DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and ncam-1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_741709.1	Gene:	ncam-1 / 180418	WormBaseID:	WBGene00017184	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	960	Identity:	207/960 - (21%)
Similarity:	338/960 - (35%)	Gaps:	237/960 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 WYRVSDSAALYPIPSSQRVILSRTL---LLIKNADERDAGKWICQASNQFGEQRIEIRLS----- 336
            |||   ...|.|...|...| .||.   |:|......|.||:.|:...|..:|.:...:|
Worm    87 WYR---DGKLIPRFGSTMTI-ERTYSNQLMINRPKISDGGKYTCKTEIQGEQQEVSAEISFVDPP 147

  Fly   337 --VNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSK 399
              :|...|.|  |:     .|..|...|...|:....:.|..||..|.     .|.:....|...
Worm   148 KFLNVQESQH--PE-----EGTRAEIVCEVEGTDQLEVFWQFNGVTLD-----ETSQRGYEFSEN 200

  Fly   400 SSLLV--QNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVR--PGPLISLKC 460
            :.:|.  ....::|.|:|.|... |.:|.:.::....|...|.:....:....|  .|..|.|||
Worm   201 NQILYIPHFTAKKDDGIYNCNAA-QYSSFETLSVNVTGYARPTITVFDVPNGNRGIEGHTIELKC 264

  Fly   461 SASGSPPPQFAWLL--DSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASN 523
            .|.|.|.|.:.|..  |..||.....|:       |:....:|..||     .:|.|.|||||:|
Worm   265 GAVGKPKPTYKWFFEDDEVPIARSDKHN-------VEEGLLIIESLN-----SEDAGTYKCVANN 317

  Fly   524 SMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELA 588
            ::||.:.:..|.|:..|.|..........|:|:.:.|.:.|......::...|.|....|  |..
Worm   318 TVGSNERTFDLAVFLKPKVDLKHEYVVKEGDDVELVCSYHGEGHVTAKFVSGHSEFAVRN--EAV 380

  Fly   589 SVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQI 653
            |..:..::   ..|....:.:.|   .|...||.....::.:.|...:...:...:.|:.|
Worm   381 SAGNSEEI---RPESNESEEVTT---TSENSEETSTQDEVELKSAENVNDEEDHTSQQDDG---- 435

  Fly   654 TCAVSSGDMPIYFSWKK--DDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKV 716
                ...:......||:  ||   .::.:|:.:.||...:|..|.||...:..|||..||.|..|
Worm   436 ----EQDEQEESKKWKRFADD---VNNQRISVRAEENKLILTIKSISLEDAADYTCAVSNDAGTV 493

  Fly   717 NYTAELQVRVAPRWR-YEPMDTAIMLGNTISINCEAEGYPIPTITWFKG---------------Q 765
            |...::.:...|..| |.........|||:|:.|:....|.|...|||.               |
Worm   494 NKVTQVGIIHPPTLRHYTGPHIRSFDGNTVSVYCDVSAVPSPKWHWFKNGKEVEANGVSIQIFTQ 558

  Fly   766 GKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPA----------- 819
            |..:|    |::.|..     .:|| .|.|.|:|.|.:|...|:...|.|..||
Worm   559 GSSTK----LTLENFD-----GSDN-FGVYTCRADNGVGQLEKQIDVIKVVSPATPSGMNCKKMV 613

  Fly   820 -------RFEQSARNISSRRNDPVTLD---------------CHAKGDEPITIGWTQNNGRIDLN 862
                   .||...  .....:.|.|::               .||   :|:::.:
Worm   614 YPNYGKCSFESDI--YEKEESKPQTMELLVAKLEEMESDYNWSHA---QPVSVPF---------- 663

  Fly   863 NFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQE----RPDTPSHL 923
                           :..|||.:...:...|.:..|.|..|.:|....::::.    .|..|
Worm   664 ---------------EDDLTIPNLTSNTQYVIKARAVNEAGSSEYSEEISLETTDPWAPQAP--- 710

  Fly   924 EIFEVGSRTVK------LSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSL 982
                 ||..:|      :||..|.|..||:|.:.|..|.:||......:.....:.:    |.:.
Worm   711 -----GSVAMKCSDYCTVSWDTPNDHGSPLLKFKVTIQEMKYKTDDDEVEEKSDEKS----NNNS 766

  Fly   983 PSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEA---PTEAPSN 1044
            ..|..:.|.|:|..|::              .::| ||:.::..:...|..::.|   ||:..::
Worm   767 EETETTTSDDNDETEAS--------------NESI-EIKENSEEQETTLAHEDSAEILPTDPSTS 816

  Fly  1045 VQVQTGGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKAT 1109
            |      |.:.:|.:         |.|:...|: |||.|                        ..
Worm   817 V------ERDEMVPY---------GSLLVLNVD-SEENQ------------------------VQ 841

  Fly  1110 LRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTAL 1159
            |..::::|.|.:::.|.|..|.|..:...|.|  :..|....:.::.|.|
Worm   842 LTNIKQHSYYKISVAAENEKGQGEPAEIDFQT--DDSPTKYEEGIDSTHL 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	18/66 (27%)
		Ig	264..334	CDD:143165	17/56 (30%)
		I-set	345..433	CDD:254352	18/89 (20%)
		Ig	358..431	CDD:143165	16/74 (22%)
		Ig	456..533	CDD:143165	27/78 (35%)
		IGc2	553..619	CDD:197706	12/65 (18%)
		I-set	634..724	CDD:254352	21/91 (23%)
		ig	645..712	CDD:278476	17/68 (25%)
		IG_like	734..815	CDD:214653	25/95 (26%)
		Ig	745..815	CDD:299845	22/84 (26%)
		I-set	820..913	CDD:254352	15/107 (14%)
		Ig	838..920	CDD:299845	12/100 (12%)
		FN3	917..1033	CDD:238020	26/121 (21%)
		FN3	1040..1142	CDD:238020	18/101 (18%)
		fn3	1150..1237	CDD:278470	2/10 (20%)
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
ncam-1	NP_741709.1	IG	64..142	CDD:214652	17/58 (29%)
		Ig	69..140	CDD:143165	17/56 (30%)
		IG_like	153..236	CDD:214653	20/95 (21%)
		Ig	160..222	CDD:299845	15/66 (23%)
		IG_like	256..330	CDD:214653	29/85 (34%)
		IGc2	256..320	CDD:197706	26/75 (35%)
		IG_like	<445..499	CDD:214653	19/56 (34%)
		Ig	<445..498	CDD:143165	19/55 (35%)
		IG_like	520..596	CDD:214653	24/85 (28%)
		IGc2	520..587	CDD:197706	22/76 (29%)
		FN3	<652..701	CDD:238020	11/76 (14%)
		FN3	<817..873	CDD:238020	18/95 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910