DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and Ncam2

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	708	Identity:	172/708 - (24%)
Similarity:	291/708 - (41%)	Gaps:	113/708 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 CSASGSPP------PQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYK 518
            |:|.|.|.      ||...::.:|.:|             :...| |.|.|.|.:...:|.|:|:
Mouse    42 CTAIGEPESIDWYNPQGEKIISTQRVM-------------LQKEG-VRSRLTIYNANIEDAGIYR 92

  Fly   519 CVASNSMGSVQH-SARLNVYGP-PYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTT 581
            |.|:::.|..|. :..|.:|.. .:...:.|.:...|||..|.|..:..|...:.|...::|:||
Mouse    93 CQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTT 157

  Fly   582 SNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRA-GEEARRDMQLNVNSPP-VIEPFK-FPK 643
            ......|.:|: ..|.|.|:... |:|||.|..|..| ||...||:.:.||.|| ::.|.| |..
Mouse   158 IPDNRFAVLAN-NNLQILNINKS-DEGIYRCEGRVEARGEIDFRDIIVIVNVPPAIMMPQKSFNA 220

  Fly   644 NLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFY-----SLLVFKDISARHSG 703
            ..:.|....:||..|....|. .||.::.       ::.|:.|::.     :.|..::|..:..|
Mouse   221 TAERGEEMTLTCKASGSPDPT-ISWFRNG-------KLIEENEKYILKGSNTELTVRNIINKDGG 277

  Fly   704 KYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFK----- 763
            .|.|.|:|.|.:....|.|||.|.|.......:|....|: :::.|||||.|:|.|||.:
Mouse   278 SYVCKATNKAGEDQKQAFLQVFVQPHILQLKNETTSENGH-VTLVCEAEGEPVPEITWKRAIDGV 341

  Fly   764 --GQGKGSKDFKPLSMRNH---SLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQ 823
              .:|..|.|.:......|   ||.:.....:|.|.|.|:|.:.|| |.::::.:::....:|..
Mouse   342 MFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIG-GHQRSMHLDIEYAPKFVS 405

  Fly   824 SARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEK-GVDSQLTIGHSD 887
            :.....|...:|:.:.|....:.|.:|.|.:....:...|    ...:||.. |....|.|..:.
Mouse   406 NQTMYYSWEGNPINISCDVTANPPASIHWRREKLLLPAKN----TTHLKTHSVGRKMILEIAPTS 466

  Fly   888 RHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRP-FDGNSPVLSYL 951
            .:|.|.|.|.|.|..|...|...|.:.:.|.:|..::|.|:...|.|:|:.:| ..|..|:..|.
Mouse   467 DNDFGRYNCTATNRIGTRFQEYILELADVPSSPHGVKIIELSQTTAKISFNKPESHGGVPIHHYQ 531

  Fly   952 VQYQAL-----KYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFL 1011
            |..:.:     |.::|||                              ::...:::.|.|.||:.
Mouse   532 VDVKEVASETWKIVRSHG------------------------------VQTMVVLSSLEPNTTYE 566

  Fly  1012 IRMQAINEIERSAYTEAIVLKTQEEAPTEAPS----NVQVQTGGESELIVTWQIPPRESWNGELI 1072
            ||:.|:|...:..|::..:.:|   .|...||    :.|..:|...::.:|.|    :.....::
Mouse   567 IRVAAVNGKGQGDYSKIEIFQT---LPVREPSPPSIHGQPSSGKSFKISITKQ----DDGGAPIL 624

  Fly  1073 GYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFG 1130
            .|.|....:.:...::.......|..|:         |..|:....|.|.|.|.|..|
Mouse   625 EYIVKYRSKDKEDQWLEKKVQGNKDHII---------LEHLQWTMGYEVQITAANRLG 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	20/79 (25%)
		IGc2	553..619	CDD:197706	22/66 (33%)
		I-set	634..724	CDD:254352	23/96 (24%)
		ig	645..712	CDD:278476	15/71 (21%)
		IG_like	734..815	CDD:214653	26/90 (29%)
		Ig	745..815	CDD:299845	24/79 (30%)
		I-set	820..913	CDD:254352	22/93 (24%)
		Ig	838..920	CDD:299845	20/82 (24%)
		FN3	917..1033	CDD:238020	25/121 (21%)
		FN3	1040..1142	CDD:238020	18/95 (19%)
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274	21/83 (25%)
		I-set	22..111	CDD:254352	21/82 (26%)
		I-set	117..193	CDD:254352	22/77 (29%)
		IGc2	128..189	CDD:197706	20/62 (32%)
		Ig	208..301	CDD:299845	26/100 (26%)
		I-set	215..298	CDD:254352	21/90 (23%)
		Ig	300..397	CDD:299845	28/98 (29%)
		IG_like	308..395	CDD:214653	26/88 (30%)
		IG_like	413..491	CDD:214653	19/81 (23%)
		IGc2	414..482	CDD:197706	17/71 (24%)
		FN3	496..588	CDD:238020	25/121 (21%)
		fn3	594..678	CDD:278470	18/93 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900