DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Kirrel

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_011238330.1	Gene:	Kirrel / 170643	MGIID:	1891396	Length:	805	Species:	Mus musculus

Alignment Length:	716	Identity:	171/716 - (23%)
Similarity:	266/716 - (37%)	Gaps:	125/716 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 HLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAI--GPIKAV-AGEDIIVHC-PFA 563
            :|.|:.....|...|:|.|:.: ......|:|.|..||....|  ||:..: ||....:.| .|.
Mouse   116 NLEITDAELSDDASYECQATEA-ALRSRRAKLTVLIPPEETRIDGGPVILLQAGTPYNLTCRAFN 179

  Fly   564 GYPVEQIRW--EKAHQE-LTTSNHYELASVADG------GQLVIK--NVEPGRDQGIYTCIVRSR 617
            ..|...|.|  :...|| ..||.  ||  :.||      .||:|:  :::.||   ::||...:.
Mouse   180 AKPAATIIWFRDGTQQEGAVTST--EL--LKDGKRETTISQLLIEPTDLDIGR---VFTCRSMNE 237

  Fly   618 A---GEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSL 679
            |   |:|.  .::|:|:.||.:.....|:.:.||.|...||..::....:.:.|.|....|..:.
Mouse   238 AIPNGKET--SIELDVHHPPTVTLSIEPQTVLEGERVIFTCQATANPEILGYRWAKGGFLIEDAH 300

  Fly   680 QITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNT 744
            :...:....||..         :...:|...|.....|.:..:.|..|||....|..|...:|:.
Mouse   301 ESRYETNVDYSFF---------TEPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSD 356

  Fly   745 ISINCEAEGYPIPTITWFKGQGK------GSKDFKPLSMR----NHSLLLNLATDNDEGYYMCQA 799
            :::.|...|.|..|:||.|....      ||.....||.:    ::.|||...|..|.|.|.|:|
Mouse   357 VTLTCVWVGNPPLTLTWTKKDSNMGPRLPGSPPEANLSAQVLSNSNQLLLKSVTQADAGTYTCRA 421

  Fly   800 -TNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCH-AKGDEPITIGWTQNNGRIDLN 862
             ...||.. ::.:.:.||.|......|...:. |.|...::|. .....|..|.|......:::.
Mouse   422 IVPRIGVA-EREVPLYVNGPPIISSEAVQFAV-RGDGGKVECFIGSTPPPDRIAWAWKENFLEVG 484

  Fly   863 NF-RFSIAEMKTEKGVDSQLTIGHSDRHDSGV-YRCIAENPYGRAEQIIFLAVQERPDTPSHLEI 925
            .. |:::....:..||.|.|||.:....|... |.|.|.|.:|....||.|  :||       |:
Mouse   485 TLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL--EER-------EV 540

  Fly   926 FEVG---SRTVKLSWRRPFDGNSPVLSY--LVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPST 985
            ..||   ..|:..       |...|.|:  ||.:...:...|...:.....|.....:|.. |.|
Mouse   541 LPVGIIAGATIGA-------GILVVFSFAALVFFLYRRRKGSRKDVTLRKLDIKVETVNRE-PLT 597

  Fly   986 SISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLK---------TQEE----A 1037
            ..|...|.       .|.::.||..   |:||    .|::.:.:.||         |:||    .
Mouse   598 MHSDREDD-------TASISTATRV---MKAI----YSSFKDDVDLKQDLRCDTIDTREEYEMKD 648

  Fly  1038 PTEAPSNVQV---QTGGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKST- 1098
            ||....||:.   :....:.|...::.|....::|.......:.|...| :|..|...:|...|
Mouse   649 PTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQ-LNTYSRAPASDYGTE 712

  Fly  1099 ------IVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPW-SAAIFGTTAEGVPEAAPQNVNC 1156
                  ...|...|.:.|    .|..|       ..|.|.|: .||.:.|...|.|:|.|..:..
Mouse   713 PTPSGPSAPGGTDTTSQL----SYENY-------EKFNSHPFPGAAGYPTYRLGYPQAPPSGLER 766

  Fly  1157 T 1157
            |
Mouse   767 T 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	6/29 (21%)
		IGc2	553..619	CDD:197706	22/80 (28%)
		I-set	634..724	CDD:254352	15/89 (17%)
		ig	645..712	CDD:278476	11/66 (17%)
		IG_like	734..815	CDD:214653	25/91 (27%)
		Ig	745..815	CDD:299845	22/80 (28%)
		I-set	820..913	CDD:254352	23/95 (24%)
		Ig	838..920	CDD:299845	22/84 (26%)
		FN3	917..1033	CDD:238020	25/129 (19%)
		FN3	1040..1142	CDD:238020	21/112 (19%)
		fn3	1150..1237	CDD:278470	2/8 (25%)
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Kirrel	XP_011238330.1	Ig	54..148	CDD:386229	8/32 (25%)
		Ig2_KIRREL3-like	170..251	CDD:143236	24/89 (27%)
		Ig	255..336	CDD:386229	15/89 (17%)
		Ig_3	340..421	CDD:372822	24/80 (30%)
		Ig5_KIRREL3	439..536	CDD:143306	24/99 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810