DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP001201

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_321956.5	Gene:	AgaP_AGAP001201 / 1281967	VectorBaseID:	AGAP001201	Length:	322	Species:	Anopheles gambiae

Alignment Length:	403	Identity:	84/403 - (20%)
Similarity:	138/403 - (34%)	Gaps:	133/403 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   694 FKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPR------WRYEPMDTAIMLGNTISINCEAE 752
            |.|:::|          |....|:.||.|:.||..:      | ....|..|:..|
Mosquito     5 FDDVNSR----------NVTTVVDDTAVLKCRVKHKGDRTVSW-MRKRDLHILTSN--------- 49

  Fly   753 GYPIPTITWFKGQGKGSKDFK---PLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRIN 814
               |.|.|       |.:.|.   |....:..|.:..|...|.|.|.||...|....|  .:.::
Mosquito    50 ---IYTYT-------GDQRFSVIHPPDSDDWDLKIEYAQQKDSGIYECQVNTEPKINL--AVYLD 102

  Fly   815 VNEPARFEQSARNISS-----RRNDPVTLDC----HAKGDEPITIGWTQNNGR--IDLNNFR--F 866
            |.:.......|:.|.|     ::...::|.|    ||.     :|.|...:|.  :|.::.|  .
Mosquito   103 VTDFLSTAARAKIIGSQEVHVKKGSTISLSCVVNVHAS-----SISWYVYHGSSIVDFDSARGGI 162

  Fly   867 SIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSR 931
            |:...|||.|..|:|.:..:...|||.|.|:.......:.|:..|
Mosquito   163 SLETEKTEGGTSSRLMLTRATLRDSGNYTCVPTGAISASVQVHVL-------------------- 207

  Fly   932 TVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISR--SYDSD 994
                      :|..|.   .:|..:.....:|.:|.         ::.|||.|.::|:  .:.|:
Mosquito   208 ----------NGEHPA---AMQTSSGVPCPTHQTLI---------LLFVSLNSCNVSKLIFFISN 250

  Fly   995 LRE---------------------SAIVAGLTPATTFLIRMQAI--NEIERSAYTEAIVLKTQEE 1036
            |.|                     ||:.||.|.:|.|::...|.  ..:.|:|.       .|.:
Mosquito   251 LLETMRFLLTTTIAHFLLHLRRLPSALGAGRTKSTRFVLLTLATIGTRLRRTAL-------QQRQ 308

  Fly  1037 APTEAPSNVQVQT 1049
            .|..:|.:|:.|:
Mosquito   309 HPAASPCSVRTQS 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352	8/29 (28%)
		ig	645..712	CDD:278476	3/17 (18%)
		IG_like	734..815	CDD:214653	18/83 (22%)
		Ig	745..815	CDD:299845	15/72 (21%)
		I-set	820..913	CDD:254352	26/105 (25%)
		Ig	838..920	CDD:299845	23/89 (26%)
		FN3	917..1033	CDD:238020	23/140 (16%)
		FN3	1040..1142	CDD:238020	3/10 (30%)
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP001201	XP_321956.5	Ig	9..97	CDD:299845	26/117 (22%)
		IG_like	10..92	CDD:214653	25/111 (23%)
		IG_like	118..206	CDD:214653	23/92 (25%)
		IGc2	126..199	CDD:197706	21/77 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810