DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and ptp-3

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001263671.1	Gene:	ptp-3 / 174685	WormBaseID:	WBGene00004215	Length:	2248	Species:	Caenorhabditis elegans

Alignment Length:	1843	Identity:	397/1843 - (21%)
Similarity:	652/1843 - (35%)	Gaps:	475/1843 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 NADERDAGKWICQ----ASNQFGEQRIEIRLSVNSY-VSVHILPQVQIVNSGGTANFNCTTTGSA 368
            |.|.:|.|..:.:    .:||...:..:..:...:| ..:.:.|....|......:|.|...|:.
Worm    55 NQDVQDGGIPLVRKEEFTNNQLYAEAYQSYIQALAYPARLVVRPDSSTVVDESKISFFCRADGNP 119

  Fly   369 IDAIDWLHNGKPLQANN-----ALTTGRDNIRFLSKSSLLVQNVGRRDRG-VYQCLVENQRAS-- 425
            :.::.|..|||.:..:|     :|.||...:||        :.|...|.. |..|..:|..|:
Worm   120 LPSVIWRVNGKSITDHNRISIKSLATGLSTLRF--------ERVSLDDNATVVSCSADNGVANPV 176

  Fly   426 -AQAMAELKLGDTVPELIYTFIE-----QNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSL 484
             |:|...:...|.|| :.:..||     ::|..|....:.|...|.|..:..||.|..| :|:..
Worm   177 VAEASLTVVPRDKVP-IGFPQIELHPSLKSVEQGKTAYVSCRVRGDPRAKVLWLRDLIP-LDIRA 239

  Fly   485 HHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVY-----GPPYVR- 543
            ..|:::....:...     |.|.|.|.:|.|.|:|:|.|::| |.||...|:|     .|||..
Worm   240 DGRYSVSTIGNPGA-----LMIQHAREEDQGKYECIARNTLG-VAHSKAANLYVKVRRVPPYFSY 298

  Fly   544 ------AIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVE 602
                  .:|     .|.:|.:.|...|||:.::.|:|.  :|...:....|.:.. ..|.:.:||
Worm   299 KLERQYVVG-----VGGNINLTCVAVGYPMPRVFWKKT--DLMVLDDPSTAPIGK-NVLTLTHVE 355

  Fly   603 PGRDQGIYTCIVRSRAGE-EARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYF 666
            ...:   :||:..|..|. ||...:......||       |.|:       :..:|:|
Worm   356 STEN---FTCVAVSALGNIEATTTVIAKELPPP-------PVNI-------VVSSVTS------- 396

  Fly   667 SWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWR 731
                      .|:.||.|..::...:          .||.         |||          |.:
Worm   397 ----------ESVVITWKPPKYNEAI----------NKYV---------VNY----------RLK 422

  Fly   732 YEPMDTAIMLG--NTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGY 794
            .|..|.|.:..  :......::|.|         .:|:.|:. |.:....:||:::.........
Worm   423 SENKDDAALFAKDSRAEDESDSERY---------SEGRSSRG-KTMETLENSLVIDGLVAFQTYE 477

  Fly   795 YMCQATNEIGAGLKK---TIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGW---T 853
            :..::...:|.||:.   ..:...::||             ..||:....:...:.|.:.|   .
Worm   478 FTVRSAGPVGVGLESLPVEAQTKPSKPA-------------TAPVSPQARSLNRDSILVKWGPCE 529

  Fly   854 QNNGRIDLNNFRFS-------IAEMKTE--KGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQII 909
            |.||.|......::       |.|.|..  |..:...||...:.......|.||:|..|.:....
Worm   530 QPNGLITGYKVYYTNDLVTTPIREWKQHDAKSDEFMTTINGLEPDSRYFVRVIAQNSEGDSPLST 594

  Fly   910 FLAVQER---PDTPSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGG 971
            .:.|..|   |..|..|.:..:.||.::|:|.:|. .:|||:.|.|:|..     |.|..
Worm   595 LVTVATRQGIPGQPPMLTVKALDSRRMQLTWDKPL-YSSPVVGYTVRYNT-----SDGEK----- 648

  Fly   972 DWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEE 1036
                   .::|.|.          .|..:|.||.|...:..|:.|.::..:..:||.::.||...
Worm   649 -------ELTLTSP----------HEKHVVTGLHPDKYYYFRVAAYSDRGQGEFTEPMISKTIAS 696

  Fly  1037 APTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTVNC--SEEKQNINFISVV-------N 1092
            .|..:|:.|.........:.:.|:.|.::..||.|..|.:|.  .|:.:..|..||.       :
Worm   697 IPLSSPTIVSAAATSSKSVEIRWKGPEQKKLNGVLTAYRINYFRLEDSKTANLESVEYDEDMDDS 761

  Fly  1093 SSL--KSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVN 1155
            ||.  :.::|.....|...|..|..||.|.:|:.|....|.||.|:.....|.|.|| :||:|.|
Worm   762 SSFLDRMSVVVPSDATSYVLSDLLPYSSYEITVAASTMDGYGPESSIRVVKTLEDVP-SAPRNFN 825

  Fly  1156 CTALSSQSLKISWLEPPLQFHGGIIQGYKILYR-----PIVHQIDFPAKLEIKRTSNLETYLHTL 1215
            ....|:.|:|::| :.|...:|.::..|..|.|     |:|.:......:.|:.:|.....|.:|
Worm   826 AELTSATSVKLTW-DAPAAANGALLGYYVYLDRMVNGEPVVEKGSKKRIVMIRDSSKRYFELDSL 889

  Fly  1216 HKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADS----ILISWLTPKNR- 1275
            ...:.||.|:.|:...|||..|......|....|:|| .|.:.:|..|.    ..|.|..||.:
Worm   890 DPNTEYSFRLNAFNRNGDGEFSERKSIITQGIPPEAP-EIVSVSLDRDEPPVVARIEWKMPKMKP 953

  Fly  1276 -NGIISHYTVYSREAGRKG---QAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSA-------- 1328
             ...|..|.::.|..|...   :|||    ||......|..  .|....:|:..::|
Worm   954 NETPIEKYNLWLRAQGYPDSYVKAKT----VDGTDLSTTIS--GLWMGVVYDVLLAAENREGRSQ 1012

  Fly  1329 ------STSVG--EGEPTSVIAQ------ATNTRAPARIASFGQVVR-KAVGTGLVLECLAVGNP 1378
                  :|.||  :|||..|..:      ..:.|.|:.....|.:.. ||:.:.:.........|
Worm  1013 NATETIATPVGSPDGEPIDVQYEVMKGKIVVSWRPPSEEKRNGNITSYKAILSAMDATADRYEQP 1077

  Fly  1379 TPRARWLTRDRPVTFSPFYEVTNEGNLKIHRVEGSLS---GNYTCTANNLFGSDEIQYQVIAMKP 1440
            .|        .|.|.|.| || |.....:.:|..:..   |.|:              .|:.:.|
Worm  1078 VP--------APSTSSTF-EV-NVRRAYLFKVAAATMKGIGPYS--------------PVLTINP 1118

  Fly  1441 -PSA-----PQIIVQYASADSIRVSWDAPDDGGAPLQGYTISY-HTAG-----ESWS---ITELL 1490
             |:|     ..:.|:..|..:..|.||....   ....:.:.| |..|     |.|.   :..:.
Worm  1119 DPAALVGPPTNVRVEATSNSTAVVQWDFESQ---KADSFVVKYMHEPGNRMDTEKWKQLPVVSID 1180

  Fly  1491 PEN-NAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLK 1554
            .|| ..|.:         :..::||......|.:.:.|  .:|..|..|...|.:.......||:
Worm  1181 KENPKRFAV---------VSDLNAHKPYAFCVLAVKNN--RQGPCSDPPTVLESVTPTYMVQNLR 1234

  Fly  1555 L---------SSWQNGGCSIHHFSIEHRPLGDI------RWTVVT----SDISNAEENRENLIFC 1600
            :         .:|:..|.....|.:.|....|.      ..|:.|    .|:.  |::||.|
Worm  1235 VLWKTSNSVQLTWEYNGPRNVGFYVNHTGRKDYVNHELQEKTMSTPGFGQDVD--EKHREYL--- 1294

  Fly  1601 DFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGITIPPPS--VFPSENDLMNNLINSTNPTSGD 1663
                  |..||           .|..: |.::...|:||.:  .:|.|      ::..|:|| |.
Worm  1295 ------WTNLR-----------PHMMY-TIHVGVRTLPPGARKYWPQE------VVTITDPT-GP 1334

  Fly  1664 WFATLIVVV----------IITVSIITIALTIKHRRTLCGPIAEGYESRTLPGDYK-EDHEN--- 1714
            .|..:..:|          :|.::..|...         |||:. |....:|.:|. ||..|
Worm  1335 PFVDVPKLVDSSGTQPGQQMIRLTPATEEY---------GPISH-YWIILVPANYSTEDVVNLDP 1389

  Fly  1715 ---------RRNQ--QVYSASPVKTVDKGNESEMYEISPYATFSVNGGRTGAPAKTPTRAVAAQT 1768
                     :|.|  :..|.||.|.: |...||:.:.|..|::.....| ...|..|...|.|:.
Worm  1390 IELEKATAEKRAQLARSLSVSPSKKL-KRKASEVGDDSQSASYHPKEKR-ARRATVPGAYVTARL 1452

  Fly  1769 PLDYTMQFKTFGHP--EGENL---NATAYPL-------LPSSGF--GHVKSKSSWHKQ------- 1812
            ..|...|......|  .|::.   ..|.|||       |....|  ..|::|.|:.::
Worm  1453 SADRVKQQYRNNQPFIVGDSQLYDGFTNYPLEHNLHYRLMMRAFAKNDVRTKDSFEQRAPMSEKL 1517

  Fly  1813 -RYYNTEDESTLSKSMTIVAGSQAGHSK-----------------------------KSNGGRSA 1847
             |.|:   :|.|::..||.:..:....|                             |.:.||..
Worm  1518 SRMYS---DSVLTEPFTIKSALRGASQKSSPWVGACIAFLVLFSIVGMLICWWLRCNKKSAGRHP 1579

  Fly  1848 KSSAACSGVVAGS----------ESDTSISPSTEF------------------SNMPTYRVPCKS 1884
            :..:.....:.|:          |:...:|.|.|:                  |:|..|.:|...
Worm  1580 RHGSITKVALTGNIMNGGGGIPGETSKLLSTSNEYGRQIMNPYEQMNGNHHMESSMDLYPLPTSH 1644

  Fly  1885 SRSSDGRAVVDMFRPDSSTESNN 1907
            || |:|.|.|.:..|......||
Worm  1645 SR-SNGYAPVPVAIPSLPNNGNN 1666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	6/31 (19%)
		Ig	264..334	CDD:143165	6/28 (21%)
		I-set	345..433	CDD:254352	23/96 (24%)
		Ig	358..431	CDD:143165	21/81 (26%)
		Ig	456..533	CDD:143165	23/76 (30%)
		IGc2	553..619	CDD:197706	16/65 (25%)
		I-set	634..724	CDD:254352	14/89 (16%)
		ig	645..712	CDD:278476	8/66 (12%)
		IG_like	734..815	CDD:214653	12/85 (14%)
		Ig	745..815	CDD:299845	10/72 (14%)
		I-set	820..913	CDD:254352	19/104 (18%)
		Ig	838..920	CDD:299845	20/96 (21%)
		FN3	917..1033	CDD:238020	27/115 (23%)
		FN3	1040..1142	CDD:238020	28/112 (25%)
		fn3	1150..1237	CDD:278470	26/91 (29%)
		FN3	1263..1345	CDD:238020	25/112 (22%)
		Ig	1350..1436	CDD:299845	16/89 (18%)
		IG_like	1358..1436	CDD:214653	14/81 (17%)
		FN3	1441..1530	CDD:238020	19/103 (18%)
		FN3	1542..1620	CDD:238020	18/96 (19%)
ptp-3	NP_001263671.1	I-set	93..184	CDD:254352	23/98 (23%)
		Ig	106..185	CDD:299845	21/86 (24%)
		IG_like	201..287	CDD:214653	26/92 (28%)
		Ig	212..288	CDD:299845	25/82 (30%)
		IG_like	302..378	CDD:214653	20/86 (23%)
		Ig	309..377	CDD:299845	19/73 (26%)
		FN3	383..499	CDD:238020	29/185 (16%)
		FN3	507..600	CDD:238020	20/92 (22%)
		FN3	605..693	CDD:238020	27/115 (23%)
		FN3	700..813	CDD:238020	28/112 (25%)
		FN3	818..918	CDD:238020	28/101 (28%)
		FN3	923..1020	CDD:238020	23/103 (22%)
		FN3	1027..1116	CDD:238020	22/112 (20%)
		fn3	1125..1213	CDD:278470	17/101 (17%)
		PTPc	1694..1949	CDD:214550
		PTPc	1720..1949	CDD:238006
		PTPc	1980..2239	CDD:214550
		PTPc	2008..2239	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910