DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and lad-2

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001023496.1	Gene:	lad-2 / 177078	WormBaseID:	WBGene00002243	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	1435	Identity:	295/1435 - (20%)
Similarity:	499/1435 - (34%)	Gaps:	427/1435 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 TWVLRDGS---LATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEATYRCRASNEAGTVLSRNVQV 132
            :| |:||.   :.::.....|.|.:|::.|....|.      |:..|:|.|||..||.||..:.:
Worm    63 SW-LKDGEPFVIDSEDVLWEKESQSGSIVFTKPHAS------HQGYYQCFASNIFGTALSNKMHL 120

  Fly   133 HAVVRRQFHVH-VENTEVYLGNSALIKCAIPEYVRPYVRVASWHRGEEILLPD---LSDVAGRYV 193
            .......|... |:...|..|.|..:.|..|... |..::...:|.    |.|   :..:..|::
Worm   121 RLGSLEHFPKRDVKLLRVKEGESLTLNCTPPRGT-PDPKIVWLYRS----LDDSSVIETIRSRHI 180

  Fly   194 VLAASGDLYVRSVRSEDG--LMKFSCLVTN-TLNGERQRSDAVMLQVKELSKNLAP--RTTQKPV 253
            .:...|.|:..||...||  .:.:.|..|: .|.||.:..|.:.|.::.......|  :.:..|
Worm   181 TVDNEGHLHFSSVELSDGKATLVYECAATSPVLRGEYRSGDRIQLDIEPSQDKSHPVKKMSVSP- 244

  Fly   254 MEIHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKN--ADERDAG 316
            .|:.|..|..:.|.|...|.|.|...|.::...     :|.|:          ||:  :.|.|.|
Worm   245 SEVTVRAGGQLKLQCIFGGRPLPTIFWSKIDGE-----LPKSR----------IKDLTSHESDFG 294

  Fly   317 KWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPL 381
            :
Worm   295 R---------------------------------------------------------------- 295

  Fly   382 QANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQC----LVE--NQRASAQAMAELKLGDTVPE 440
                               ||:|:||...|.|.|:|    ||.  |.|..|....|..     |.
Worm   296 -------------------SLIVENVHPDDAGAYECRGRHLVHTVNVRVMAAPFWEFD-----PP 336

  Fly   441 LIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLN 505
            ...:..|::..     .|:|.|.|.|.|...|.::.:.:.:::...|..:   :| .|.::...|
Worm   337 RDISLPEESTG-----ELECLAGGQPTPIITWSMNGKFLHELAEDSRRVL---LD-HGRILRVRN 392

  Fly   506 ISHVRPD-DGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPI---------KAVAGEDIIVHC 560
            ::|   | |.|:|:|.|||.:|.|..:|.:      :|||..|.         |.|....:::.|
Worm   393 LNH---DLDTGVYQCNASNPLGYVFANAFV------HVRAHAPFFRMPAARHWKVVLHSTVVLDC 448

  Fly   561 PFAGYPVEQIRWEKAH---------QELTTSNH----YELASVADGGQLVIKNVEPGRDQGIYTC 612
            .....|...:||..|.         :.....||    |::.|.               |:|:|.|
Worm   449 DVDAAPEAMVRWVDADDRPLQVVEGKNKLFPNHTFMVYDVNSA---------------DEGLYYC 498

  Fly   613 IVRSRAGEEARRDMQLNVNSPPVIEPFKFPKN--LQEGGRAQITC-AVSSGDMPIYFSWKKDDSS 674
            .|.::.|.. |...:|.|..|........||.  |:.|..|::.| ||:...:||.:.|..:...
Worm   499 NVSNKYGIN-RATNRLQVFKPTYFVRIPTPKRLILEAGETAEVFCEAVADPRLPIRYQWTINGKV 562

  Fly   675 IPSSLQITEKKEEFYSLLV----FKDISARHSGKYTCYA-SNAAAKVNYTAELQVRVAPRWRYEP 734
            :..|        ::|.:|.    |:.:..||||...|.| ::...|:   |.:|:.|.....:..
Worm   563 LTES--------QYYEILPDRLRFRSVRGRHSGIIDCAAITDVDVKL---ASMQLIVKDVPAHPV 616

  Fly   735 MDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQA 799
            ::||         :|....   .|:.|.                                    |
Worm   617 VETA---------HCSERK---ATVKWV------------------------------------A 633

  Fly   800 TNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNF 864
            .::.|..:||.|                        |.:....|.:|     |...|..:::|..
Worm   634 ASDHGDSIKKYI------------------------VEMFTDFKKNE-----WEVINEEVNVNKE 669

  Fly   865 RFSIAEMKTEKGVDSQLT--IGHSDRHDSGVYRCIAENPYGRAEQII-------FLAVQERPDTP 920
            .|.         ||..||  :.::       :|.:|.|.:||::..|       :|..|.||..|
Worm   670 TFE---------VDITLTPWVNYT-------FRVVAVNSHGRSDMKIDGQPKEDWLTCQTRPSFP 718

  Fly   921 SHLEIFEVGSRT----VKLSWRRPFD---GNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVI 978
            ........|..|    :.:|| :|.|   .|:|.:.|||:|:..:.:  ||        |...::
Worm   719 YTNPTGVKGEGTEPDNLVISW-KPLDRYYWNAPNMQYLVRYKLDEPI--HG--------WTEFLV 772

  Fly   979 NVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQ-------EE 1036
            ..||.:.:|.|...:..:             :||::|::|.:..|      :::.:       |:
Worm   773 EDSLANFTIIRDQPTFRK-------------YLIQVQSVNSVGPS------IVEPEIHHGWSGED 818

  Fly  1037 APTEAPSNVQVQTG-GESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISV---VNSSLKS 1097
            .|.|||.:..:.|. ..:.:..||......:.||..:||.:...:.:..|...|:   .||:.|
Worm   819 VPDEAPRDFHIDTQINFTTINFTWNPVDANTVNGHFVGYEIEYWKAENTIRKYSIKIPANSTYK- 882

  Fly  1098 TIVSGWATTKATLRGLRKYSRYAVTIRAMNS-FGSGPWSAAIFGTTAEGVPEAAP---QNVNCTA 1158
                       .:......:.|:..||..|. ..|.|.....|     .:||..|   .|:...:
Worm   883 -----------VINSFHAVTNYSAHIRTRNKRLRSAPSDYVSF-----AMPEGPPGKVHNLRVYS 931

  Fly  1159 LSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKAS---- 1219
            :.|.::.:.| :.||| ..|.|:||.|.::        ..|.|.:.|..:....|.||:.|
Worm   932 VGSTAILLQW-DAPLQ-PNGRIRGYFISFQ--------NEKNETEETYVIHRQKHYLHEKSEPDT 986

  Fly  1220 NYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPKNRN-------G 1277
            .|.:.|.|.|..|:|..:..........:|||| ..:...::.||.::.| .|.|.:       .
Worm   987 GYKVSVWAETRAGEGPVTLRPVRTWPARIPDAP-IFRVKNISLDSFVVEW-QPNNHSVWKMPGAA 1049

  Fly  1278 IISHYTVYSREAGRKGQAKTHMVRVDENGYPVT-FESRSLAENQMYEFWVSASTSVGEGEPTSVI 1341
            ...:||..|    .|...::.::.:     |.| ...|:|.|:|.|.....|.......|...:.
Worm  1050 FFVNYTAES----SKTWFQSEIIYL-----PYTEITIRNLKEDQKYFMQGIAKDGPRRSESVFLP 1105

  Fly  1342 AQATNTRAPARI-------ASFGQVVRKAVGTGLVLECL--AVGNPTPRARWLTRDRPVTFSPFY 1397
            .:..|.....|:       |::...|...:|.||...||  ..||...:.::..|.:.:...  :
Worm  1106 IKTLNRDYANRLKEDSLRSAAWFIAVLGVLGIGLFTICLTFCCGNKNRQEKFAVRRKEIEIG--H 1168

  Fly  1398 EVTNE 1402
            :..||
Worm  1169 QQDNE 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	19/64 (30%)
		Ig	56..125	CDD:143165	16/56 (29%)
		I-set	246..337	CDD:254352	18/94 (19%)
		Ig	264..334	CDD:143165	13/71 (18%)
		I-set	345..433	CDD:254352	15/93 (16%)
		Ig	358..431	CDD:143165	14/78 (18%)
		Ig	456..533	CDD:143165	22/77 (29%)
		IGc2	553..619	CDD:197706	14/78 (18%)
		I-set	634..724	CDD:254352	23/97 (24%)
		ig	645..712	CDD:278476	19/72 (26%)
		IG_like	734..815	CDD:214653	10/80 (13%)
		Ig	745..815	CDD:299845	8/69 (12%)
		I-set	820..913	CDD:254352	18/101 (18%)
		Ig	838..920	CDD:299845	20/90 (22%)
		FN3	917..1033	CDD:238020	26/122 (21%)
		FN3	1040..1142	CDD:238020	22/106 (21%)
		fn3	1150..1237	CDD:278470	25/93 (27%)
		FN3	1263..1345	CDD:238020	18/89 (20%)
		Ig	1350..1436	CDD:299845	13/62 (21%)
		IG_like	1358..1436	CDD:214653	11/47 (23%)
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
lad-2	NP_001023496.1	IG_like	48..116	CDD:214653	18/59 (31%)
		Ig	49..121	CDD:299845	19/64 (30%)
		Ig	124..214	CDD:299845	20/94 (21%)
		IG_like	244..325	CDD:214653	29/179 (16%)
		Ig	255..325	CDD:299845	25/167 (15%)
		I-set	335..421	CDD:254352	25/103 (24%)
		Ig4_L1-NrCAM_like	344..422	CDD:143179	23/95 (24%)
		IG_like	438..515	CDD:214653	18/92 (20%)
		Ig	443..516	CDD:299845	17/88 (19%)
		IG_like	527..608	CDD:214653	24/91 (26%)
		Ig	535..>593	CDD:299845	17/65 (26%)
		FN3	610..697	CDD:238020	26/179 (15%)
		FN3	721..804	CDD:238020	23/106 (22%)
		fn3	823..909	CDD:278470	19/97 (20%)
		FN3	921..1010	CDD:238020	25/98 (26%)
		FN3	1016..1108	CDD:238020	22/102 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910