DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Lrig1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_032403.2	Gene:	Lrig1 / 16206	MGIID:	107935	Length:	1091	Species:	Mus musculus

Alignment Length:	1300	Identity:	279/1300 - (21%)
Similarity:	420/1300 - (32%)	Gaps:	407/1300 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VLATPLLATSGLRVPTFLLEPAPRLL---------FGNDTGAQ--------VTCTAHGSPPPLVT 71
            ||..|.|              |||||         :....|||        ..||..|.
Mouse     8 VLGAPRL--------------APRLLLWLLLLLLQWPESAGAQAGPRAPCAAACTCAGD------ 52

  Fly    72 WVLRDGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEATYRCRASNEAGTVLSRNVQVHAVV 136
                  ||        ..||.|....|..|..:.|: ::.:..|....:.|......|:|
Mouse    53 ------SL--------DCSGRGLATLPRDLPSWTRS-LNLSYNRLSEIDSAAFEDLTNLQ----- 97

  Fly   137 RRQFHVHVENTEVYLGNSALIKCAIPEYVRPYVRVAS-WHRGEEILLPDLSDVAG----RYVVLA 196
                       ||||.::.|  .|||......:.|.| :.:..:||..|.|.:..    ..:.|:
Mouse    98 -----------EVYLNSNEL--TAIPSLGAASIGVVSLFLQHNKILSVDGSQLKSYLSLEVLDLS 149

  Fly   197 ASGDLYVRSVRSEDGLM---------KFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQKP 252
            ::....:||....:||.         :.|.|.:...:| ..||    |....||||   |.||.|
Mouse   150 SNNITEIRSSCFPNGLRIRELNLASNRISILESGAFDG-LSRS----LLTLRLSKN---RITQLP 206

  Fly   253 VMEIHVERGNDVHLPCN----IQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADER 313
            |....:.|...:.|..|    |:|..|      :..||..:..:   ||..:||.         .
Mouse   207 VKAFKLPRLTQLDLNRNRIRLIEGLTF------QGLDSLEVLRL---QRNNISRL---------T 253

  Fly   314 DAGKWICQASNQFGEQRIEI-RLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHN 377
            |...|        |..::.: .|..||.|.         ||||..         ..:.|:..||
Mouse   254 DGAFW--------GLSKMHVLHLEYNSLVE---------VNSGSL---------YGLTALHQLH- 291

  Fly   378 GKPLQANNALTTGRDNIRFLSKSSLLV---QNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVP 439
               |..|:.....||...|..|...|:   .|:.|.|        |...|...:::.|:|....
Mouse   292 ---LSNNSISRIQRDGWSFCQKLHELILSFNNLTRLD--------EESLAELSSLSILRLSHNA- 344

  Fly   440 ELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSG-----D 499
                   ..::..|....||                |..::|  |.|....|...|.||     |
Mouse   345 -------ISHIAEGAFKGLK----------------SLRVLD--LDHNEISGTIEDTSGAFTGLD 384

  Fly   500 VISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVR-----AIGPIK-----AVAGE 554
            .:|.|.:.      |...|.||..:...::....||: |...:|     |...:|     .::.|
Mouse   385 NLSKLTLF------GNKIKSVAKRAFSGLESLEHLNL-GENAIRSVQFDAFAKMKNLKELYISSE 442

  Fly   555 DIIVHCPFAGYPVEQIRW------EKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCI 613
            ..:..|        |::|      .:..|...|:              ...:.|..:.|.|::.:
Mouse   443 SFLCDC--------QLKWLPPWLMGRMLQAFVTA--------------TCAHPESLKGQSIFSVL 485

  Fly   614 VRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQE--------GGRAQITC-AVSSGDMPIYFSWK 669
            ..|.                 |.:.|..|:.:.:        |...:.|| |.||...|:.|:||
Mouse   486 PDSF-----------------VCDDFPKPQIITQPETTMAVVGKDIRFTCSAASSSSSPMTFAWK 533

  Fly   670 KDDSSIPSS---------LQITEKKEEFYSLLVFKDISARHSGKYTCYASN-AAAKVNYTAELQV 724
            ||:..:.::         .|..|.. |:.::|..:.::..|.|:|.|..:| ..:..::.|.|.|
Mouse   534 KDNEVLANADMENFAHVRAQDGEVM-EYTTILHLRHVTFGHEGRYQCIITNHFGSTYSHKARLTV 597

  Fly   725 RVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLL----LN 785
            .|.|.:...|.|.||..|.|..:.|.|.|:|.|.|.|   |..|..||.....|...::    :.
Mouse   598 NVLPSFTKIPHDIAIRTGTTARLECAATGHPNPQIAW---QKDGGTDFPAARERRMHVMPDDDVF 659

  Fly   786 LATD---NDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEP 847
            ..||   :|.|.|.|.|.|..|: :.....:.|.|.........:......:.|...|.|.|...
Mouse   660 FITDVKIDDMGVYSCTAQNSAGS-VSANATLTVLETPSLAVPLEDRVVTVGETVAFQCKATGSPT 723

  Fly   848 ITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLA 912
            ..|.|.: .||      ..|:.|.......:..|.:.:....|:|.|.|...||.|.......|:
Mouse   724 PRITWLK-GGR------PLSLTERHHFTPGNQLLVVQNVMIDDAGRYTCEMSNPLGTERAHSQLS 781

  Fly   913 VQERPDTPSHLEIFEVGSRTVKLSWRRPFDGN-----------SPVLSYLVQ----YQALK---- 958
            :...|           |.|.         ||.           |.||:.||.    ||..|
Mouse   782 ILPTP-----------GCRK---------DGTTVGIFTIAVVCSIVLTSLVWVCIIYQTRKKSEE 826

  Fly   959 -----------------YLQSHGSLA---------AAGGDWNGHVIN--VSLPSTSISRSYD--- 992
                             ||.|.|:|:         ..|...|||:.:  |.|...|:....|
Mouse   827 YSVTNTDETIVPPDVPSYLSSQGTLSDRQETVVRTEGGHQANGHIESNGVCLRDPSLFPEVDIHS 891

  Fly   993 SDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAP-TEAPSNVQVQTGGESELI 1056
            :..|:..:..|.|...     .:...:.:|:|            || |.|.|...|.:...::..
Mouse   892 TTCRQPKLCVGYTREP-----WKVTEKADRTA------------APHTTAHSGSAVCSDCSTDTA 939

  Fly  1057 VTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKY-SRY- 1119
            ...|..||:|....    |.:..|.:|:....|..:.      .||.|....||.|...| |.:
Mouse   940 YHPQPVPRDSGQPG----TASSQELRQHDREYSPHHP------YSGTADGSHTLSGGSLYPSNHD 994

  Fly  1120 ----AVTIRAMNSFGSG--PWSAAIF-----------GTTAEGVPEAAPQNVNCTALSSQSLKIS 1167
                ::..:|.::.|:|  .|:.|..           .|.|.|.||.....::..|   |.|.:|
Mouse   995 RILPSLKNKAASADGNGDSSWTLAKLHEADCIDLKPSPTLASGSPELMEDAISTEA---QHLLVS 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	17/84 (20%)
		Ig	56..125	CDD:143165	15/76 (20%)
		I-set	246..337	CDD:254352	21/95 (22%)
		Ig	264..334	CDD:143165	14/74 (19%)
		I-set	345..433	CDD:254352	19/90 (21%)
		Ig	358..431	CDD:143165	15/75 (20%)
		Ig	456..533	CDD:143165	17/81 (21%)
		IGc2	553..619	CDD:197706	10/71 (14%)
		I-set	634..724	CDD:254352	26/108 (24%)
		ig	645..712	CDD:278476	21/85 (25%)
		IG_like	734..815	CDD:214653	27/87 (31%)
		Ig	745..815	CDD:299845	21/76 (28%)
		I-set	820..913	CDD:254352	19/92 (21%)
		Ig	838..920	CDD:299845	19/81 (23%)
		FN3	917..1033	CDD:238020	31/165 (19%)
		FN3	1040..1142	CDD:238020	24/120 (20%)
		fn3	1150..1237	CDD:278470	3/17 (18%)
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
Lrig1	NP_032403.2	leucine-rich repeat	53..71	CDD:275380	7/25 (28%)
		LRR_RI	57..325	CDD:238064	79/342 (23%)
		LRR 1	71..92		3/21 (14%)
		leucine-rich repeat	72..95	CDD:275380	3/23 (13%)
		LRR_8	73..129	CDD:290566	15/74 (20%)
		LRR 2	95..116		10/38 (26%)
		LRR 3	118..139		6/20 (30%)
		LRR_8	142..225	CDD:290566	23/90 (26%)
		LRR 4	142..163		3/20 (15%)
		leucine-rich repeat	143..166	CDD:275380	4/22 (18%)
		LRR 5	166..187		2/20 (10%)
		leucine-rich repeat	167..190	CDD:275380	3/23 (13%)
		leucine-rich repeat	191..214	CDD:275380	11/29 (38%)
		LRR 6	191..212		11/27 (41%)
		LRR_8	213..273	CDD:290566	17/85 (20%)
		LRR 7	214..235		6/26 (23%)
		leucine-rich repeat	215..238	CDD:275380	5/28 (18%)
		LRR_RI	238..>423	CDD:238064	55/267 (21%)
		LRR 8	238..259		7/40 (18%)
		leucine-rich repeat	239..262	CDD:275380	7/42 (17%)
		LRR_8	261..321	CDD:290566	18/81 (22%)
		LRR 9	262..283		8/38 (21%)
		leucine-rich repeat	263..286	CDD:275380	8/40 (20%)
		LRR 10	286..307		7/24 (29%)
		leucine-rich repeat	287..310	CDD:275380	7/26 (27%)
		LRR_8	310..369	CDD:290566	16/92 (17%)
		LRR 11	310..331		6/28 (21%)
		leucine-rich repeat	311..334	CDD:275380	6/30 (20%)
		LRR 12	334..355		3/28 (11%)
		leucine-rich repeat	335..358	CDD:275380	5/46 (11%)
		LRR 13	358..380		8/23 (35%)
		leucine-rich repeat	359..383	CDD:275380	7/25 (28%)
		LRR_8	385..441	CDD:290566	12/62 (19%)
		LRR 14	385..406		6/26 (23%)
		leucine-rich repeat	386..409	CDD:275380	6/28 (21%)
		LRR 15	409..430		5/21 (24%)
		leucine-rich repeat	410..433	CDD:275380	5/23 (22%)
		LRRCT	444..492	CDD:214507	10/86 (12%)
		Ig_3	496..583	CDD:290638	21/87 (24%)
		I-set	497..597	CDD:254352	24/100 (24%)
		I-set	601..691	CDD:254352	28/93 (30%)
		Ig_1	618..692	CDD:143240	21/77 (27%)
		I-set	695..782	CDD:254352	19/93 (20%)
		IGc2	709..772	CDD:197706	17/69 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..990		22/99 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1059..1091
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910