DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Ncam1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_006510118.1	Gene:	Ncam1 / 17967	MGIID:	97281	Length:	1162	Species:	Mus musculus

Alignment Length:	1071	Identity:	243/1071 - (22%)
Similarity:	378/1071 - (35%)	Gaps:	268/1071 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 DVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNV---YGPPYVRAIGPIKAVAGEDIIVHC 560
            |..|.|.|.:...||.|:||||.:...|: |..|.:||   ....:..|..|.:...|||.::.|
Mouse    76 DDSSTLTIYNANIDDAGIYKCVVTAEDGT-QSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVC 139

  Fly   561 PFAGYPVEQIRWEKAHQE---------LTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRS 616
            .........|.|:...::         :..||:|          |.|:.::. .|:|.|.|..|.
Mouse   140 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNY----------LQIRGIKK-TDEGTYRCEGRI 193

  Fly   617 RA-GEEARRDMQLNVNSPPVIEPFKFPKNLQE--GGRAQITCAVSSGDMPIYFSWKKDDSSIPSS 678
            .| ||...:|:|:.||.||.::..:...|...  |....:.|.......|. .||.||...|.:.
Mouse   194 LARGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPT-MSWTKDGEPIENE 257

  Fly   679 LQITEKK--EEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIML 741
            .:..||.  .:..|.|..:::......:|.|.|.|.|.:.:.:..|:|...|:..|....||:.|
Mouse   258 EEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFAKPKITYVENQTAMEL 322

  Fly   742 GNTISINCEAEGYPIPTITWFKGQGKGSKDFKP--------------LSMRNH----SLLLNLAT 788
            ...:::.|||.|.|||:|||.......|.:.|.              :.:|:|    ||.|....
Mouse   323 EEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQ 387

  Fly   789 DNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWT 853
            ..|.|.|:|.|:|.||.. .:::.:.|....:. |....:.:...:.|.:.|........||.|.
Mouse   388 YTDAGEYICTASNTIGQD-SQSMYLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFAYPSATISWF 450

  Fly   854 QNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQ-ERP 917
            ::...:..:|:. :|....|...  |.|.:.....:|.|.|.|.|.|..|: |.:.|:.|| :.|
Mouse   451 RDGQLLPSSNYS-NIKIYNTPSA--SYLEVTPDSENDFGNYNCTAVNRIGQ-ESLEFILVQADTP 511

  Fly   918 DTPSHLEIFEVGSRTVKLSWRRP-FDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVS 981
            .:|| ::..|..|.|.::.:..| ..|..|:|.|..::::|             |:.:.|.
Mouse   512 SSPS-IDRVEPYSSTAQVQFDEPEATGGVPILKYKAEWKSL-------------GEESWHF---- 558

  Fly   982 LPSTSISRSYD---SDLRESAIVAGLTPATTFLIRMQAIN-----EIERSAYTEAIVLKTQ--EE 1036
                   :.||   :::.....:.||.|.|.:.:|:.|:|     ||  ||.||   .|||  ..
Mouse   559 -------KWYDAKEANMEGIVTIMGLKPETRYSVRLAALNGKGLGEI--SAATE---FKTQPVHS 611

  Fly  1037 APTEAPSNVQVQTGGESELI------VTWQIP--------------PR-ESWNGELIGYTVNCSE 1080
            .|..||:|       .|.|:      .||.:|              |: |...|| .|.::..:.
Mouse   612 PPPLAPAN-------SSTLVPLSPRATTWPLPVLPTTDLSKGEPSAPKLEGQMGE-DGNSIKVNL 668

  Fly  1081 EKQN----------INFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWS 1135
            .||:          :.:.:.:.|..|..|.....:....|:.|...:.|.|.:.|.|..|....:
Mouse   669 IKQDDGGSPIRHYLVKYRAKLASEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAA 733

  Fly  1136 AAIFGTTAEGVPEAAPQNVNCTA-LSSQSLKISWLEPPLQFHGGIIQGYKILY------------ 1187
            ..:|.|:|:  |.|.|.|.:.|| ||:                |.|.|..|:.
Mouse   734 HFVFRTSAQ--PTAIPANGSPTAGLST----------------GAIVGILIVIFVLLLVVMDITC 780

  Fly  1188 ------------------------------------------RPIVHQIDFPAKLEIKRTSNLET 1210
                                                      .|||.     .:.|.:||.|.:.
Mouse   781 YFLNKCGLLMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVE-----VRTEEERTPNHDG 840

  Fly  1211 YLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPKNR 1275
            ..||....:.             .|....|...|...|.|...::......:|:|..::.|.  :
Mouse   841 GKHTEPNETT-------------PLTEPELPADTTATVEDMLPSVTTVTTNSDTITETFATA--Q 890

  Fly  1276 NGIISHYTVYSREAGRKGQAKTHMVRVDENGYP---------VTFESRSLAENQMYEFWVSASTS 1331
            |...|..|..:...     |.......|.|..|         ||..|.|.|........|..|.:
Mouse   891 NSPTSETTTLTSSI-----APPATTVPDSNSVPAGQATPSKGVTASSSSPASAPKVAPLVDLSDT 950

  Fly  1332 VGEGEPTS----------VIAQATNTRAPARIASFGQVVR-----KA------VGTGLVLECLAV 1375
                 |||          |:|......:|:..||.|:..:     ||      ...|......||
Mouse   951 -----PTSAPSASNLSSTVLANQGAVLSPSTPASAGETSKAPPASKASPAPTPTPAGAASPLAAV 1010

  Fly  1376 GNPTPRARWLTRDRPVTFSPFYEVTNEGNLK 1406
            ..|...|....::.|.|..|..|.|..|.:|
Mouse  1011 AAPATDAPQAKQEAPSTKGPDPEPTQPGTVK 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	13/33 (39%)
		IGc2	553..619	CDD:197706	17/75 (23%)
		I-set	634..724	CDD:254352	20/93 (22%)
		ig	645..712	CDD:278476	15/70 (21%)
		IG_like	734..815	CDD:214653	28/98 (29%)
		Ig	745..815	CDD:299845	25/87 (29%)
		I-set	820..913	CDD:254352	20/92 (22%)
		Ig	838..920	CDD:299845	21/82 (26%)
		FN3	917..1033	CDD:238020	29/124 (23%)
		FN3	1040..1142	CDD:238020	26/132 (20%)
		fn3	1150..1237	CDD:278470	20/141 (14%)
		FN3	1263..1345	CDD:238020	22/100 (22%)
		Ig	1350..1436	CDD:299845	18/68 (26%)
		IG_like	1358..1436	CDD:214653	14/60 (23%)
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Ncam1	XP_006510118.1	Ig1_NCAM-1	20..115	CDD:143273	16/39 (41%)
		IG	124..190	CDD:214652	15/76 (20%)
		Ig3_NCAM-1_like	211..308	CDD:143207	22/97 (23%)
		Ig_NCAM-1	307..413	CDD:143277	30/106 (28%)
		Ig_3	417..494	CDD:372822	16/80 (20%)
		FN3	509..606	CDD:238020	29/126 (23%)
		fn3	649..731	CDD:365830	17/82 (21%)
		PHA03247	<905..1140	CDD:223021	34/142 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900