DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and him-4

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_001024582.1 Gene:him-4 / 181187 WormBaseID:WBGene00001863 Length:5198 Species:Caenorhabditis elegans


Alignment Length:2446 Identity:489/2446 - (19%)
Similarity:785/2446 - (32%) Gaps:818/2446 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 PTFLLEPAPRLLFGNDTGAQ-----VTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHF 97
            ||.::....:    |.|..:     ::|.|.|.|.|.:|| .:||. |..:..:..|..||.|:.
 Worm  2287 PTIIMLDKDK----NKTAVEHSTVTLSCPATGKPEPDITW-FKDGE-AIHIENIADIIPNGELNG 2345

  Fly    98 PPFLAQYYRTDVHE---ATYRCRASNEAGTV-LSRNVQVHAVVRRQFHVHVENTEVYLGNSALIK 158
                .|...|.:.|   ..|.|.|.|.||:| ...||.|..:.:.:......:.|.......:|.
 Worm  2346 ----NQLKITRIKEGDAGKYTCEADNSAGSVEQDVNVNVITIPKIEKDGIPSDYESQQNERVVIS 2406

  Fly   159 CAIPEYVRPYVRVASWHRGEEILLPDLSDVAGRYVVLAASGD-LYVRSVRSEDGLMKFSCLVTNT 222
            |  |.|.||..:: :|.:..:.|..|      ::|..:|:|. ||:..:|..|. .|::|:.||.
 Worm  2407 C--PVYARPPAKI-TWLKAGKPLQSD------KFVKTSANGQKLYLFKLRETDS-SKYTCIATNE 2461

  Fly   223 LNGERQRSDAVMLQVKELSKNLAPRTTQKP--VMEIHVERGNDVHLPCNIQGNPFPIFTWYRVSD 285
            ...:::.....||        :|| :..:|  |..|.|..||...|.|..:|:|.|..||  :.|
 Worm  2462 AGTDKRDFKVSML--------VAP-SFDEPNIVRRITVNSGNPSTLHCPAKGSPSPTITW--LKD 2515

  Fly   286 SAALYPIPSSQRVIL--SRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQ 348
            ..|:.|   :.|.:.  :...|.|...:..|.|::.|.|:|..|...:|..|.|       |:|.
 Worm  2516 GNAIEP---NDRYVFFDAGRQLQISKTEGSDQGRYTCIATNSVGSDDLENTLEV-------IIPP 2570

  Fly   349 V--------------------------------------------------QIVNSGGTANF--- 360
            |                                                  ||.:||...:|   
 Worm  2571 VIDGERREAVAVIEGFSSELFCDSNSTGVDVEWQKDGLTINQDTLRGDSFIQIPSSGKKMSFLSA 2635

  Fly   361 -----------------------------------------------------NCTTTGSAIDAI 372
                                                                 ||..:||....:
 Worm  2636 RKSDSGRYTCIVRNPAGEARKLFDFAVNDPPSISDELSSANIQTIVPYYPVEINCVVSGSPHPKV 2700

  Fly   373 DWLHNGKPLQANNA---LTTGRDNIRFL------------------------------------- 397
            .||.:.|||:.::|   ||...:.::.:                                     
 Worm  2701 YWLFDDKPLEPDSAAYELTNNGETLKIVRSQVEHAGTYTCEAQNNVGKARKDFLVRVTAPPHFEK 2765

  Fly   398 ------------------------------------------------SKSSLLVQNVGRRDRGV 414
                                                            ::.:|.|.|:...|.|.
 Worm  2766 EREEVVARVGDTMLLTCNAESSVPLSSVYWHAHDESVQNGVITSKYAANEKTLNVTNIQLDDEGF 2830

  Fly   415 YQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRP---GPLISLKCSASGSPPPQFAWLLDS 476
            |.|...|:....:...:|    .|.|..|...:|.:.|   |..::|.|||:|:|||...::.|.
 Worm  2831 YYCTAVNEAGITKKFFKL----IVIETPYFLDQQKLYPIILGKRLTLDCSATGTPPPTILFMKDG 2891

  Fly   477 Q---------------------------------------------------------------- 477
            :                                                                
 Worm  2892 KRLNESDEVDIIGSTLVIDNPQKEVEGRYTCIAENKAGRSEKDMMVEVLLPPKLSKEWINVEVQA 2956

  Fly   478 --------PIMDVSLHHRFAIGQF-----VDM---SGDVISHLNISHVRPDDGGLYKCVASNSMG 526
                    ||.|.|..|.....||     :||   |....|.|.|....|:|...|.|:|.|..|
 Worm  2957 GDPLTLECPIEDTSGVHITWSRQFGKDGQLDMRAQSSSDKSKLYIMQATPEDADSYSCIAVNDAG 3021

  Fly   527 SVQHSARLNVYGPPYV--RAIGPIKAVAGEDIIVHCPFAGYPVEQIRW---EKAHQEL--TTSNH 584
            ..:...::.|..||.:  .:....:.||...:.:.|...|.|..:|.|   .|...|:  .|...
 Worm  3022 GAEAVFQVTVNTPPKIFGDSFSTTEIVADTTLEIPCRTEGIPPPEISWFLDGKPILEMPGVTYKQ 3086

  Fly   585 YELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGG 649
            .:|:       |.|.|::|.: :|.|||:..::|| .|.:|..:.::.||.:........:.||.
 Worm  3087 GDLS-------LRIDNIKPNQ-EGRYTCVAENKAG-RAEQDTYVEISEPPRVVMASEVMRVVEGR 3142

  Fly   650 RAQITCAVSSGDMPIYFSWKKDDSSIPSS-LQITEKKEEFYSLLVFKDISARHSGKYTCYASNAA 713
            :..|.|.|.....|: .:|.||.....|. ||.:.|    .|.|..::.:....|.|||.|:|.|
 Worm  3143 QTTIRCEVFGNPEPV-VNWLKDGEPYTSDLLQFSTK----LSYLHLRETTLADGGTYTCIATNKA 3202

  Fly   714 AKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKP-LSM 777
            .:...|.:::|.|.||...|........|||..::|:..|.|:|.:|| |..||..:.|.| |.:
 Worm  3203 GESQTTTDVEVLVPPRIEDEERVLQGKEGNTYMVHCQVTGRPVPYVTW-KRNGKEIEQFNPVLHI 3266

  Fly   778 RNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHA 842
            ||       ||..|||.|.|.|:||.|..:...: |:|.....||......:....:...::|..
 Worm  3267 RN-------ATRADEGKYSCIASNEAGTAVADFL-IDVFTKPTFETHETTFNIVEGESAKIECKI 3323

  Fly   843 KGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQ 907
            .|....||.|.:.....:::|...|      .:|  ..|.|..:.|.|.|:|.|:|.|.||.:||
 Worm  3324 DGHPKPTISWLKGGRPFNMDNIILS------PRG--DTLMILKAQRFDGGLYTCVATNSYGDSEQ 3380

  Fly   908 IIFLAVQERP-------DTPSHLEIFEV-------GSRTVKLSWRRPFDG--------------- 943
            ...:.|..:|       .||..:...|:       |:.|..::|:|..|.               
 Worm  3381 DFKVNVYTKPYIDETIDQTPKAVAGGEIILKCPVLGNPTPTVTWKRGDDAVPNDSRHTIVNNYDL 3445

  Fly   944 --NSPVLSYLVQYQALKY-----LQSHGSLAAAGGDW----NGHVINV---------------SL 982
              ||.......||..:..     |.:|.:....|...    .|::..|               .|
 Worm  3446 KINSVTTEDAGQYSCIAVNEAGNLTTHYAAEVIGKPTFVRKGGNLYEVIENDTITMDCGVTSRPL 3510

  Fly   983 PSTSISRS------YDSDLRESAIVAGLTPATTFLIRMQAINEIERS---AYTEAIVLKTQEEAP 1038
            ||.|..|.      ||   |.|     ::|..:.:    .||:.:.|   .|    :.:...||.
 Worm  3511 PSISWFRGDKPVYLYD---RYS-----ISPDGSHI----TINKAKLSDGGKY----ICRASNEAG 3559

  Fly  1039 TEAPSNVQVQTGGESELIVTWQIPPRES-------------------------------WNGELI 1072
            |           .:.:||:...:||:..                               |...  
 Worm  3560 T-----------SDIDLILKILVPPKIDKSNIIGNPLAIVARTIYLECPISGIPQPDVIWTKN-- 3611

  Fly  1073 GYTVNCSEEK----QNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGP 1133
            |..:|.::.:    ||.....:.|..:..   .|..|..||.||.:....:::.:.:...|.   
 Worm  3612 GMDINMTDSRVILAQNNETFGIENVQVTD---QGRYTCTATNRGGKASHDFSLDVLSPPEFD--- 3670

  Fly  1134 WSAAIFGTTAEGVPEAAPQNVNCTA-----LSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQ 1193
                |.||......|.....:.|..     ::.|.:.:||.:......|.:.....|        
 Worm  3671 ----IHGTQPTIKREGDTITLTCPIKLAEDIADQVMDVSWTKDSRALDGDLTDNVDI-------- 3723

  Fly  1194 IDFPAKLEIKRTSNLETYLHT---LHKASNYSIR----------------------------VLA 1227
            .|...||.|.:.|.....|:|   |::|...|:.                            ::.
 Worm  3724 SDDGRKLTISQASLENAGLYTCIALNRAGEASLEFKVEILSPPVIDISRNDVQPQVAVNQPTIMR 3788

  Fly  1228 YTATGDGLASHPL----------------------------FCQTDDD-------VPDAPAAIKA 1257
            ...||     ||.                            ..:||.|       |.:..|.:|.
 Worm  3789 CAVTG-----HPFPSIKWLKNGKEVTDDENIRIVEQGQVLQILRTDSDHAGKWSCVAENDAGVKE 3848

  Fly  1258 AALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYP---------VTFES 1313
            ..:..|......::.|:.|.|.:           .|:..|.......|.||         :.|:|
 Worm  3849 LEMVLDVFTPPVVSVKSDNPIKA-----------LGETITLFCNASGNPYPQLKWAKGGSLIFDS 3902

  Fly  1314 RS---------------LAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFG--QVVR 1361
            ..               |.:..:.::...|..:.|    ||..:.:.:...|..|...|  ...|
 Worm  3903 PDGARISLKGARLDIPHLKKTDVGDYTCQALNAAG----TSEASVSVDVLVPPEINRDGIDMSPR 3963

  Fly  1362 KAVGTGLVLECLAVGNPTPRARWLTRDRPVTFS-PFYEVTNEGN-LKIHRVEGSLSGNYTCTANN 1424
            ......|.|:|||.|.|.|:.||......:|.| |...|.::.. ::|:.|..|..|.|||.|.|
 Worm  3964 LPAQQSLTLQCLAQGKPVPQMRWTLNGTALTHSTPGITVASDSTFIQINNVSLSDKGVYTCYAEN 4028

  Fly  1425 LFGSDEIQYQVIAMKPP-----SAPQIIV-QYASADSI-------RVSW----DAPDDGGAPLQG 1472
            :.|||.:.|.|..::.|     ...|:|. :.|..:.:       :|||    :..:.|   :||
 Worm  4029 VAGSDNLMYNVDVVQAPVISNGGTKQVIEGELAVIECLVEGYPAPQVSWLRNGNRVETG---VQG 4090

  Fly  1473 YTISYHTAGESWSITELLPENNAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQA 1537
              :.|.|.|...:|.|         ...|..|   |...||.|..||...:..:.|....|    
 Worm  4091 --VRYVTDGRMLTIIE---------ARSLDSG---IYLCSATNEAGSAQQAYTLEVLVSPK---- 4137

  Fly  1538 PNANELIATNATCVNLKLSSWQNGGCSIHHFSIEHRPLGDIRWTVVTSDISNAE----------- 1591
                 :|.:....:.....|..:..|::..:     |...|.||:..:||.:.|           
 Worm  4138 -----IITSTPGVLTPSSGSKFSLPCAVRGY-----PDPIISWTLNGNDIKDGENGHTIGADGTL 4192

  Fly  1592 -----ENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGITIPPPSVFPSENDLMN 1651
                 |.|..:..|            :|.||||..|..:...       ||..|.:..|.|..:|
 Worm  4193 HIEKAEERHLIYEC------------TAKNDAGADTLEFPVQ-------TIVAPKISTSGNRYIN 4238

  Fly  1652 NLINSTNPTSGDWFATLIVVVIITVSIITIALTIKHRRTLCGPIAEGYESRTLPGDYKEDHENRR 1716
            .                                           :||.|:     ..|.:.|:..
 Worm  4239 G-------------------------------------------SEGTET-----VIKCEIESES 4255

  Fly  1717 NQQVYSASPVKTVDKGN--ESEMYE-ISPYATFSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKT 1778
            ::..:|.:.|..:...|  .||.|: |...:|...:.|.....|.........:|.|:..:..|.
 Worm  4256 SEFSWSKNGVPLLPSNNLIFSEDYKLIKILSTRLSDQGEYSCTAANKAGNATQKTNLNVGVAPKI 4320

  Fly  1779 FGHPEGENLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTE---DESTLSKSMTI----VAGSQAG 1836
            ...|..:.::......|.....|..:...:|:|.....|.   ||:..:|..::    ::.||||
 Worm  4321 MERPRTQVVHKGDQVTLWCEASGVPQPAITWYKDNELLTNTGVDETATTKKKSVIFSSISPSQAG 4385

  Fly  1837 -HSKKSNGGRSAKSSAACSGVVAGSESDTSISPSTEFSNMPTYRVPCKSSRSSDGRAVVDMFRPD 1900
             ::.|:...            ||.:|.|..:     ...:|...||.:.:.|::.|..|.:    
 Worm  4386 VYTCKAENW------------VASTEEDIDL-----IVMIPPEVVPERMNVSTNPRQTVFL---- 4429

  Fly  1901 SSTESNNDQGSPAP----------ERRHNTPRHVLGMGMAM 1931
                |.|..|.|.|          ..::|....:||..:|:
 Worm  4430 ----SCNATGIPEPVISWMRDSNIAIQNNEKYQILGTTLAI 4466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 26/85 (31%)
Ig 56..125 CDD:143165 23/76 (30%)
I-set 246..337 CDD:254352 28/94 (30%)
Ig 264..334 CDD:143165 20/71 (28%)
I-set 345..433 CDD:254352 28/281 (10%)
Ig 358..431 CDD:143165 21/216 (10%)
Ig 456..533 CDD:143165 29/156 (19%)
IGc2 553..619 CDD:197706 17/70 (24%)
I-set 634..724 CDD:254352 24/90 (27%)
ig 645..712 CDD:278476 20/67 (30%)
IG_like 734..815 CDD:214653 29/81 (36%)
Ig 745..815 CDD:299845 26/70 (37%)
I-set 820..913 CDD:254352 23/92 (25%)
Ig 838..920 CDD:299845 23/88 (26%)
FN3 917..1033 CDD:238020 32/179 (18%)
FN3 1040..1142 CDD:238020 19/136 (14%)
fn3 1150..1237 CDD:278470 18/122 (15%)
FN3 1263..1345 CDD:238020 16/105 (15%)
Ig 1350..1436 CDD:299845 31/89 (35%)
IG_like 1358..1436 CDD:214653 28/79 (35%)
FN3 1441..1530 CDD:238020 24/105 (23%)
FN3 1542..1620 CDD:238020 17/93 (18%)
him-4NP_001024582.1 IG_like 442..515 CDD:214653
IG 527..605 CDD:214652
Ig 628..694 CDD:319273
I-set 702..789 CDD:369462
I-set 793..881 CDD:369462
Ig 899..974 CDD:386229
I-set 1012..1081 CDD:369462
Ig 1109..1172 CDD:319273
Ig 1196..1263 CDD:319273
IG_like 1277..1358 CDD:214653
I-set 1373..1450 CDD:369462
Ig 1474..1544 CDD:386229
IGc2 1563..1628 CDD:197706
Ig 1651..1732 CDD:386229
Ig 1755..1818 CDD:319273
Ig 1839..1912 CDD:386229
Ig 1930..2002 CDD:386229
IG_like 2014..2095 CDD:214653
Ig 2094..2182 CDD:386229
Ig 2190..2283 CDD:386229
I-set 2296..2380 CDD:369462 28/93 (30%)
Ig 2384..2471 CDD:386229 21/96 (22%)
IGc2 2492..2556 CDD:197706 20/68 (29%)
Ig 2580..2654 CDD:386229 5/73 (7%)
Ig 2686..2753 CDD:319273 12/66 (18%)
IG_like 2768..2850 CDD:214653 9/85 (11%)
I-set 2854..2939 CDD:369462 13/84 (15%)
IG_like 2951..3031 CDD:214653 20/79 (25%)
I-set 3046..3116 CDD:369462 21/78 (27%)
I-set 3127..3213 CDD:369462 24/90 (27%)
Ig 3217..3292 CDD:386229 31/82 (38%)
I-set 3300..3386 CDD:369462 23/93 (25%)
I-set 3396..3472 CDD:369462 13/75 (17%)
I-set 3481..3569 CDD:369462 21/114 (18%)
I-set 3591..3663 CDD:369462 12/76 (16%)
Ig 3667..3762 CDD:386229 21/109 (19%)
Ig 3775..3848 CDD:386229 9/77 (12%)
Ig 3859..3947 CDD:386229 15/102 (15%)
IGc2 3968..4031 CDD:197706 23/62 (37%)
Ig_3 4045..4119 CDD:372822 20/90 (22%)
Ig_3 4136..4210 CDD:372822 15/99 (15%)
Ig <4262..4314 CDD:386229 11/51 (22%)
Ig 4318..4406 CDD:386229 19/104 (18%)
IG_like 4418..4496 CDD:214653 12/57 (21%)
I-set 4570..4654 CDD:369462
I-set 4752..4836 CDD:369462
EGF_CA 4996..5027 CDD:238011
EGF_CA 5034..5076 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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