DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and unc-89

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_001020985.1 Gene:unc-89 / 171990 WormBaseID:WBGene00006820 Length:8081 Species:Caenorhabditis elegans


Alignment Length:2170 Identity:446/2170 - (20%)
Similarity:730/2170 - (33%) Gaps:648/2170 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 CTAHGSPPPLVTWVLRDGSLATQ-------VPGLRKIS-GNGTLHFPPFLAQYYRTDVHEATYRC 116
            |...|.|.|.|:| |.|....||       |.|:.::: .:..|.             |:..|.|
 Worm  3015 CKVIGEPKPKVSW-LHDNKTITQESITVESVEGVERVTITSSELS-------------HQGKYTC 3065

  Fly   117 RASNEAGTVLSR---NVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRPYVRVASWHRGE 178
            .|.|..||..:.   .||..|.|   |...::|.|:.:|...::.|::....:|:|...|:....
 Worm  3066 IAENTEGTSKTEAFLTVQGEAPV---FTKELQNKELSIGEKLVLSCSVKGSPQPHVDFYSFSETT 3127

  Fly   179 --EILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELS 241
              |..:...|.:|..:........:.:..:..|| ::.:..:.||::......|       |..:
 Worm  3128 KVETKITSSSRIAIEHDQTNTHWRMVISQITKED-IVSYKAIATNSIGTATSTS-------KITT 3184

  Fly   242 KNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTWYR----VSDSAALYPIPSSQRVILSR 302
            |..|| ..::.:.:..|:...::.:...:.|:. |...|::    ||:........:.:..:.: 
 Worm  3185 KVEAP-VFEQGLKKTSVKEKEEIKMEVKVGGSA-PDVEWFKDDKPVSEDGNHEMKKNPETGVFT- 3246

  Fly   303 TLLLIKNADERDAGKWICQASNQFG------EQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFN 361
              |::|.|...||||:..:|||..|      |..:...|...::|...:..:|:|   ..||..:
 Worm  3247 --LVVKQAATTDAGKYTAKASNPAGTAESSAEAEVTQSLEKPTFVRELVTTEVKI---NETATLS 3306

  Fly   362 CTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASA 426
            .|..|....:::||.:|:|:|.:::....:  :......|:.:::....|.|.|.|...|....|
 Worm  3307 VTVKGVPDPSVEWLKDGQPVQTDSSHVIAK--VEGSGSYSITIKDARLEDSGKYACRATNPAGEA 3369

  Fly   427 QAMAELKLGDTV--PELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLH---H 486
            :..|...:...:  ||.:.......|:.....:|.....|:|.|...|..|..||...::|   .
 Worm  3370 KTEANFAVVKNLVPPEFVEKLSPLEVKEKESTTLSVKVVGTPEPSVEWFKDDTPISIDNVHVIQK 3434

  Fly   487 RFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNV----YGPPYVRAIGP 547
            :.|:|.|         .|.|:..|..|.|:|.|.|.|..|....:|...:    ..|.:.:.:.|
 Worm  3435 QTAVGSF---------SLTINDARQGDVGIYSCRARNEAGEALTTANFGIIRDSIPPEFTQKLRP 3490

  Fly   548 IKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQ--LVIKNVEPGRDQGIY 610
            ::....|.:.:.....|.||..:.|.|..:.:...|.:..|.....|.  |.||... |.|.|:|
 Worm  3491 LEVREQETLDLKVTVIGTPVPNVEWFKDDKPINIDNSHIFAKDEGSGHHTLTIKQAR-GEDVGVY 3554

  Fly   611 TCIVRSRAGE---EARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDD 672
            ||...:.|||   .|...:|..:.:|..::..| |..:::|..|::...|.....| ...|.|| 
 Worm  3555 TCKATNEAGEAKTTANMAVQEEIEAPLFVQGLK-PYEVEQGKPAELVVRVEGKPEP-EVKWFKD- 3616

  Fly   673 SSIPSSL---QITEKKEEFYS-LLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRY- 732
             .:|.::   .:.|||.|..| .||.||.:....|||||.|:|.|.|.....||::   |::.: 
 Worm  3617 -GVPIAIDNQHVIEKKGENGSHTLVIKDTNNADFGKYTCQATNKAGKDETVGELKI---PKYSFE 3677

  Fly   733 ------------EPM-DTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNH---- 780
                        ||: :|..:.|:|:.:.|:......|.|.:||..       :|:.:..|    
 Worm  3678 KQTAEEVKPLFIEPLKETFAVEGDTVVLECKVNKESHPQIKFFKND-------QPVEIGQHMQLE 3735

  Fly   781 -------SLLLNLATDNDEGYYMCQATNEIG-----AGLKKTIRINVNEP-----------ARFE 822
                   .|.:..|...|.|.|.|:|.|..|     |.||......|.|.           .:||
 Worm  3736 VLEDGNIKLTIQNAKKEDVGAYRCEAVNVAGKANTNADLKIQFAAKVEEHVTDESGQLEEIGQFE 3800

  Fly   823 QSARNISSR--------------RNDPVT------LDCHAKGDEPITIGWTQNNGRIDLNNFRFS 867
            ......||:              |:..||      |.|..||:....|.||:....::::     
 Worm  3801 TVGDTASSKTDTGRGAPEFVELLRSCTVTEKQQAILKCKVKGEPRPKIKWTKEGKEVEMS----- 3860

  Fly   868 IAEMKTEKGVDSQLTIGHSD--RHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGS 930
             |.::.|...|..||:...:  :.|:|.|||.|||.||                           
 Worm  3861 -ARVRAEHKDDGTLTLTFDNVTQADAGEYRCEAENEYG--------------------------- 3897

  Fly   931 RTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDL 995
                                                                             
 Worm  3898 ----------------------------------------------------------------- 3897

  Fly   996 RESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPT---EAPSNVQ-----VQTGGE 1052
                                       ||:||..::.|.|.||.   |||..:|     |.|.||
 Worm  3898 ---------------------------SAWTEGPIIVTLEGAPKIDGEAPDFLQPVKPAVVTVGE 3935

  Fly  1053 SELI---VTWQIPPRESW--NGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRG 1112
            :.::   ::.:..|...|  |||.:       :....:...::.:.:.:.|:      |.|.|..
 Worm  3936 TAVLEGKISGKPKPSVKWYKNGEEL-------KPSDRVKIENLDDGTQRLTV------TNAKLDD 3987

  Fly  1113 LRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQ--------NVNCTALSSQSLKISWL 1169
            :.:|     ...|.|.||. .||....  |.:...:.||.        .|..|..:....|:|..
 Worm  3988 MDEY-----RCEASNEFGD-VWSDVTL--TVKEPAQVAPGFFKELSAIQVKETETAKFECKVSGT 4044

  Fly  1170 EPPLQ-FHGGIIQGYKILYRPIVHQIDFPAKLEIKR---------TSNLETYLHTLHKASNYSIR 1224
            :|.:: |..|.                 |.| |.||         |..|...........||.|.
 Worm  4045 KPDVKWFKDGT-----------------PLK-EDKRVHFESTDDGTQRLVIEDSKTDDQGNYRIE 4091

  Fly  1225 VLAYTATGDGLASH--PLFCQTDDDVPDAPAAIKAAALTAD-----SILISWLTPKNRNGIISHY 1282
            |    :...|:|:.  ||..     ||.....||......:     .||:| :..:.:...:..|
 Worm  4092 V----SNDAGVANSKVPLTV-----VPSETLKIKKGLTDVNVTQGTKILLS-VEVEGKPKTVKWY 4146

  Fly  1283 ----TVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQ 1343
                ||.|.:.       |.:|:|.|:.|.:..||..:::...|...:|..:...|...|     
 Worm  4147 KGTETVTSSQT-------TKIVQVTESEYKLEIESAEMSDTGAYRVVLSTDSFSVESSAT----- 4199

  Fly  1344 ATNTRAPARIA--SF-----GQVVRKAVGTGLVLECLAVGNPTPRARWLTRDRPVTFSPFYEVTN 1401
            .|.|:|..:|:  ||     .|.|.|  ||.||||....|.|.. .:|......:...   :|.:
 Worm  4200 VTVTKAAEKISLPSFKKGLADQSVPK--GTPLVLEVEIEGKPKD-VKWYKNGDEIKDG---KVED 4258

  Fly  1402 EGN----LKIHRVEGSLSGNYTCTANNLFGSDEIQYQV-IAMKPP----SAPQIIVQYASAD-SI 1456
            .||    |.|...:....|.|:.||.|..|..|.:.:| ::.||.    ..|..:.|..:|. ::
 Worm  4259 LGNGKYRLTIPDFQEKDVGEYSVTAANEAGEIESKAKVNVSAKPEIVSGLVPTTVKQGETATFNV 4323

  Fly  1457 RVSWDAPDDGGAPLQGYTISYHTAGESWSITELLPENNAFTISGLKCGNQYIIKMSAHNMVGSGV 1521
            :|.        .|::|  :.::..|:  .|.:...::|......|:..|..:...:.:.:|.|..
 Worm  4324 KVK--------GPVKG--VKWYKNGK--EIPDAKTKDNGDGSYSLEIPNAQVEDAADYKVVVSND 4376

  Fly  1522 ASE-------EINVWTKGKASQAPN-ANELIAT-----NATCVNLKLSSWQNGGCSIHHFSIEHR 1573
            |.:       .:.:...||....|. .:.||.|     .....|:|:..                
 Worm  4377 AGDADSSAALTVKLADDGKDKVKPEIVSGLIPTTVKQGETATFNVKVKG---------------- 4425

  Fly  1574 PLGDIRWTVVTSDISN--AEENRENLIFCDFLPAKWYQL------RISATNDAGKTTEHYHFSTT 1630
            |:..::|.....:|.|  |::|.:.....:...|   ||      ::..:||||........ |.
 Worm  4426 PVKQVKWYKNGKEIPNAKAKDNGDGSYSLEIPNA---QLDDTADYKVVVSNDAGDADSSAAL-TV 4486

  Fly  1631 NIDGITI--------------------------------------PPPSVFP-SENDLMNNLINS 1656
            .:.||.|                                      |.....| |:.|....|:  
 Worm  4487 KLPGIAIVKGLEDAEVPKGKKAVLQVETNKKPKEIKWYKNGKEITPSDKAQPGSDGDNKPQLV-- 4549

  Fly  1657 TNPTSGDWFATLIVVVII----TVSIITIALTIKHRRTLCGPIAEGYESRTLPGDYKEDHENRRN 1717
             .|.:||..|....||:.    ..:..:.|||:|                 ||....:..:...:
 Worm  4550 -IPDAGDDDAAEYKVVLTDEDGNTADSSCALTVK-----------------LPAKEPKIIKGLED 4596

  Fly  1718 QQVYSASPVKTVDKGNESEMYEI----SPYATFSVNGGR--TGAPAKT---------------PT 1761
            |.|...||:|          .||    ||........|:  .||.|||               |:
 Worm  4597 QVVSIGSPIK----------LEIETSGSPKTVKWYKNGKELPGAAAKTIKIQKIDDNKYVLEIPS 4651

  Fly  1762 RAV---------------AAQTPLDYTMQFK-TFGHP-------EGEN----LNATAYP------ 1793
            ..|               :|.:....|::.| ||..|       ||||    :.....|      
 Worm  4652 SVVEDTGDYKVEVANEAGSANSSGKITVEPKITFLKPLKDQSITEGENAEFSVETNTKPRIVKWY 4716

  Fly  1794 -----LLPSSGF---------------GHVKSKSSWHKQRYYNTEDESTLSKSMTIVAGSQAGHS 1838
                 :.|:|.|               ..|:..:..:|....||..|:..|..:| |..::||..
 Worm  4717 KNGQEIKPNSRFIIEQKTDTKYQLVIKNAVRDDADTYKIVLENTAGEAESSAQLT-VKKAKAGLC 4780

  Fly  1839 KKSNG------GRSAKS----------------------SAACSGVVAGSESDT--SISPSTEFS 1873
            |...|      .:.||.                      ||..:.::...:..|  .|.||.:..
 Worm  4781 KIVKGLEDQVVAKGAKMVFEVKIQGEPEDVRWLRDANVISAGANAIIEKIDDTTYRLIIPSADLK 4845

  Fly  1874 NMPTYRVPC---KSSRSSDGRAVVD 1895
            :...|.|..   .....||.:..||
 Worm  4846 DAGEYTVEVINESGKAKSDAKGEVD 4870

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 22/83 (27%)
Ig 56..125 CDD:143165 19/72 (26%)
I-set 246..337 CDD:254352 20/100 (20%)
Ig 264..334 CDD:143165 17/79 (22%)
I-set 345..433 CDD:254352 19/87 (22%)
Ig 358..431 CDD:143165 15/72 (21%)
Ig 456..533 CDD:143165 22/79 (28%)
IGc2 553..619 CDD:197706 18/67 (27%)
I-set 634..724 CDD:254352 30/93 (32%)
ig 645..712 CDD:278476 23/70 (33%)
IG_like 734..815 CDD:214653 23/97 (24%)
Ig 745..815 CDD:299845 19/85 (22%)
I-set 820..913 CDD:254352 29/114 (25%)
Ig 838..920 CDD:299845 22/83 (27%)
FN3 917..1033 CDD:238020 4/115 (3%)
FN3 1040..1142 CDD:238020 24/111 (22%)
fn3 1150..1237 CDD:278470 21/104 (20%)
FN3 1263..1345 CDD:238020 18/90 (20%)
Ig 1350..1436 CDD:299845 28/97 (29%)
IG_like 1358..1436 CDD:214653 25/82 (30%)
FN3 1441..1530 CDD:238020 14/100 (14%)
FN3 1542..1620 CDD:238020 17/90 (19%)
unc-89NP_001020985.1 SH3 65..124 CDD:302595
RhoGEF 153..328 CDD:238091
PH_unc89 341..455 CDD:270134
Ig 568..634 CDD:143165
I-set <570..638 CDD:254352
I-set 648..737 CDD:254352
Ig 661..728 CDD:299845
I-set 748..837 CDD:254352
IGc2 761..827 CDD:197706
I-set 844..935 CDD:254352
I-set 946..1034 CDD:254352
Ig 954..1034 CDD:299845
I-set 1044..1133 CDD:254352
Ig <1060..1132 CDD:299845
I-set 1140..1237 CDD:254352
Ig 1146..1237 CDD:299845
RCSD 1384..1491 CDD:282963
RCSD 1481..1590 CDD:282963
RCSD 1576..1678 CDD:282963
RCSD 1735..1819 CDD:282963
RCSD 1789..>1860 CDD:282963
I-set 1982..2068 CDD:254352
Ig 2009..2069 CDD:299845
Ig_TrkABC_d4 2075..2164 CDD:143173
I-set 2081..2164 CDD:254352
I-set 2171..2262 CDD:254352
Ig <2198..2262 CDD:299845
I-set 2269..2360 CDD:254352
Ig 2270..2360 CDD:299845
I-set 2367..2456 CDD:254352
IGc2 2380..2446 CDD:197706
I-set 2463..2554 CDD:254352
Ig 2490..2554 CDD:299845
I-set 2563..2652 CDD:254352
Ig 2579..2647 CDD:143165
I-set 2659..2747 CDD:254352
Ig 2667..2747 CDD:299845
I-set 2754..2843 CDD:254352
Ig 2777..2841 CDD:143165
I-set 2887..2981 CDD:254352
Ig 2904..2978 CDD:143165
I-set 2994..3082 CDD:254352 20/80 (25%)
IGc2 3009..3072 CDD:197706 18/70 (26%)
I-set 3087..3183 CDD:254352 18/106 (17%)
Ig 3101..3179 CDD:299845 12/78 (15%)
I-set 3189..3279 CDD:254352 19/94 (20%)
Ig 3206..3276 CDD:299845 16/73 (22%)
I-set 3286..3377 CDD:254352 20/95 (21%)
Ig 3303..3374 CDD:143165 15/72 (21%)
I-set 3384..3472 CDD:254352 25/96 (26%)
Ig 3402..3472 CDD:143165 22/78 (28%)
I-set 3482..3573 CDD:254352 24/91 (26%)
Ig 3501..3570 CDD:143165 20/69 (29%)
I-set 3580..3671 CDD:254352 31/94 (33%)
IGc2 3593..3661 CDD:197706 24/70 (34%)
I-set 3686..3776 CDD:254352 23/96 (24%)
IGc2 3699..3766 CDD:197706 17/73 (23%)
I-set 3817..3902 CDD:254352 27/209 (13%)
Ig 3834..3899 CDD:143165 22/189 (12%)
I-set 3920..4010 CDD:254352 22/110 (20%)
Ig 3921..4010 CDD:299845 21/109 (19%)
I-set 4018..4107 CDD:254352 23/110 (21%)
Ig 4046..4107 CDD:299845 18/82 (22%)
Ig 4108..4201 CDD:299845 22/105 (21%)
I-set 4114..4202 CDD:254352 20/100 (20%)
I-set 4212..4298 CDD:254352 27/91 (30%)
IGc2 4226..4288 CDD:197706 19/65 (29%)
I-set 4302..4388 CDD:254352 15/97 (15%)
Ig 4319..4384 CDD:143165 12/76 (16%)
I-set 4400..4486 CDD:254352 19/105 (18%)
Ig 4417..4482 CDD:143165 15/83 (18%)
I-set 4493..4581 CDD:254352 14/90 (16%)
Ig 4518..>4566 CDD:299845 11/50 (22%)
I-set 4588..4679 CDD:254352 18/100 (18%)
Ig 4599..4679 CDD:299845 17/89 (19%)
I-set 4685..4772 CDD:254352 17/87 (20%)
Ig <4713..4772 CDD:299845 10/59 (17%)
I-set 4781..4869 CDD:254352 14/87 (16%)
Ig 4790..4869 CDD:299845 12/78 (15%)
I-set 4873..4962 CDD:254352
Ig 4891..4960 CDD:299845
I-set 4969..5059 CDD:254352
Ig 4985..5051 CDD:143165
I-set 5073..5161 CDD:254352
Ig 5094..5161 CDD:299845
I-set 5171..5260 CDD:254352
Ig 5189..5255 CDD:143165
I-set 5277..5367 CDD:254352
IGc2 5291..5357 CDD:197706
I-set 5383..5473 CDD:254352
IGc2 5397..5463 CDD:197706
I-set 5487..5577 CDD:254352
IGc2 5501..5567 CDD:197706
I-set 5595..5684 CDD:254352
Ig 5614..5681 CDD:143165
I-set 5701..5791 CDD:254352
IGc2 5714..5781 CDD:197706
I-set 5815..5905 CDD:254352
IGc2 5828..5895 CDD:197706
I-set 5925..6015 CDD:254352
Ig 5939..6015 CDD:299845
I-set 6038..6131 CDD:254352
Ig 6058..6126 CDD:143165
I-set 6150..6240 CDD:254352
Ig 6168..6237 CDD:143165
FN3 6275..6358 CDD:214495
IG_like 6413..6501 CDD:214653
Ig 6427..6499 CDD:143165
I-set 6507..6597 CDD:254352
Ig 6529..6594 CDD:143165
PK_Unc-89_rpt1 6620..6878 CDD:271011
S_TKc 6640..6878 CDD:214567
I-set 7528..7616 CDD:254352
Ig 7546..7616 CDD:299845
FN3 7621..7716 CDD:238020
STKc_Unc-89_rpt2 7781..8035 CDD:271014
S_TKc 7793..8035 CDD:214567
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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