DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and Dscam

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus

Alignment Length:	2076	Identity:	637/2076 - (30%)
Similarity:	972/2076 - (46%)	Gaps:	225/2076 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPPFLAQYYRTDVHEA 112
            ::|.:.:|..|.|.|.|.||..:.|.|..|.....|||:|.:..||||...||....:.|.:|:.
Mouse    34 VVFASTSGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDN 98

  Fly   113 TYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRPYVRVASWHRG 177
            ||.|.|.|.:|.:.|::|.:.||:|..:.|.||:.:...||.|:.||.||..|..||.|.||.:
Mouse    99 TYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYVTVVSWEK- 162

  Fly   178 EEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVMLQVKELSK 242
                 ..:|.|:|...::.::|.||::.|::||||..:.|:..:...||.::|::..|.|.:
Mouse   163 -----DTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD--- 219

  Fly   243 NLAPRTTQKPVMEIHVER----GNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVILSRT 303
               |..:...:::....|    |..|.|||...|:|.|.:.|.:.:     .|:..|.|...:.|
Mouse   220 ---PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDN-----MPLELSGRFQKTVT 276

  Fly   304 LLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSA 368
            .|||:|:...|:|.::|:.||::|..::..||.|...:...|.|:....:.|...:.:|:.||:.
Mouse   277 GLLIENSRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGNE 341

  Fly   369 IDAIDWLHNGKPLQ-ANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAEL 432
            ...:.|..||:.|. ..|...||      |:.::|::.::.:.|.|.|||.|...:.|||...::
Mouse   342 DQELSWYRNGEILNPGKNVRITG------LNHANLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQV 400

  Fly   433 KLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMS 497
            .|.|..|::|..|.|:.|.|...:||.|:..|:|.|...|.||..||:..|.|.   |.|.:...
Mouse   401 VLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPTVTWTLDDDPILKGSGHR---ISQMITSE 462

  Fly   498 GDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPF 562
            |:|:|:||||..:..|||:|:|.|:||.|.|.:.||:||.||..:|.:..|.|:||.|..:||..
Mouse   463 GNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRV 527

  Fly   563 AGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQ 627
            .|||...|:|.| :..|...||.::| ..:.|.|.:.:|:...|:|.|||.|..:......:.:.
Mouse   528 IGYPYYSIKWYK-NANLLPFNHRQVA-FENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVH 590

  Fly   628 LNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLL 692
            :.|..||.|:||:||: ...|.|..|.|.|.|||:||..:|:||...||:||.:|....:|.|.|
Mouse   591 VTVKVPPFIQPFEFPR-FSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSL 654

  Fly   693 VFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIP 757
            ...::|..|:|.|||.|.|.||.|.:.::|.|||.|::..:|.|...:.|..:.:||.|||||:|
Mouse   655 RISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVP 719

  Fly   758 TITWFKGQGKGSKDFKPLSMR-------NHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINV 815
            ||.|...:|.|...|:|:::.       |.|||:....:.|.|||:|:.:|::||.:.|::.:.|
Mouse   720 TIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784

  Fly   816 NEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDSQ 880
            ..||..........:.:.....:.|.|.|::||.:.|.:.:..|:....|:.::..:..:.|.|.
Mouse   785 KIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVIST 849

  Fly   881 LTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNS 945
            |.|..:.|.|||.:.|.|.|.||....||.|.|||.|| |..:||.:|.:||:.|.|...|||||
Mouse   850 LQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD-PPEIEIKDVKARTITLRWTMGFDGNS 913

  Fly   946 PVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYD-SDLRESAIVAGLTPATT 1009
            |:..|.::.:                       |.|....|..|:.| |....||.:..:.|::|
Mouse   914 PITGYDIECK-----------------------NKSDSWDSAQRTKDVSPQLNSATIIDIHPSST 955

  Fly  1010 FLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGY 1074
            :.|||.|.|.|.:|..:..|.:...|.||...|..|.::......:.|||:.|.:...||.:.||
Mouse   956 YSIRMYAKNRIGKSEPSNEITITADEAAPDGPPQEVHLEPTSSQSIRVTWKAPKKHLQNGIIRGY 1020

  Fly  1075 TVNCSEEKQNINF---ISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSA 1136
            .:...|.....||   |..::::..|.:.        ||..|.|:::|.:.::|.|..|:||.|.
Mouse  1021 QIGYREYSTGGNFQFNIISIDTTGDSEVY--------TLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077

  Fly  1137 AIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAKL- 1200
            .|..||.|.||...|:||...|.|.:|:.|||.....:...||:||::::|  ..:.||  .:|
Mouse  1078 EIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIY--WANLID--GELG 1138

  Fly  1201 EIKRTSNLETYLHT--LHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTAD 1263
            |||..:..:..|..  |.|.:||||:|||:|..|||:.|..:|.:|.:|||..||.:||||.:|.
Mouse  1139 EIKNVTTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASAS 1203

  Fly  1264 SILISWLTPKNRNGIISHYTVYSREAGRKGQAKTH---MVRVDENGYPVTFESR--SLAENQMYE 1323
            .:.:|||.|...||||..|||:.          :|   .|..:....|.:|..|  :|:.|:.|.
Mouse  1204 MVFVSWLPPLKLNGIIRKYTVFC----------SHPYPTVISEFEASPDSFSYRIPNLSRNRQYS 1258

  Fly  1324 FWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLECLAVGNPTPRARWL--T 1386
            .||.|.||.|.|..:.:|......:|||||.:|...|.......:||.|.|||:|:|..:|:  :
Mouse  1259 VWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDS 1323

  Fly  1387 RDRP--VTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQVIAMKPPSAPQIIVQ 1449
            ...|  ||......:.:.|:..|..|:...||.|:|.|||.:|||||...:....||..|::.|.
Mouse  1324 NGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCVANNNWGSDEIILNLQVQVPPDQPRLTVS 1388

  Fly  1450 YASADSIRVSWDAPDDGGAPLQGYTISY-HTAGESWSITELLPENNAFTISGLKCGNQYIIKMSA 1513
            ..::.||.:||...|:||:.::||.:.| ....|.|....:.|...::.:..||||..|...::|
Mouse  1389 KTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTA 1453

  Fly  1514 HNMVGSGVASEEINVWTKGKASQAPNANELIAT-NATCVNLKLSSWQNGGCSIHHFSIEHRPLGD 1577
            .|.||.|..||.|...|.||..|.....||.|: |.|.|.|.|..|.:|||.|..|::|:||.|.
Mouse  1454 QNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGT 1518

  Fly  1578 IRWTVV-TSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGITIPP-- 1639
            ..||.. .:.:|      ::.|..|...|.||:|::...|.||...:..:|:|.|.||.||||
Mouse  1519 TVWTTAQRTSLS------KSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLI 1577

  Fly  1640 PSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSII---TIALTIKHRRTL--------CG 1693
            .||..||..|          |:.:....|:.:..|.|.::   .:.|.::.||..        ..
Mouse  1578 KSVVQSEEGL----------TTNEGLKILVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAK 1632

  Fly  1694 PIAE---GYESRTLPGDYKEDHENRRNQQVYSA-------SPVKTVDK-----------GNESEM 1737
            .:||   ...:||.....|:....|.:..:..|       ..::|:|.           |..::.
Mouse  1633 SLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQ 1697

  Fly  1738 ----------YEISPYAT---FSVNGGRTGAPAKTPTRAVAAQTPLD-YTMQFKTFGHPE---GE 1785
                      |:....||   ..|:..|.|....|...|.|..|..: |..|: |...|.   ..
Mouse  1698 KSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQW-TLNRPHPTISA 1761

  Fly  1786 NLNATAYPLLPSSGFGHVKSKSSWHKQRYYNTEDE------STLSKSMTIVAGSQA-GHSKKSNG 1843
            :...|.:.|......|.|..:|..:........|.      ||.|.|.|....::| .|:|....
Mouse  1762 HTLTTDWRLPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQ 1826

  Fly  1844 GRSAK--------SSAACSGVVAGSESDTSISPSTEFSNMPTYRVPCKSSRSSDGRAVVDMFRPD 1900
            .|.||        |..:...:.||:...|....|:..|.....|......:..||..||:|..|.
Mouse  1827 LRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVVNMAVPK 1891

  Fly  1901 SSTESNNDQGSPAPERRHNTPRHVLG----------MGMAMGLGG-GGGGGVGGGNG-------- 1946
            :.......:.|.:..:..:.|...||          |...:..|. |....:..|..
Mouse  1892 AHRPVLETRSSKSRHQLTHVPLRALGDLIHLPPYLRMDFLLNRGAPGTSRDLSLGQACLEPQKSR 1956

  Fly  1947 -----------PAEKRSA------GQRSRKHGSAAQQPSNQTLERRKCPGSSNSLDSEVDA 1990
                       |.|..|:      ||:|.:.|:.|..|..:..|..:....|:|.:|.:|:
Mouse  1957 TLKRPTVLEPTPMEASSSTSSTREGQQSWQQGAVATLPQREGAELGQAAKMSSSQESLLDS 2017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	29/76 (38%)
		Ig	56..125	CDD:143165	27/68 (40%)
		I-set	246..337	CDD:254352	27/94 (29%)
		Ig	264..334	CDD:143165	22/69 (32%)
		I-set	345..433	CDD:254352	24/88 (27%)
		Ig	358..431	CDD:143165	21/73 (29%)
		Ig	456..533	CDD:143165	32/76 (42%)
		IGc2	553..619	CDD:197706	23/65 (35%)
		I-set	634..724	CDD:254352	39/89 (44%)
		ig	645..712	CDD:278476	28/66 (42%)
		IG_like	734..815	CDD:214653	31/87 (36%)
		Ig	745..815	CDD:299845	28/76 (37%)
		I-set	820..913	CDD:254352	24/92 (26%)
		Ig	838..920	CDD:299845	29/81 (36%)
		FN3	917..1033	CDD:238020	35/116 (30%)
		FN3	1040..1142	CDD:238020	27/104 (26%)
		fn3	1150..1237	CDD:278470	34/89 (38%)
		FN3	1263..1345	CDD:238020	27/86 (31%)
		Ig	1350..1436	CDD:299845	33/89 (37%)
		IG_like	1358..1436	CDD:214653	28/81 (35%)
		FN3	1441..1530	CDD:238020	29/89 (33%)
		FN3	1542..1620	CDD:238020	29/79 (37%)
Dscam	XP_006522949.1	Ig	15..115	CDD:386229	30/80 (38%)
		IGc2	239..300	CDD:197706	22/65 (34%)
		IG	320..400	CDD:214652	23/85 (27%)
		Ig_3	410..488	CDD:372822	33/80 (41%)
		IGc2	518..575	CDD:197706	20/58 (34%)
		Ig	596..686	CDD:386229	40/90 (44%)
		Ig_DSCAM	707..784	CDD:143211	28/76 (37%)
		Ig	802..889	CDD:386229	29/87 (33%)
		FN3	885..978	CDD:238020	35/116 (30%)
		FN3	986..1083	CDD:238020	27/104 (26%)
		FN3	1091..1184	CDD:238020	36/96 (38%)
		FN3	1189..1278	CDD:238020	35/98 (36%)
		Ig_3	1301..1363	CDD:372822	20/61 (33%)
		FN3	1380..1470	CDD:238020	29/89 (33%)
		FN3	1486..1555	CDD:238020	25/74 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4889
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8769
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.690