:...|.::           :||..|..|.|      |.:......:|.:.|.:
Mouse   239 S-----RATPPLRTTHLSNTLARNKISSVWKEPISFVVTHLRPYTTYLFEVSAVTTEAGYIDSTI 298

  Fly   505 NISHVRPDDGGLYKCVASNSMGSV-------------QHSARLNVYGPPYVRAIGPIKAVAGED- 555
            ..:.....:|....|:..|..|..             :.|.|:.:|||     .|.|...:.:|
Mouse   299 VRTPESVPEGPPQNCITGNVTGKAFSISWDPPAIVTGKFSYRVELYGP-----TGRILDNSTKDL 358

  Fly   556 --IIVH-CPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSR 617
              :..| .||..|.|                 |..|..:.|       |.|..:..::|
Mouse   359 RFVFTHLTPFTMYDV-----------------YVAAETSAG-------VGPKSNLSVFT------ 393

  Fly   618 AGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSL--Q 680
                           ||.:....|...:.|....:|.           .||:|...  |:.:  |
Mouse   394 ---------------PPDVPGAVFDLQIVEVEATEIR-----------VSWRKPRQ--PNGIISQ 430

  Fly   681 ITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTI 745
            ...|.....|.::.::.......:|          :|               .||...||  |.:
Mouse   431 YRVKVSVLESGVILENTLLTGQDEY----------IN---------------NPMTPEIM--NLV 468

  Fly   746 SINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKT 810
            .          |.|.:::|.|:.|.|.       |||...:...:...:
Mouse   469 D----------PMIGFYEGSGEMSSDL-------HSLASFIYNSHPHDF---------------- 500

  Fly   811 IRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEK 875
                   |||     ..:..:|:             |:.:. |:|....|:.....|....:...
Mouse   501 -------PAR-----TRVEDQRS-------------PVVVA-TRNQYMTDIAAEHLSYVIRRLVP 539

  Fly   876 GVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIF---EVGSRTVKLSW 937
            ..:..:::        ..:..:.|.|      ...|.|:.|...||.::|.   .:.|.::.|.|
Mouse   540 FTEHTISV--------SAFTVMGEGP------PTVLTVRTREQVPSSIQIINYKNISSSSILLYW 590

  Fly   938 RRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVA 1002
            ..|...|..:..|.:....|.                   .|.:...|::..|:        ::.
Mouse   591 DPPEYPNGKITHYTIYAMELD-------------------TNRAFQMTTVDNSF--------LIT 628

  Fly  1003 GLTPATTFLIRMQAINEIERSAYTEA--IVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRE 1065
            ||...|.:.:|:.|...:..|:.:|.  :.::|.|:.|..:|.:|:|.....|||.:||.  |.|
Mouse   629 GLKKYTRYKMRVAASTHVGESSLSEENDLFVRTPEDEPESSPQDVKVTDVSPSELSLTWS--PPE 691

  Fly  1066 SWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFG 1130
            ..||.:|.|.|    ..||.:.:.|.|:|          ||..||..|:.|:.|.::|::....|
Mouse   692 KPNGIIIAYEV----FYQNADALFVKNTS----------TTNITLSDLKPYTLYNISIQSYTRLG 742

  Fly  1131 SGPWSAAIFGT-TAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKI-LYRPIVHQ 1193
            .|..|:::... |:|.||::||:|:....:||:.::|.:|.|  :...||||.|.| |.|...|:
Mouse   743 HGNQSSSLLSVRTSETVPDSAPENITYKNISSEEIEIFFLPP--RSPNGIIQKYTIYLKRSNSHE 805

  Fly  1194 IDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAA-IKA 1257
                  .....|::|...:..|.|.::|.|.|.|.|..|:|:.|.|:...|::|.||:|.. ...
Mouse   806 ------ARTIETTSLTLTIGGLKKYTHYVIEVSASTLKGEGVRSMPISILTEEDAPDSPPQNFSV 864

  Fly  1258 AALTADSILISWLTPKNRNGIISHYTVY---------------SRE----------------AGR 1291
            ..|:..::::||..|...||||.:||||               |.|                :.|
Mouse   865 KQLSGVTVMLSWQPPLEPNGIILYYTVYVWDKVSLKTINATEVSLELSDLDYHADYSAYVTASTR 929

  Fly  1292 KGQAKT---------------------HMVR-------------VDENG----YPVTFESRS--- 1315
            .|..||                     |.|.             |..||    |.|.:::.|
Mouse   930 FGDGKTRSSVINFRTPEGEPSDPPKDVHYVNLSSSSIILFWTPPVKPNGIIQYYSVYYQNTSSTF 994

  Fly  1316 ------------------------LAENQMYEFWVSASTSVGEGEPTS-VIAQATNTRAPARIAS 1355
                                    ||....|.||::|||.||.|..:| ||...|:...|.  ..
Mouse   995 VQNFTLLEVTQEPGNVTVSARIYKLAVFSYYTFWLTASTLVGNGNKSSDVIHVYTDQDIPE--GG 1057

  Fly  1356 FGQVVRKAVGT--------------GLVLECLAVG--NPTPRARWLTRDRPVTFSPFYEVTNEGN 1404
            .|.:..:::.:              |||...:::.  ...||.|     ||    |.  .|.|.:
Mouse  1058 VGNLTYESLSSTAINVSWTPPSQPNGLVFYYVSLNLQQSPPRHR-----RP----PL--TTYENS 1111

  Fly  1405 LKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKP----PSAPQIIVQY--ASADSIRVSWDAP 1463
            :....:|......:..|.:...|..|.....:.:|.    |..|.||..:  .|:.||.:|||.|
Mouse  1112 IYFDNLEKYTDYIFKITPSTEKGFSETYTAQLHIKTEEDVPDTPPIINTFKNLSSTSILLSWDPP 1176

  Fly  1464 DDGGAPLQGYTISYH-------------TAGESWSITELLPENNAFTISGLKCGNQYIIKMSAHN 1515
                ....|..:|||             |:|....:.||.|    ||:        |....:|..
Mouse  1177 ----LKPNGAILSYHLTLQGTHANRTFVTSGNHIVLEELSP----FTL--------YSFLAAART 1225

  Fly  1516 MVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLS----SWQ-----NGGCSIHHFSI- 1570
            |.|.| .|..:..:|...|..||      ..|.|.:|....    :|.     .|...::.|.|
Mouse  1226 MKGLG-PSSILFFYTDESAPLAP------PQNLTLINYTSDFVWLTWSPSPLPGGIVKVYSFKIH 1283

  Fly  1571 EHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGK-----------TTEH 1624
            ||..  |   ||...:||..:.:.:   .....|...|.:.:||....|.           |.|.
Mouse  1284 EHET--D---TVFYKNISGFQTDAK---LAGLEPVSTYSISVSAFTKVGNGNQFSNVVKFTTQES 1340

  Fly  1625 YHFSTTNI-------DGITI---PPPSVFPSENDLMNNLI---------NSTNPTSGDWFATLIV 1670
            ...:..||       ..:::   ||...        |.:|         |||..:..|...|...
Mouse  1341 VPDAVQNIACVARDWQSVSVMWDPPRKA--------NGIIIHYMITVEGNSTKVSPRDPMYTFTK 1397

  Fly  1671 VVIITVSIITIALTIKHRRTLCGPIAEGYESR----TLP-------------------------- 1705
            ::..|..|..:..:     |..|   ||.||:    |||
Mouse  1398 LLANTSYIFEVRAS-----TSAG---EGNESQCNVSTLPETVPSVPTNTAFSNVQSTSVTLRWIK 1454

  Fly  1706 --------GDYK----------------EDHENRRNQQVYSASPVKTVDKG-NESEMYEISPYAT 1745
                    .:||                |..|::..|.:|.|:..:...:| .:.:.|.....|
Mouse  1455 PDTILGYFQNYKITTQLRAQKCREWEPEECVEHQEVQYLYEANQTEDTVRGLKKFQWYRFQVAA- 1518

  Fly  1746 FSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKTFGHPEG--ENLNATAYPLLPSSGFGHVKSKSS 1808
             |.|.|...|.:...|:.:.              |.|:|  ||:...|     :|.||   ...|
Mouse  1519 -STNAGYGNASSWISTQTLP--------------GPPDGPPENVRVVA-----TSPFG---INIS 1560

  Fly  1809 WHK------QRYYNTEDESTLSKSMTI--VAGSQAGHSKKSNG----GRSAKSSAACSGVVAGSE 1861
            |::      ..:|..:.:|..:.:..|  |..::...:.:.|.    .|.:....|..|.|:|:.
Mouse  1561 WNEPAIITGPTFYLIDVKSVDNDNFNISFVKSNEENKTTEINDLEVFTRYSVVITAFVGNVSGAY 1625

  Fly  1862 SDTSIS-----------PSTEFSNMPTYRVPCKSSRSSDGRAVVDMFRPDSSTESNND------- 1908
            :|...|           |....:||...::|.:.::....      |.|.|....|..
Mouse  1626 TDGKSSAEVIITTLESVPKDPPNNMTFQKIPDEVTKFQLS------FLPPSQPNGNIQVYQALVY 1684

  Fly  1909 -QGSPAPERRHN------TPRHVLGMGMAMGLGGGGGGGV------GGGNGP 1947
             :..|...:.||      |...|:  .|..||.||....:      ..|.||
Mouse  1685 REDDPTAVQIHNLSIIQKTDTSVI--AMLEGLKGGHTYNISVYAINSAGAGP 1734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	24/100 (24%)
		Ig	264..334	CDD:143165	21/79 (27%)
		I-set	345..433	CDD:254352	13/87 (15%)
		Ig	358..431	CDD:143165	12/72 (17%)
		Ig	456..533	CDD:143165	17/106 (16%)
		IGc2	553..619	CDD:197706	12/69 (17%)
		I-set	634..724	CDD:254352	13/91 (14%)
		ig	645..712	CDD:278476	10/68 (15%)
		IG_like	734..815	CDD:214653	14/80 (18%)
		Ig	745..815	CDD:299845	9/69 (13%)
		I-set	820..913	CDD:254352	10/92 (11%)
		Ig	838..920	CDD:299845	10/81 (12%)
		FN3	917..1033	CDD:238020	20/120 (17%)
		FN3	1040..1142	CDD:238020	31/102 (30%)
		fn3	1150..1237	CDD:278470	28/87 (32%)
		FN3	1263..1345	CDD:238020	39/178 (22%)
		Ig	1350..1436	CDD:299845	17/101 (17%)
		IG_like	1358..1436	CDD:214653	15/93 (16%)
		FN3	1441..1530	CDD:238020	28/103 (27%)
		FN3	1542..1620	CDD:238020	18/87 (21%)
Ptprq	NP_001357916.1	FN3	57..151	CDD:238020	29/116 (25%)
		FN3	308..393	CDD:238020	22/113 (19%)
		fn3	399..>441	CDD:365830	9/54 (17%)
		FN3	570..654	CDD:238020	19/110 (17%)
		fn3	668..744	CDD:365830	29/91 (32%)
		FN3	762..850	CDD:238020	30/95 (32%)
		fn3	857..934	CDD:365830	17/76 (22%)
		FN3	951..1049	CDD:238020	22/97 (23%)
		FN3	1056..1137	CDD:238020	15/91 (16%)
		FN3	1152..1233	CDD:238020	27/97 (28%)
		FN3	1247..1337	CDD:238020	20/103 (19%)
		FN3	1342..1421	CDD:238020	18/94 (19%)
		FN3	1432..1535	CDD:238020	15/104 (14%)
		FN3	1542..1638	CDD:238020	21/103 (20%)
		FN3	1645..1734	CDD:238020	18/96 (19%)
		UP_III_II	1759..1928	CDD:297589
		R-PTPc-Q	2033..2256	CDD:350464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900