DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP007928

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_317553.4	Gene:	AgaP_AGAP007928 / 1278027	VectorBaseID:	AGAP007928	Length:	1478	Species:	Anopheles gambiae

Alignment Length:	1649	Identity:	329/1649 - (19%)
Similarity:	537/1649 - (32%)	Gaps:	538/1649 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 NCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGR---RDRGVYQ------ 416
            |.|::.|..|| ..:|.      :|.|.||:.:.|...::| ...|.||   .|:.:.:
Mosquito    72 NYTSSSSTSDA-GHVHE------DNPLLTGQYSARVRRRTS-TDSNGGRTTTSDKSLNRLISFLL 128

  Fly   417 --------CLVENQRASAQAMAELKLGDTVPELIYTFIE-QNVRPGPLI---SLKCSASGSPPPQ 469
                    |...|....|..:..: ||::|  :....:: ....|.|.:   ..|.|..|...|.
Mosquito   129 LALCFTLGCCTINPPQDAVHITAI-LGESV--VFNCHVDFPGEHPVPYVLQWEKKVSEKGQEIPI 190

  Fly   470 FAWLLDSQPIMDVSLH----HRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKC-VASNSMGSVQ 529
            |.| .:|.|     .|    :...:.:....|....:.||::.:|..|.|.|:| |...:....|
Mosquito   191 FIW-YESYP-----THSGEGYEGRVSRVPPNSTFGAASLNLTDIRESDQGWYECKVVFLNRPPKQ 249

  Fly   530 HS----ARLNVYGPPYVRAIGP---IKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYEL 587
            |.    ..|:|:.||.. ::.|   |....|:.||::|...|.|..:|.|.|....:..|:...:
Mosquito   250 HKNGTWFHLDVHAPPRF-SVTPEDIIYVNLGDSIILNCQADGTPTPEILWYKDANPVDPSSTVGI 313

  Fly   588 ASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQ--EGGR 650
            .:  ||.:|.|..:. ..|.|.||||.|:..|:.:.....:......::.|   |.|..  ||.:
Mosquito   314 FN--DGTELRISTIR-HEDIGDYTCIARNGEGQVSHTARVIIAGGAVIMVP---PTNQTKLEGEK 372

  Fly   651 AQITCAVSSGDMPIYFSWKKDDSSIPS----SLQITEKKEEFYSLLVFKDISARHSGKYTCYASN 711
            .|.||...:....:...|.::.|.:..    ..::|.:|:   ..|:...:||..||:|||..||
Mosquito   373 VQFTCEAKAMPGNVTVRWFREGSPVREVAALETRVTIRKD---GSLIINPVSADDSGQYTCEVSN 434

  Fly   712 -------AAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKG----Q 765
                   |:|.:|.....:|...|..:|.|...|.::...|..|     .|:..:||.|.    :
Mosquito   435 GIGEPQSASAYLNIEYPAKVTFTPTIQYLPFRLAGVVQCYIKAN-----PPLQYVTWTKDKRLLE 494

  Fly   766 GKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGA-GLKKTIRINVNEPARFEQSARNIS 829
            ...:||.  :.|.|.|||......|.:|.|.|...|..|. |....:.:.|.:|..|......:.
Mosquito   495 PYQTKDI--VIMNNGSLLFTRVNQNHQGRYTCTPYNAQGTQGSSGHMEVLVRKPPAFTVEPDPLY 557

  Fly   830 SRR-NDPVTLDC---HAKGDEPITIGWTQNNGR-IDLNNFRFSIAEMKTEKGVDSQLTIGHSDRH 889
            .|: .:.|.:.|   .|:|.....|.|.:.:|: :..|..|.:          ...:||.:..|.
Mosquito   558 QRKVGESVEMHCDAQEAEGTSKPNIQWQRRDGQPLQKNRVRIN----------SGNITIENLRRS 612

  Fly   890 DSGVYRCIAENPYG---RAEQIIFLAVQERPDTPSHLEIFEVGSRT---VKLSWRRPFDGNSPV- 947
            |.|.|:|:|.|...   .|.|::....|  |..|.:|.    ||.|   |.|||...:.|....
Mosquito   613 DFGYYQCVASNEVATIVSATQLVIEGTQ--PHAPYNLS----GSATEFSVTLSWMPGYSGGPDYK 671

  Fly   948 LSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLI 1012
            ..|.:.|:           .|...:|:      ::|.|....:       ...:..|:|.||:..
Mosquito   672 QDYTIWYR-----------EAGVSEWS------TIPVTPSGST-------QVTINRLSPGTTYEF 712

  Fly  1013 RMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIPPRESWNGELIGYTVN 1077
            ::...|.:.....::.|.::|.:....:.||             .|...|              |
Mosquito   713 QVIGKNALGDGMMSKVITIRTLDAQKAKKPS-------------TTTAAP--------------N 750

  Fly  1078 CSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTT 1142
            ..|.|                                         .|....|..|
Mosquito   751 DKEFK-----------------------------------------HAPEDLGPKP--------- 765

  Fly  1143 AEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYKILYRPIVHQIDFPAK------LE 1201
                  ..|:||....:.:..| |||..|..:.|  ::|.|.|.||     .|...|      :.
Mosquito   766 ------GQPRNVTVVEIPNGFL-ISWQVPLERAH--LVQFYTIKYR-----TDAQWKTLNRGQIR 816

  Fly  1202 IKRTSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVP-DAPAAIKAAALTAD-- 1263
            .:.||.|   :..|.....|..||||     :.|.|:    :|.:::. ..||.:|..|:||.
Mosquito   817 PEETSYL---VKNLVGGRTYYFRVLA-----NSLKSY----ETSEEIKFPVPARVKHKAITAGVV 869

  Fly  1264 --------SILISWLTPK----------------------NRNGIISHYTVYSREAGRKGQAKTH 1298
                    :|::|....|                      :||.:.:|..:  .|..|...|:|:
Mosquito   870 GGILFFIVAIILSICAVKICNKRKRRKQEKELNMVTARLTDRNALKTHDMI--EERWRSILARTY 932

  Fly  1299 MVRVDENGYPVTFESRSLAEN----QMYEFW----------VSASTSVGEGEPTSVIAQATNTRA 1349
            | :.:..|      ||....|    .::..|          :.:|..:|:        |:.|.
Mosquito   933 M-QGERKG------SRMPGLNILIAILHWIWPPGRCQNCDSIYSSKFIGD--------QSMNV-- 980

  Fly  1350 PARIASFGQVVRKAVGTGLVLECLAVGNPTPR-------------------------ARW----- 1384
                   ||:.|.|.|..::.:.|..|..:.|                         |.|
Mosquito   981 -------GQIHRSADGRFVLSQDLVDGIVSLRNSIVSQYSSSDDGGFLPKRLPSLTKASWRRPLV 1038

  Fly  1385 -----LTRDRPVTFSPFYE----------------------VTNE----GNLKIHRVEGSLSGNY 1418
                 |:.....||...:.                      .||.    ||:.:..:..:|..
Mosquito  1039 SYPSQLSLQMETTFGNHHHHHHLHHHGTGPVPQLAQPQQSLYTNTLPEGGNVMVPSISSTLPP-- 1101

  Fly  1419 TCTANNLFGSDEIQYQVIAMKP-PSAPQII--------------VQYASADSIRVSWDAPDD--- 1465
            ...|..::.:.....:|:|..| .|:||::              |.:.|  |...|:..|..
Mosquito  1102 MLAAQTIYTTPSRVSKVVASSPATSSPQVVNSPWSPLYFSDLSSVHHLS--SAERSFPTPQSVHS 1164

  Fly  1466 ----------------------------------GGAPLQGYTIS-------------------- 1476
                                              |..|:....:|
Mosquito  1165 VHRYYNHELPVLQSLQHMSSNHHHHHHHHHHATHGFIPVSDVPVSLPYYYGQPGAQQLPTTLFSR 1229

  Fly  1477 YHTAGESWSITELLPE---------NNAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKG 1532
            |:......|::..:||         .|..::||:  |.......|..:..|.|..:...|.....
Mosquito  1230 YYPRSMPRSVSRTIPELRSPLLNLNLNTTSLSGV--GGLENSPQSYSSSSGFGSKNTSSNNTQPS 1292

  Fly  1533 KASQAPNANELIATNATCVNLKLSSWQ--------NGGCSIHHFS--------IEHRPLGDIRWT 1581
            .||.|     .|||.....:..|..|:        ....|:||.:        .|:.|.....|.
Mosquito  1293 GASSA-----AIATTTGSTHNLLREWRYLPPYRPPPPPPSLHHAAPLSIGGGRFENPPYSMSHWL 1352

  Fly  1582 VVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYHFSTTNIDGITIPPPSVFPSE 1646
            .:.:.::.|.|                :..|:.|.|.|....||.|     |..|..|.:..|:.
Mosquito  1353 ELITRLNIASE----------------KANINNTADVGSVDGHYEF-----DPSTPTPTASTPTG 1396

  Fly  1647 --NDLMNNLINSTNP-TSGD--WFATLIVVVIITVSIITIALTIKHRRTLCGPIAEGYESR---- 1702
              .|..::|:  |.| ||.|  |.||.:..|:.::|               |....| :||
Mosquito  1397 LIRDDFHHLM--TLPSTSSDLLWSATGLAGVVSSLS---------------GGRKRG-QSRYDNI 1443

  Fly  1703 --TLPGDYKEDHENRRNQQVYSAS 1724
              .:....:|.:|.|:.||:.:.|
Mosquito  1444 DARVQAMKEEFYEYRKRQQLQAVS 1467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	19/88 (22%)
		Ig	358..431	CDD:143165	19/86 (22%)
		Ig	456..533	CDD:143165	20/88 (23%)
		IGc2	553..619	CDD:197706	21/65 (32%)
		I-set	634..724	CDD:254352	25/102 (25%)
		ig	645..712	CDD:278476	19/79 (24%)
		IG_like	734..815	CDD:214653	22/85 (26%)
		Ig	745..815	CDD:299845	20/74 (27%)
		I-set	820..913	CDD:254352	22/100 (22%)
		Ig	838..920	CDD:299845	21/88 (24%)
		FN3	917..1033	CDD:238020	23/119 (19%)
		FN3	1040..1142	CDD:238020	10/101 (10%)
		fn3	1150..1237	CDD:278470	26/92 (28%)
		FN3	1263..1345	CDD:238020	19/127 (15%)
		Ig	1350..1436	CDD:299845	19/146 (13%)
		IG_like	1358..1436	CDD:214653	18/138 (13%)
		FN3	1441..1530	CDD:238020	23/168 (14%)
		FN3	1542..1620	CDD:238020	16/93 (17%)
AgaP_AGAP007928	XP_317553.4	IG_like	148..240	CDD:214653	22/100 (22%)
		Ig	155..241	CDD:299845	20/93 (22%)
		I-set	264..352	CDD:254352	25/91 (27%)
		IGc2	279..342	CDD:197706	21/65 (32%)
		I-set	357..448	CDD:254352	24/96 (25%)
		Ig	<387..448	CDD:299845	16/63 (25%)
		Ig	470..541	CDD:299845	20/77 (26%)
		IG_like	560..636	CDD:214653	20/85 (24%)
		IGc2	562..625	CDD:197706	18/72 (25%)
		FN3	641..733	CDD:238020	23/119 (19%)
		FN3	765..839	CDD:238020	24/99 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810