DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam3 and IGSF9B

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_001264214.1 Gene:IGSF9B / 22997 HGNCID:32326 Length:1437 Species:Homo sapiens


Alignment Length:1880 Identity:372/1880 - (19%)
Similarity:558/1880 - (29%) Gaps:701/1880 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   261 GNDVHLPCN----IQGNPFP-IFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWIC 320
            |..|.|.|:    :.|.|.| :..|::..     .|||           :.||            
Human    38 GESVVLRCDVIHPVTGQPPPYVVEWFKFG-----VPIP-----------IFIK------------ 74

  Fly   321 QASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANN 385
                 ||            |...|:.|:.     .|.|:               ||:        
Human    75 -----FG------------YYPPHVDPEY-----AGRAS---------------LHD-------- 94

  Fly   386 ALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQC---LVENQRASAQAMAELKLGDTVPELIYTFIE 447
                         |:||.::.|...|:|.|:|   :::.|..:....:.:.|....|.   ||.|
Human    95 -------------KASLRLEQVRSEDQGWYECKVLMLDQQYDTFHNGSWVHLTINAPP---TFTE 143

  Fly   448 Q-----NVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNIS 507
            .     ..:.|..|::.|:|.|:|.|...||.:...:        .|.|::....|.    |.::
Human   144 TPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLL--------GASGKYQVSDGS----LTVT 196

  Fly   508 HVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGP---IKAVAGEDIIVHCPFAGYPVE- 568
            .|..:|.|.|.|.|.:..|...|:..|.|.|||::  :.|   |.....:|.::.|....||.. 
Human   197 SVSREDRGAYTCRAYSIQGEAVHTTHLLVQGPPFI--VSPPENITVNISQDALLTCRAEAYPGNL 259

  Fly   569 QIRWEKAHQELTTSNHYEL-ASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNV-- 630
            ...|....:.:...|..:| ..:...|.|:|..|:| .|.|.|||:..:..|........|.|  
Human   260 TYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKP-EDSGKYTCVPSNSLGRSPSASAYLTVQY 323

  Fly   631 -----NSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSI------------PSS 678
                 |.||||       .:..|....|.|.|.:........|.||...:            ..|
Human   324 PARVLNMPPVI-------YVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMEDGS 381

  Fly   679 LQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQV--------RVAPRWRYEPM 735
            ::|.|..||..             |.|||...|....:..:|..::        .|.|.|.|.. 
Human   382 IRIEEATEEAL-------------GTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQ- 432

  Fly   736 DTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQAT 800
                ..|..:.|.|.|.|.|.|.|||.| .||.|:. |..::.:.||.....:..|.|.:.|.||
Human   433 ----EAGRELLIPCAAAGDPFPVITWRK-VGKPSRS-KHSALPSGSLQFRALSKEDHGEWECVAT 491

  Fly   801 NEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFR 865
            |.:.:                              :|...|      :|:               
Human   492 NVVTS------------------------------ITASTH------LTV--------------- 505

  Fly   866 FSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGS 930
                             ||.|                              |..|..:.: :|..
Human   506 -----------------IGTS------------------------------PHAPGSVRV-QVSM 522

  Fly   931 RTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHG---SLAAAG-GDWNGHVINVSLPSTSISRSY 991
            .|..:||...:||.              |.|:..   ..|..| .||      :||| .....|:
Human   523 TTANVSWEPGYDGG--------------YEQTFSVWMKRAQFGPHDW------LSLP-VPPGPSW 566

  Fly   992 DSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELI 1056
                   .:|..|.|.|.:...:.|.|::..||::|.:.:.|. ..|...|         |..::
Human   567 -------LLVDTLEPETAYQFSVLAQNKLGTSAFSEVVTVNTL-AFPITTP---------EPLVL 614

  Fly  1057 VTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAV 1121
            ||   |||        ....|.:::...::::...|.|.                   ...||.:
Human   615 VT---PPR--------CLIANRTQQGVLLSWLPPANHSF-------------------PIDRYIM 649

  Fly  1122 TIRAMNSFGSGPWSA---AIFGTTAEGVPEAAPQNV------------------NCTALSSQSLK 1165
            ..|....     |..   .|.||..|...:...|:.                  |...:||..: 
Human   650 EFRVAER-----WELLDDGIPGTEGEFFAKDLSQDTWYEFRVLAVMQDLISEPSNIAGVSSTDI- 708

  Fly  1166 ISWLEPPLQFHGGIIQGYKILYRP----IVHQIDFPA-----------------KLEIKR----- 1204
              :.:|.|...|        |.||    ||..|.|.|                 |.::||     
Human   709 --FPQPDLTEDG--------LARPVLAGIVATICFLAAAILFSTLAACFVNKQRKRKLKRKKDPP 763

  Fly  1205 ------TSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTAD 1263
                  ..:||:.|.: .|.|..|||.|...:            ::.|| ...|||.:..:.|.:
Human   764 LSITHCRKSLESPLSS-GKVSPESIRTLRAPS------------ESSDD-QGQPAAKRMLSPTRE 814

  Fly  1264 SILISWLTPKNRNGIIS-HYTVYSREAGRKGQAKTHMVRVDENGYPV--------TFESRSL--- 1316
            ..|.  |..|.:..|.| .|:|...||..:......::....:|..|        :.:||.:   
Human   815 KELS--LYKKTKRAISSKKYSVAKAEAEAEATTPIELISRGPDGRFVMDPAEMEPSLKSRRIEGF 877

  Fly  1317 ---AENQMY-EFWVSASTSVGEGEPTSVIA-----------QATNTRAPARIASFGQVVRKAVGT 1366
               .|..|| ||..|...:.....||||.|           |.:....||....|.....:..| 
Human   878 PFAEETDMYPEFRQSDEENEDPLVPTSVAALKSQLTPLSSSQESYLPPPAYSPRFQPRGLEGPG- 941

  Fly  1367 GLVLECLAVGN---PTPRA-------RWLTRDRP--VTFSPFYEVTNEGNLKIHRVEGSLSGNYT 1419
            ||.....|.|.   |.||.       .:|:...|  |...|||         :..|...||    
Human   942 GLEGRLQATGQARPPAPRPFHHGQYYGYLSSSSPGEVEPPPFY---------VPEVGSPLS---- 993

  Fly  1420 CTANNLFGSDEIQYQVIAMKP---------PSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTI 1475
                          .|::..|         |:.|:...:.||..::.:: ..|..|.:|      
Human   994 --------------SVMSSPPLPTEGPFGHPTIPEENGENASNSTLPLT-QTPTGGRSP------ 1037

  Fly  1476 SYHTAGESWSITELLPENNAFTISGLK------------CGNQYIIKMSAHNMVG---------- 1518
                  |.|...|       |...||:            |.....::..|....|          
Human  1038 ------EPWGRPE-------FPFGGLETPAMMFPHQLPPCDVPESLQPKAGLPRGLPPTSLQVPA 1089

  Fly  1519 --SGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNGGCSIHHFSIEHRPL------ 1575
              .|:.|.|.   .||.|.::|....:.|..|       :.||:            ||:      
Human  1090 AYPGILSLEA---PKGWAGKSPGRGPVPAPPA-------AKWQD------------RPMQPLVSQ 1132

  Fly  1576 GDIRWTVVTSDI------SNAEENRENLIFCDFLPAKWY--QLRISATNDAGKTTEHYHFSTTNI 1632
            |.:|.|.....|      ..||...........|..:||  |.|...:....:..|      .::
Human  1133 GQLRHTSQGMGIPVLPYPEPAEPGAHGGPSTFGLDTRWYEPQPRPRPSPRQARRAE------PSL 1191

  Fly  1633 DGITIPPPSVFPSENDLMNNLINS------TNPTSGDWFATLIVVVIITVSIITIALTIKHRRTL 1691
            ..:.:.|..:.|.....:::...|      ..|..|         ::....:..|        ||
Human  1192 HQVVLQPSRLSPLTQSPLSSRTGSPELAARARPRPG---------LLQQAEMSEI--------TL 1239

  Fly  1692 CGPIAEGYESRTLPGDYKEDHENRRNQQVYSASPVKTVDKGNESEMYEISPYATFSVNGGRTGAP 1756
            ..|.|..:..::.|.               :.||.::...|:.|    ..|...|:...  ||.|
Human  1240 QPPAAVSFSRKSTPS---------------TGSPSQSSRSGSPS----YRPAMGFTTLA--TGYP 1283

  Fly  1757 AKTPTRAVAAQTPLDYTMQFKTFGHPE--GENL--NATAYPLLPSSGF-----GHVKSKSSWHKQ 1812
            :..|..|.|.  |.|....|.....|.  ||.|  ..|..|.||:||.     |:..:.......
Human  1284 SPPPGPAPAG--PGDSLDVFGQTPSPRRTGEELLRPETPPPTLPTSGTLPPAPGNAAAPERLEAL 1346

  Fly  1813 RYYNTEDESTLSKSMTIVAGSQAGHSKKSNGGRSAKSSAACSGVVAGSESDTSISPSTEFSN--- 1874
            :|...:                  ..|||:.| |:||.         ..||.|.|.:.:..|   
Human  1347 KYQRIK------------------KPKKSSKG-SSKSK---------KRSDDSASQTQQLPNSQV 1383

  Fly  1875 -MPTYRVPC--KSSRSSDGRAVVDMFRPDSSTESNN--------DQGSPAPERRHNTPRH 1923
             .|...| |  |..|.|         |||.....::        ||.:......|:.|.|
Human  1384 LWPDEAV-CLRKKKRHS---------RPDPFARLSDLCHRQLPEDQTAILNSVDHDDPGH 1433

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352 15/80 (19%)
Ig 264..334 CDD:143165 14/74 (19%)
I-set 345..433 CDD:254352 14/90 (16%)
Ig 358..431 CDD:143165 12/75 (16%)
Ig 456..533 CDD:143165 20/76 (26%)
IGc2 553..619 CDD:197706 17/67 (25%)
I-set 634..724 CDD:254352 21/101 (21%)
ig 645..712 CDD:278476 16/78 (21%)
IG_like 734..815 CDD:214653 23/80 (29%)
Ig 745..815 CDD:299845 22/69 (32%)
I-set 820..913 CDD:254352 6/92 (7%)
Ig 838..920 CDD:299845 6/81 (7%)
FN3 917..1033 CDD:238020 27/119 (23%)
FN3 1040..1142 CDD:238020 16/104 (15%)
fn3 1150..1237 CDD:278470 27/136 (20%)
FN3 1263..1345 CDD:238020 25/108 (23%)
Ig 1350..1436 CDD:299845 20/97 (21%)
IG_like 1358..1436 CDD:214653 17/89 (19%)
FN3 1441..1530 CDD:238020 19/112 (17%)
FN3 1542..1620 CDD:238020 17/91 (19%)
IGSF9BNP_001264214.1 IG_like 30..115 CDD:214653 30/162 (19%)
Ig 41..115 CDD:143165 29/159 (18%)
I-set 139..225 CDD:254352 25/100 (25%)
IGc2 153..210 CDD:197706 18/68 (26%)
I-set 229..321 CDD:254352 22/94 (23%)
Ig 235..321 CDD:299845 20/86 (23%)
IG_like 331..414 CDD:214653 22/102 (22%)
Ig <353..414 CDD:299845 14/73 (19%)
IG_like 426..505 CDD:214653 28/121 (23%)
Ig 442..505 CDD:299845 23/100 (23%)
FN3 510..601 CDD:238020 27/119 (23%)
FN3 617..699 CDD:238020 15/113 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 758..817 16/72 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..1081 39/217 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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