DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and Ntm

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_001344522.1 Gene:Ntm / 235106 MGIID:2446259 Length:367 Species:Mus musculus


Alignment Length:357 Identity:85/357 - (23%)
Similarity:140/357 - (39%) Gaps:65/357 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   641 FPK-----NLQEGGRAQITCAVSSGDMPIYFSW---------KKDDSSIPSSLQITEKKEEFYSL 691
            |||     .:::|..|.:.|.:.:....:  :|         ..|...:...:.:....:..||:
Mouse    38 FPKAMDNVTVRQGESATLRCTIDNRVTRV--AWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSI 100

  Fly   692 LVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPI 756
            .: :::.....|.|||..............|.|:|:|:......|.:|..||.||:.|.|.|.|.
Mouse   101 EI-QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIATGRPE 164

  Fly   757 PTITWF----KGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNE 817
            ||:||.    |..|..|:|        ..|.:...|....|.|.|.|:|::.|.:.:.:::.||.
Mouse   165 PTVTWRHISPKAVGFVSED--------EYLEIQGITREQSGEYECSASNDVAAPVVRRVKVTVNY 221

  Fly   818 PARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVD---- 878
            |. :...|:..........||.|.|.........|.:::.|:           ::.:|||.    
Mouse   222 PP-YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWFKDDKRL-----------VEGKKGVKVENR 274

  Fly   879 ---SQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLS-WRR 939
               |:||..:...||.|.|.|:|.|..|.....|.|.....|.:.:.|:  ||  :|..|: |:.
Mouse   275 PFLSKLTFFNVSEHDYGNYTCVASNKLGHTNASIMLFELNEPTSSTLLQ--EV--KTTALTPWKG 335

  Fly   940 P------FDGNSP------VLSYLVQYQALKY 959
            |      .:|.|.      :|..||.:..||:
Mouse   336 PGAVSEVNNGTSRRAGCIWLLPLLVLHLLLKF 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352
Ig 358..431 CDD:143165
Ig 456..533 CDD:143165
IGc2 553..619 CDD:197706
I-set 634..724 CDD:254352 15/96 (16%)
ig 645..712 CDD:278476 11/75 (15%)
IG_like 734..815 CDD:214653 26/84 (31%)
Ig 745..815 CDD:299845 22/73 (30%)
I-set 820..913 CDD:254352 23/99 (23%)
Ig 838..920 CDD:299845 22/88 (25%)
FN3 917..1033 CDD:238020 15/56 (27%)
FN3 1040..1142 CDD:238020
fn3 1150..1237 CDD:278470
FN3 1263..1345 CDD:238020
Ig 1350..1436 CDD:299845
IG_like 1358..1436 CDD:214653
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
NtmNP_001344522.1 Ig 44..132 CDD:416386 12/90 (13%)
Ig strand A' 44..49 CDD:409353 0/4 (0%)
Ig strand B 51..59 CDD:409353 2/7 (29%)
CDR1 59..63 CDD:409353 0/3 (0%)
FR2 64..70 CDD:409353 1/7 (14%)
Ig strand C 64..70 CDD:409353 1/7 (14%)
CDR2 71..83 CDD:409353 1/11 (9%)
Ig strand C' 72..76 CDD:409353 0/3 (0%)
Ig strand C' 80..83 CDD:409353 1/2 (50%)
FR3 84..118 CDD:409353 6/34 (18%)
Ig strand D 87..94 CDD:409353 0/6 (0%)
Ig strand E 97..103 CDD:409353 2/6 (33%)
Ig strand F 110..118 CDD:409353 4/7 (57%)
CDR3 119..123 CDD:409353 0/3 (0%)
Ig strand G 123..132 CDD:409353 1/8 (13%)
FR4 125..132 CDD:409353 1/6 (17%)
Ig_3 136..205 CDD:404760 25/76 (33%)
Ig strand A' 144..148 CDD:409353 1/3 (33%)
Ig strand B 151..160 CDD:409353 4/8 (50%)
Ig strand F 197..205 CDD:409353 4/7 (57%)
Ig_3 222..299 CDD:404760 20/88 (23%)
putative Ig strand A 223..229 CDD:409353 0/6 (0%)
Ig strand B 239..243 CDD:409353 2/3 (67%)
Ig strand C 252..256 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 2/3 (67%)
Ig strand F 292..297 CDD:409353 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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