DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP010222

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_554133.3	Gene:	AgaP_AGAP010222 / 1279645	VectorBaseID:	AGAP010222	Length:	370	Species:	Anopheles gambiae

Alignment Length:	376	Identity:	95/376 - (25%)
Similarity:	138/376 - (36%)	Gaps:	103/376 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 WICQASNQF----GEQRIEIRLSVNSYVSVHILP------QVQIVNSGGTANFNCTTTGSAIDAI 372
            ::..|::.|    |||...|. ..|||:....||      |...|..|..|...|.........:
Mosquito    16 YVLNATHIFATAQGEQDDAIE-ETNSYILDKDLPKFGEPIQNLTVPVGREAVLTCVINNLQTYKV 79

  Fly   373 DWLH---------NGKPLQANNALT----TGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRA 424
            .||.         ....:..|:.:|    .||..:       |.:::|...|:|.|.|.|.....
Mosquito    80 AWLRVDTQTILTIQTHVITKNHRMTIAHVEGRAWV-------LRIRDVKESDKGWYMCQVNTDPM 137

  Fly   425 SAQAMAELKLGDTVPELIY---TFIEQNVRPGPLISLKCSASGSPPPQFAWLLD-SQPI------ 479
            ..|..   .|...||..|.   |..:..||.|..::|||:|||||.|...|..: ::||
Mosquito   138 RNQIG---YLNVVVPPNILDYPTSTDMVVREGSNVTLKCAASGSPTPSIIWRREGNEPISAGGRT 199

  Fly   480 ------MDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSM-GSVQHSARLNVY 537
                  |..||          :.|...||.:|..|:     |.|.|:|||.: .||.....|.|:
Mosquito   200 GVYWVVMTTSL----------NSSTFSISRVNRLHM-----GAYLCIASNGIPPSVSKRVMLIVH 249

  Fly   538 GPPYV----RAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEK--------------AHQELTTSN- 583
            .||.:    :.:|   |..|:.:.:.|....||.....|.|              .|.:||.:|
Mosquito   250 FPPMIWIQDQLVG---AALGQRLTLECQSEAYPRSINYWMKNDTIITQVQTNNKHKHDQLTINNE 311

  Fly   584 ---------HY-----ELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGE 620
                     |:     |:.|.....:|.||::... |.|.|.|:|::..||
Mosquito   312 RCNIISTGKHFEPSIKEINSYKVVMKLTIKDINIA-DFGTYKCVVKNSLGE 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	6/22 (27%)
		Ig	264..334	CDD:143165	5/19 (26%)
		I-set	345..433	CDD:254352	21/106 (20%)
		Ig	358..431	CDD:143165	16/85 (19%)
		Ig	456..533	CDD:143165	28/90 (31%)
		IGc2	553..619	CDD:197706	21/94 (22%)
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP010222	XP_554133.3	IG_like	55..148	CDD:214653	20/102 (20%)
		Ig	55..146	CDD:299845	20/100 (20%)
		IG_like	158..248	CDD:214653	32/104 (31%)
		IGc2	165..234	CDD:197706	25/83 (30%)
		IG_like	263..369	CDD:214653	24/100 (24%)
		Ig	269..367	CDD:143165	22/94 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810