DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dscam3 and DSCAM

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_001380.2 Gene:DSCAM / 1826 HGNCID:3039 Length:2012 Species:Homo sapiens


Alignment Length:2070 Identity:632/2070 - (30%)
Similarity:960/2070 - (46%) Gaps:235/2070 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 LLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEA 112
            ::|.:.||..|.|.|.|.||..:.|.|..|.....|||:|.:..||||...||....:.|.:|:.
Human    34 VVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDN 98

  Fly   113 TYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRPYVRVASWHRG 177
            ||.|.|.|.:|.:.|::|.:.||:|..:.|.||:.:...||.|:.||.||..|..|:.|.||.: 
Human    99 TYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEK- 162

  Fly   178 EEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSK 242
                 ..:|.|:|...::.::|.||::.|::||||..:.|:..:...||.::|::..|.|.:   
Human   163 -----DTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD--- 219

  Fly   243 NLAPRTTQKPVMEIHVER----GNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRT 303
               |..:...:::....|    |..|.|||...|:|.|.:.|.:.:     .|:..|.|...:.|
Human   220 ---PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDN-----MPLELSGRFQKTVT 276

  Fly   304 LLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSA 368
            .|||:|....|:|.::|:.||::|..::..||.|...:...|.|:....:.|...:.:|:.||:.
Human   277 GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTE 341

  Fly   369 IDAIDWLHNGKPLQ-ANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAEL 432
            ...:.|..||:.|. ..|...||      ::..:|::.::.:.|.|.|||.|...:.|||...::
Human   342 DQELSWYRNGEILNPGKNVRITG------INHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQV 400

  Fly   433 KLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMS 497
            .|.|..|::|..|.|:.|.|...:||.|:..|:|.|...|.||..||:....|.   |.|.:...
Human   401 VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHR---ISQMITSE 462

  Fly   498 GDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPF 562
            |:|:|:||||..:..|||:|:|.|:||.|.|.:.||:||.||..:|.:..|.|:||.|..:||..
Human   463 GNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRV 527

  Fly   563 AGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQ 627
            .|||...|:|.| :..|...||.::| ..:.|.|.:.:|:...|:|.|||.|..:......:.:.
Human   528 IGYPYYSIKWYK-NSNLLPFNHRQVA-FENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVH 590

  Fly   628 LNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLL 692
            :.|..||.|:||:||: ...|.|..|.|.|.|||:||..:|:||...||.||.:|....:|.|.|
Human   591 VTVKVPPFIQPFEFPR-FSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSL 654

  Fly   693 VFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIP 757
            ...::|..|:|.|||.|.|.||.|.:.::|.|||.|::..:|.|...:.|..:.:||.|||||:|
Human   655 RISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVP 719

  Fly   758 TITWFKGQGKGSKDFKPLSMR-------NHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINV 815
            ||.|...:|.|...|:|:::.       |.|||:....:.|.|||:|:.:|::||.:.|::.:.|
Human   720 TIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784

  Fly   816 NEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQ 880
            ..||..........:.:.....:.|.|.|::||.:.|.:.:..|:....|:.::..:..:.|.|.
Human   785 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVIST 849

  Fly   881 LTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNS 945
            |.|..:.|.|||.:.|.|.|.||....||.|.|||.|| |..:||.:|.:||:.|.|...|||||
Human   850 LQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD-PPEIEIKDVKARTITLRWTMGFDGNS 913

  Fly   946 PVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYD-SDLRESAIVAGLTPATT 1009
            |:..|.::.:                       |.|....|..|:.| |....||.:..:.|::|
Human   914 PITGYDIECK-----------------------NKSDSWDSAQRTKDVSPQLNSATIIDIHPSST 955

  Fly  1010 FLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGY 1074
            :.|||.|.|.|.:|..:..:.:...|.||...|..|.::......:.|||:.|.:...||.:.||
Human   956 YSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGY 1020

  Fly  1075 TVNCSEEKQNINF---ISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSA 1136
            .:...|.....||   |..|::|..|.:.        ||..|.|:::|.:.::|.|..|:||.|.
Human  1021 QIGYREYSTGGNFQFNIISVDTSGDSEVY--------TLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077

  Fly  1137 AIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKL- 1200
            .|..||.|.||...|:||...|.|.:|:.|||.....:...||:||::::|.         |.| 
Human  1078 EIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW---------ANLM 1133

  Fly  1201 -----EIKR--TSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAA 1258
                 |||.  |:.....|..|.|.:||||:|||:|..|||:.|..:|.:|.:|||..||.:|||
Human  1134 DGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAA 1198

  Fly  1259 ALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTH---MVRVDENGYPVTFESR--SLAE 1318
            |.:|..:.:|||.|...||||..|||:.          :|   .|..:....|.:|..|  :|:.
Human  1199 AASASMVFVSWLPPLKLNGIIRKYTVFC----------SHPYPTVISEFEASPDSFSYRIPNLSR 1253

  Fly  1319 NQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRAR 1383
            |:.|..||.|.||.|.|..:.:|......:|||||.:|...|.......:||.|.|||:|:|..:
Human  1254 NRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVK 1318

  Fly  1384 WL--TRDRP--VTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPSAP 1444
            |:  :...|  ||......:.:.|:..|..|:...||.|:|.|||.:|||||...:....||..|
Human  1319 WMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQP 1383

  Fly  1445 QIIVQYASADSIRVSWDAPDDGGAPLQGYTISY-HTAGESWSITELLPENNAFTISGLKCGNQYI 1508
            ::.|...::.||.:||...|:||:.::||.:.| ....|.|....:.|...::.:..||||..|.
Human  1384 RLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYK 1448

  Fly  1509 IKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIAT-NATCVNLKLSSWQNGGCSIHHFSIEH 1572
            ..::|.|.||.|..||.|...|.||..|.....||.|: |.|.|.|.|..|.:|||.|..|::|:
Human  1449 FTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEY 1513

  Fly  1573 RPLGDIRWTVV-TSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGIT 1636
            ||.|...||.. .:.:|      ::.|..|...|.||:|::...|.||...:..:|:|.|.||.|
Human  1514 RPFGTTVWTTAQRTSLS------KSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGST 1572

  Fly  1637 IPP--PSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSII---TIALTIKHRRTL----- 1691
            |||  .||..:|..|          |:.:....|:.:..|.|.::   .:.|.::.||..     
Human  1573 IPPLIKSVVQNEEGL----------TTNEGLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKR 1627

  Fly  1692 ---CGPIAE---GYESRTLPGDYKEDHENRRNQQVYSA-------SPVKTVDK-----------G 1732
               ...:||   ...:||.....|:....|.:..:..|       ..::|:|.           |
Human  1628 LRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFG 1692

  Fly  1733 NESEM----------YEISPYAT---FSVNGGRTGAPAKTPTRAVAAQTPLD-YTMQFKTFGHPE 1783
            ..::.          |:....||   ..|:..|.|....|...|.|..|..: |..|: |...|.
Human  1693 EAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQW-TLNRPH 1756

  Fly  1784 ---GENLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTEDE------STLSKSMTIVAGSQA-GHS 1838
               ..:...|.:.|......|.|..:|..:........|.      ||.|.|.|....::| .|:
Human  1757 PTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHA 1821

  Fly  1839 KKSNGGRSAK--------SSAACSGVVAGSESDTSISPSTEFSNMPTYRVPCKSSRSSDGRAVVD 1895
            |.....|.||        |..:...:.||:...|....|:..|.....|......:..||..|::
Human  1822 KMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVMN 1886

  Fly  1896 MFRPDSSTESNNDQGSPAPERRHNTPRHVLGMGMAMGLGG-GGGGGVGGGNG------------- 1946
            |..|.:....         :..|..|  .|.|...:..|| |....:..|..             
Human  1887 MAVPKAHRPG---------DLIHLPP--YLRMDFLLNRGGPGTSRDLSLGQACLEPQKSRTLKRP 1940

  Fly  1947 ------PAEKRSAGQRSR-----KHGSAAQQPSNQTLERRKCPGSSNSLDSEVDA 1990
                  |.|..|:...:|     :.|:.|..|..:..|..:....|:|.:|.:|:
Human  1941 TVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELGQAAKMSSSQESLLDS 1995

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 29/76 (38%)
Ig 56..125 CDD:143165 27/68 (40%)
I-set 246..337 CDD:254352 27/94 (29%)
Ig 264..334 CDD:143165 22/69 (32%)
I-set 345..433 CDD:254352 23/88 (26%)
Ig 358..431 CDD:143165 20/73 (27%)
Ig 456..533 CDD:143165 31/76 (41%)
IGc2 553..619 CDD:197706 23/65 (35%)
I-set 634..724 CDD:254352 39/89 (44%)
ig 645..712 CDD:278476 28/66 (42%)
IG_like 734..815 CDD:214653 31/87 (36%)
Ig 745..815 CDD:299845 28/76 (37%)
I-set 820..913 CDD:254352 24/92 (26%)
Ig 838..920 CDD:299845 29/81 (36%)
FN3 917..1033 CDD:238020 34/116 (29%)
FN3 1040..1142 CDD:238020 29/104 (28%)
fn3 1150..1237 CDD:278470 34/94 (36%)
FN3 1263..1345 CDD:238020 27/86 (31%)
Ig 1350..1436 CDD:299845 33/89 (37%)
IG_like 1358..1436 CDD:214653 28/81 (35%)
FN3 1441..1530 CDD:238020 29/89 (33%)
FN3 1542..1620 CDD:238020 29/79 (37%)
DSCAMNP_001380.2 Ig 45..113 CDD:319273 26/67 (39%)
I-set 235..310 CDD:254352 25/79 (32%)
I-set 315..385 CDD:333254 17/75 (23%)
Ig_3 407..488 CDD:316449 33/83 (40%)
IGc2 518..575 CDD:197706 20/58 (34%)
I-set 596..686 CDD:333254 40/90 (44%)
Ig_DSCAM 707..784 CDD:143211 28/76 (37%)
Ig 802..889 CDD:325142 29/87 (33%)
FN3 885..978 CDD:238020 34/116 (29%)
FN3 986..1083 CDD:238020 29/104 (28%)
FN3 1091..1184 CDD:238020 36/101 (36%)
FN3 1189..1278 CDD:238020 35/98 (36%)
Ig 1303..1369 CDD:319273 24/65 (37%)
FN3 1380..1470 CDD:238020 29/89 (33%)
FN3 1486..1555 CDD:238020 25/74 (34%)
Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250|UniProtKB:Q9ERC8 1617..2012 75/391 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1718..1810 21/92 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1855..1883 6/27 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1971..2012 6/25 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 137 1.000 Domainoid score I4888
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47134
OrthoDB 1 1.010 - - D10185at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8541
orthoMCL 1 0.900 - - OOG6_101656
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.690

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