DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and CNTN4

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	NP_001193884.1	Gene:	CNTN4 / 152330	HGNCID:	2174	Length:	1026	Species:	Homo sapiens

Alignment Length:	1375	Identity:	276/1375 - (20%)
Similarity:	455/1375 - (33%)	Gaps:	473/1375 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLGALLLAVLATPLLATSGLRVPTFLLEPAPRL--LFGNDTGAQVTCTAHGSPPPLVTWVLR-- 75
            |:|.:.:|.     |...|.|..|.|:.||:|.:  |...:...::.|...|:|.|.:.|.|.
Human     8 LVLQSFILC-----LADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGT 67

  Fly    76 -------------DGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEATYRCRASNEAGTVLS 127
                         :|||....|...:.:|                     ||:|.|:|..||::|
Human    68 DVDTGMDFRYSVVEGSLLINNPNKTQDAG---------------------TYQCTATNSFGTIVS 111

  Fly   128 RNVQVHAVVRRQFHVHVENT-EVYLGNSALIKCAIPEYVRPYVRVASWHRGEEIL------LPDL 185
            |..::.......|.....:| .|..|...::.|..|.           |.||...      .|..
Human   112 REAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPP-----------HSGELSYAWIFNEYPSY 165

  Fly   186 SDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSKNLAPRTTQ 250
            .|  .|..|...:|:||:..|...| :..::|:||||:...:
Human   166 QD--NRRFVSQETGNLYIAKVEKSD-VGNYTCVVTNTVTNHK----------------------- 204

  Fly   251 KPVMEIHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIKNADERDA 315
                               :.|.|.|                            |:::|  :...
Human   205 -------------------VLGPPTP----------------------------LILRN--DGVM 220

  Fly   316 GKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLH-NGK 379
            |::         |.:||::           .|:......|.|....|...|:.:..|.|.. :||
Human   221 GEY---------EPKIEVQ-----------FPETVPTAKGATVKLECFALGNPVPTIIWRRADGK 265

  Fly   380 PLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAEL----------KL 434
            |:        .|...|..|...|.:.|..:.|.|:|:|:.||.|....|..:|          |:
Human   266 PI--------ARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKI 322

  Fly   435 GDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGD 499
            .|     |:..:|:||      ..:|.|:|.|.|.:.||.:.:|::   ...|..|.|
Human   323 ND-----IHVAMEENV------FWECKANGRPKPTYKWLKNGEPLL---TRDRIQIEQ------- 366

  Fly   500 VISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAG 564
              ..|||:.|...|.|:|:|:|.|..|.:..:|.|:|.      |:||
Human   367 --GTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVI------AVGP----------------- 406

  Fly   565 YPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLN 629
                                       |..:.::|.|         |.:
Human   407 ---------------------------DFSRTLLKRV---------TLV---------------- 419

  Fly   630 VNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVF 694
                            :.||...|.|...:...|:| :|||....:..:.:||..::....::
Human   420 ----------------KVGGEVVIECKPKASPKPVY-TWKKGRDILKENERITISEDGNLRII-- 465

  Fly   695 KDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCE-AEGYPIPT 758
             :::...:|.|||.|:|.....:.|..|.|:...|....|....:.:|.:|.:.|: ...:.:..
Human   466 -NVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDI 529

  Fly   759 I-TWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFE 822
            : ||              |...|  |::...|.|                            .||
Human   530 VFTW--------------SFNGH--LIDFDRDGD----------------------------HFE 550

  Fly   823 QSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQLTIGHSD 887
            :                          :|...:.|.:.:.|.:.
Human   551 R--------------------------VGGQDSAGDLMIRNIQL--------------------- 568

  Fly   888 RHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLV 952
            :| :|.|.|:.:....|......|.|:..|..|..:.|.|:...|.:||||...|.:||:..|::
Human   569 KH-AGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVI 632

  Fly   953 Q--------YQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATT 1009
            |        :||:.                      ::|.....:::      :|.|.||.|...
Human   633 QARTPFSVGWQAVS----------------------TVPELIDGKTF------TATVVGLNPWVE 669

  Fly  1010 FLIRMQAINEI---ERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGEL 1071
            :..|..|.|.|   |.|..:|.  .:|:|..|...|:||....|.:|||::||:..|.|..||..
Human   670 YEFRTVAANVIGIGEPSRPSEK--RRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRG 732

  Fly  1072 IGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSA 1136
            .||.|......:.|..::|:.|:..|..|       .....:..:|.:.|.:...|:.|.||:|.
Human   733 FGYVVAFRPYGKMIWMLTVLASADASRYV-------FRNESVHPFSPFEVKVGVFNNKGEGPFSP 790

  Fly  1137 AIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKLE 1201
            .....:||..|...|.::...:||:..:::.|.. ||:.:.|.||||::.|..  |:.......:
Human   791 TTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEVKYWR--HEDKEENARK 852

  Fly  1202 IKRTSN-LETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSI 1265
            |:...| ..|.:..|..:..|.:.|.||.:.|.|.:|..:...|....|..|........:...|
Human   853 IRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKI 917

  Fly  1266 LISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSAST 1330
            :::|                       .|.|......:..||.|           :|.:...:||
Human   918 ILNW-----------------------DQVKALDNESEVKGYKV-----------LYRWNRQSST 948

  Fly  1331 SVGEGEPTSV 1340
            ||.|...|||
Human   949 SVIETNKTSV 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	20/91 (22%)
		Ig	56..125	CDD:143165	17/83 (20%)
		I-set	246..337	CDD:254352	9/90 (10%)
		Ig	264..334	CDD:143165	9/69 (13%)
		I-set	345..433	CDD:254352	24/98 (24%)
		Ig	358..431	CDD:143165	20/73 (27%)
		Ig	456..533	CDD:143165	22/76 (29%)
		IGc2	553..619	CDD:197706	4/65 (6%)
		I-set	634..724	CDD:254352	19/89 (21%)
		ig	645..712	CDD:278476	16/66 (24%)
		IG_like	734..815	CDD:214653	11/82 (13%)
		Ig	745..815	CDD:299845	9/71 (13%)
		I-set	820..913	CDD:254352	11/92 (12%)
		Ig	838..920	CDD:299845	11/81 (14%)
		FN3	917..1033	CDD:238020	29/126 (23%)
		FN3	1040..1142	CDD:238020	28/101 (28%)
		fn3	1150..1237	CDD:278470	23/87 (26%)
		FN3	1263..1345	CDD:238020	16/78 (21%)
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
CNTN4	NP_001193884.1	Ig	25..118	CDD:325142	26/113 (23%)
		Ig	120..213	CDD:325142	26/176 (15%)
		Ig	225..313	CDD:325142	26/106 (25%)
		Ig	318..401	CDD:325142	30/105 (29%)
		Ig5_Contactin	422..494	CDD:319278	19/75 (25%)
		Ig6_Contactin-4	513..597	CDD:143261	21/175 (12%)
		FN3	597..690	CDD:238020	28/120 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710		8/26 (31%)
		FN3	703..795	CDD:238020	28/98 (29%)
		FN3	804..896	CDD:238020	24/94 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..907		5/20 (25%)
		FN3	904..989	CDD:238020	17/89 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910