DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and AgaP_AGAP004902

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_001688600.1 Gene:AgaP_AGAP004902 / 1275709 VectorBaseID:AGAP004902 Length:1874 Species:Anopheles gambiae


Alignment Length:1961 Identity:669/1961 - (34%)
Similarity:988/1961 - (50%) Gaps:214/1961 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 LEPAPRLLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISGNGTLHFPPFLAQYYR 106
            :||..||.|.|.:|..:.|:|.|||.|.:.|:..||:....|.|:|::..||||...||.|..||
Mosquito     1 MEPPSRLEFSNSSGGWLDCSASGSPQPSIDWLSVDGTSVGDVGGVRRVLRNGTLVLLPFPATAYR 65

  Fly   107 TDVHEATYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRPYVRV 171
            .|:|...|||.|||..|.|:||:|||.|||.:.:.|.||......|.:|:::|.:|.:|:..|||
Mosquito    66 QDIHSTIYRCVASNTVGRVISRDVQVRAVVAQAYKVDVEVLAASRGCTAILRCVVPNFVKELVRV 130

  Fly   172 ASWHRGEEI-LLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTNTLNGERQRSDAVML 235
            .||.:.... :.|.|.. .|:|.:| .:|:|.:.::...|....:.|...:.|..:...|::..:
Mosquito   131 VSWVQEPAFYIYPSLQG-DGKYHLL-PTGELLIHNLEYNDRYPSYRCRTMHKLTRQVVTSNSAKI 193

  Fly   236 QVKELSKNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTWYRVSDSAALYPIPSSQRVIL 300
            ::.|....::|...:. ...:.|.:.....|.|..||.|.|.:.||..:....: |:.|..|:.|
Mosquito   194 RMNEQRGIVSPSVVEH-TSHVAVSQDEGAVLLCVAQGCPSPEYRWYTHNGPEPI-PVSSGPRIRL 256

  Fly   301 SRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTT 365
            ...:|.|:.....|.|.:.|.|||..||...::||:|::.:.|.|.|.|..|:.||||.|.|..|
Mosquito   257 LGPVLAIEAVTAEDGGVYKCSASNAGGEASADLRLTVSTPIHVEITPNVLSVHMGGTAEFRCLVT 321

  Fly   366 GSAIDA----IDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRA-S 425
            .:.:.|    |.|..:|:.|.     ::||..      .:|.|..|.|.|:|:|||:|..|.. |
Mosquito   322 ANGMSAGPQHITWFKDGRQLP-----SSGRVG------DTLQVTGVTREDKGMYQCVVRRQEGDS 375

  Fly   426 AQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAI 490
            .||.|||:|||..|.|:|:||||.::|||.:||||||.|:|.||.||.||..|:   ..:.||.|
Mosquito   376 FQASAELQLGDAPPSLVYSFIEQTLQPGPAVSLKCSAQGNPTPQIAWTLDGFPL---PTNGRFMI 437

  Fly   491 GQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGED 555
            ||:|.:.||||||:|||||..:|||.|.|.|.|..|...||||||:||.||:|.|..:.||||..
Mosquito   438 GQYVTVHGDVISHVNISHVMVEDGGEYSCAAENRAGKTSHSARLNIYGLPYIRLIPKVTAVAGHT 502

  Fly   556 IIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGE 620
            :.:.||.||||:|:|.||:..:||......::.|   .|.|.||.|:...|.|:|||..|::.|.
Mosquito   503 LYLKCPVAGYPIEEIHWERGGRELPEDMRQKVQS---DGTLEIKEVQKSLDSGVYTCWARNKQGH 564

  Fly   621 EARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSL--QITE 683
            .|||..::.|..||.||||.|...|.||.|.:..|.||.||.|:...|.||...:.|:|  ....
Mosquito   565 SARRSGEVAVIVPPNIEPFSFQDGLAEGMRTRTVCGVSKGDPPLTLKWLKDGDPLLSTLLGANVS 629

  Fly   684 KKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISIN 748
            ..:::.|||....:||.|||.|||.|||.||:|.:||.|||:|.|||..||.|.::.....|.::
Mosquito   630 TLDQYSSLLNIPSLSAAHSGDYTCVASNPAAEVKFTASLQVKVPPRWVVEPTDVSVERNRHIMLH 694

  Fly   749 CEAEGYPIPTITWFKGQGKGSKDFKPLSMR-------NHSLLLNLATDNDEGYYMCQATNEIGAG 806
            |:|:|.|:|||.|.|..|..|.|::.:..|       |.||||....::.||:|:|||.|.||.|
Mosquito   695 CQAQGVPVPTILWKKATGSKSGDYEEVRERPYTKLLANGSLLLQHVKEDREGFYLCQANNGIGTG 759

  Fly   807 LKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLN---NFRFSI 868
            :.|.|::.||....|...::.::.::.|...:.|..|||:||.:.|.: ||:.:||   |:|.||
Mosquito   760 IGKVIQLKVNSSPYFAGQSKMVTVKKGDTAIMQCEVKGDKPINVVWLR-NGKHELNPSTNYRVSI 823

  Fly   869 AEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTV 933
            .:..|.:|:.:::.|.:.|..|||.|.|.|.|.|||.:|::.|.|||.|..||.||...|.||.|
Mosquito   824 KQDATPEGISAEVQISNVDSSDSGAYFCQASNLYGRDQQLVQLQVQEPPQPPSSLEAATVSSRVV 888

  Fly   934 KLSWRRPFDGNSPVLS-YLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRE 997
            .|.| :|..|::..:| |:|:|:.:              |.....|.:|.|.     :|      
Mosquito   889 NLKW-QPRGGDAAEVSKYIVEYREI--------------DRQWQYIEISDPP-----AY------ 927

  Fly   998 SAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQTGGESELIVTWQIP 1062
            |.|:..|.|||.::.|:.|.....||:.::.:.:||..:.|...|.|:..:....:|:::||..|
Mosquito   928 STIIENLKPATNYVFRIIAEGPAGRSSPSQELFIKTDPQRPAGPPLNLGARPISSTEILITWMPP 992

  Fly  1063 PRESWNGELIGYTVNCSEEKQNINFISV--VNSSLKSTIVSG---WATTKATLRGLRKYSRYAVT 1122
            ..|..:||:.||         ||.:.|:  ..:|...|.:||   ..|.:..|..|.||:||.:.
Mosquito   993 SYELRHGEIQGY---------NIGYRSMHATTNSYNFTSISGDGEDGTGELLLGNLAKYTRYTIV 1048

  Fly  1123 IRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFH-GGIIQGYKIL 1186
            .:|.|..|.||.|..:...|.|.||...|:::.|.|.||.|:::|| :||...| .|::||||:.
Mosquito  1049 AQAFNQVGPGPLSEPVTAQTMEDVPSKPPEDIRCMAQSSTSIQVSW-QPPQAHHTNGLLQGYKVF 1112

  Fly  1187 YRPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIRVLAYTATGDGLASHPLFCQTDDDVPDA 1251
            |...........::|.::|::|..:|..|.|.|||||:|||||..|||:.|.|.||.||:|.|:|
Mosquito  1113 YECATEDAISSGEMETRKTTSLTIHLSNLRKFSNYSIQVLAYTRMGDGVISPPSFCHTDEDAPEA 1177

  Fly  1252 PAAIKAAALTADSILISWLTPKNRNGIISHYTVYSREAG---------RKGQAKTHMVRVDENGY 1307
            ||.||.|..:..|:.:|||.|::.||||:.|.:|.|...         |..||..|         
Mosquito  1178 PADIKIAISSPSSLYVSWLPPRDPNGIITKYNLYMRAVNGREELNNDKRNLQAHQH--------- 1233

  Fly  1308 PVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAVGTGLVLEC 1372
              .||::.|..:..|:|||||||.||||:.:.|::|.|:.|.||:|.|||.:..:...:...|.|
Mosquito  1234 --HFEAKQLQSHTEYQFWVSASTRVGEGKSSRVVSQLTSNRVPAKIVSFGGLTIRPWKSSASLNC 1296

  Fly  1373 LAVGNPTPRARWLTRD---RPVTFSPFYEVTNEGNLKIHRVEGSLSGNYTCTANNLFGSDEIQYQ 1434
            :|||.  ||..|...|   ||.| ....::.:.|.:.:..::.|.:|||||..:|..|:|.:.:.
Mosquito  1297 MAVGQ--PRREWFKGDTLLRPGT-QHNIQLLDSGEIIVTMLQTSDTGNYTCQVDNGIGTDRLTHN 1358

  Fly  1435 VIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTISYHTAGESWSITELLPENNAFTIS 1499
            ::...||..|.:.|..|::.||.:.|.....|.||:..:::.|.....:....:|....::..:.
Mosquito  1359 LLVQVPPGPPVLYVTSATSSSILLHWKIGSTGNAPITAFSLHYRRVHGNLEEMQLSRHASSHDLK 1423

  Fly  1500 GLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSSWQNGGCS 1564
            ||.||:.|.:.:.|||.:||..||..:||.|:|:....|..:.|||.|:|.|.|:|:.|.:.||.
Mosquito  1424 GLFCGSTYQVYLVAHNKIGSSSASTTLNVKTQGQPPGIPPDSVLIAPNSTSVVLRLNGWPDNGCP 1488

  Fly  1565 IHHFSIEHRPLG---DIRWTVVTSDISNAEENRENLIFCDFLPAKWYQLRISATNDAGKTTEHYH 1626
            |.:|.:::|.:.   |..|.:|    |||.:.:........||:..|:|::.|.|.||.|...|.
Mosquito  1489 IMYFVLQYRSVSTGLDDEWHLV----SNALKPQRRFTLSGLLPSTMYRLKMEAHNVAGSTNAEYT 1549

  Fly  1627 FSTTNIDGITIPPPSVFP--SENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTI---K 1686
            |.|...|| ..|||.:..  ..:.:..|.|....|          :::.||.:||.||.|:   |
Mosquito  1550 FWTLTKDG-DPPPPELVQRGHRSQIFYNNIQLLIP----------IIITITATIICIAFTVVCYK 1603

  Fly  1687 HRRTLCGPIAEGYESR----TLPGDYKEDHENRRNQQVYSASPVKTVDKGNESEMYEISPYATFS 1747
            :..|..  ...|...|    |:......|.:..|.........::..||..|:. .:|||||||.
Mosquito  1604 YPNTFY--FVTGQRGRQRKDTMESQQTTDAQRDRYYATIHKVALQAGDKIPETS-EDISPYATFQ 1665

  Fly  1748 VNGGRT------GAPAKT-----------PTRAVAAQTPLDYTMQ------FKTFGHPEGENLNA 1789
            ::...|      ..||.|           .|...|:..|...:.:      .||  .||.|..::
Mosquito  1666 LSEASTLAQPHHSGPANTLLHSFMYHERAMTEGCASPPPAANSSKGRRRHSRKT--EPESEESDS 1728

  Fly  1790 TAYPLLPSSGFGHVKSKSSWHKQRYYNTEDESTL------SKSMTIVAGSQAGHSKKSNGGRSAK 1848
            ....|..|                  .||..:.|      ||.:.:.||....|....|     .
Mosquito  1729 DPDQLTSS------------------RTESSNQLDAKMKHSKDLDVAAGGPGDHGYNPN-----H 1770

  Fly  1849 SSAACSGVV-AGSESDTS--ISPSTEFSNMP--------------TYRVPCKSSRSSDGRAVVDM 1896
            ...:..|:: .|::|.||  :||.:|..::|              |...|    |....:|...:
Mosquito  1771 YMRSIPGLIYHGTQSSTSSDLSPMSEQKSLPRRGRSRYHHLHLHNTNTTP----RHKSSKAQSPI 1831

  Fly  1897 FRPDSSTESNN 1907
            ..|.||.:::|
Mosquito  1832 ASPRSSCQNDN 1842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 35/76 (46%)
Ig 56..125 CDD:143165 30/68 (44%)
I-set 246..337 CDD:254352 26/90 (29%)
Ig 264..334 CDD:143165 22/69 (32%)
I-set 345..433 CDD:254352 34/92 (37%)
Ig 358..431 CDD:143165 25/77 (32%)
Ig 456..533 CDD:143165 42/76 (55%)
IGc2 553..619 CDD:197706 25/65 (38%)
I-set 634..724 CDD:254352 41/91 (45%)
ig 645..712 CDD:278476 28/68 (41%)
IG_like 734..815 CDD:214653 33/87 (38%)
Ig 745..815 CDD:299845 31/76 (41%)
I-set 820..913 CDD:254352 33/95 (35%)
Ig 838..920 CDD:299845 35/84 (42%)
FN3 917..1033 CDD:238020 32/116 (28%)
FN3 1040..1142 CDD:238020 31/106 (29%)
fn3 1150..1237 CDD:278470 36/87 (41%)
FN3 1263..1345 CDD:238020 33/90 (37%)
Ig 1350..1436 CDD:299845 28/88 (32%)
IG_like 1358..1436 CDD:214653 22/80 (28%)
FN3 1441..1530 CDD:238020 26/88 (30%)
FN3 1542..1620 CDD:238020 27/80 (34%)
AgaP_AGAP004902XP_001688600.1 Ig <17..88 CDD:299845 32/70 (46%)
I-set 204..293 CDD:254352 26/90 (29%)
Ig 222..293 CDD:299845 24/71 (34%)
I-set 298..383 CDD:254352 35/95 (37%)
IGc2 310..369 CDD:197706 23/69 (33%)
IG_like 398..483 CDD:214653 49/87 (56%)
IGc2 402..473 CDD:197706 42/73 (58%)
IG_like 493..576 CDD:214653 33/85 (39%)
IGc2 500..563 CDD:197706 25/65 (38%)
I-set 572..670 CDD:254352 43/97 (44%)
Ig 598..667 CDD:143165 29/68 (43%)
IG_like 680..768 CDD:214653 33/87 (38%)
Ig 691..768 CDD:299845 31/76 (41%)
I-set 772..860 CDD:254352 30/88 (34%)
Ig 786..875 CDD:299845 36/89 (40%)
FN3 872..963 CDD:238020 32/116 (28%)
FN3 970..1068 CDD:238020 31/106 (29%)
FN3 1076..1170 CDD:238020 40/94 (43%)
FN3 1175..1269 CDD:238020 40/104 (38%)
Ig 1292..1362 CDD:299845 22/72 (31%)
FN3 1364..1454 CDD:238020 27/89 (30%)
FN3 1459..1542 CDD:238020 27/86 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47134
OrthoDB 1 1.010 - - D10185at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.930

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