DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and AgaP_AGAP008778

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_314904.3	Gene:	AgaP_AGAP008778 / 1275637	VectorBaseID:	AGAP008778	Length:	241	Species:	Anopheles gambiae

Alignment Length:	303	Identity:	69/303 - (22%)
Similarity:	109/303 - (35%)	Gaps:	78/303 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 PIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVH--ILPQVQIVN 353
            |||:. .|.:.|..||            .|...|..|.:...:|:...:.:|:|  ::.|    |
Mosquito     6 PIPNI-TVTIGRDALL------------ACVVDNLKGYKVAWVRVDTQTILSIHHNVITQ----N 53

  Fly   354 SGGTANFNCTTTGSAIDAIDW-LHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQC 417
            ...:..:|        |...| ||                           ::.|...|||.|.|
Mosquito    54 PRISLTYN--------DHRSWYLH---------------------------IREVEESDRGWYMC 83

  Fly   418 LVENQRASAQAMAELK--LGDTVPELIYTFIEQN---VRPGPLISLKCSASGSPPPQFAWLLDSQ 477
            .|     :...|...|  |...||..|...:..|   ||.|..::|.|.|.|.|.|...|..:..
Mosquito    84 QV-----NTDPMRSRKGYLQVVVPPAIIESMTSNDMVVREGTNVTLNCKAKGFPEPYVMWRREDG 143

  Fly   478 PIMDVSLHHRFAIGQFVD-MSGDVISHLNISHVRPDDGGLYKCVASNSM-GSVQHSARLNVYGPP 540
            ..|.:|       |:.|: :.|:::....:|.:..   ..|.|||||.: .|:....:|.|..||
Mosquito   144 DEMAIS-------GENVNVVDGEILHITKVSRLHM---AAYLCVASNGVPPSISKRVQLRVQFPP 198

  Fly   541 YVRAIGPIK-AVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTS 582
            .:.....:: |..|:|:::.|....||.....|.....::..|
Mosquito   199 MLSIPNQLEGAYVGQDVVLECHTEAYPASINYWTTERGDMIIS 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	11/45 (24%)
		Ig	264..334	CDD:143165	10/42 (24%)
		I-set	345..433	CDD:254352	15/88 (17%)
		Ig	358..431	CDD:143165	13/73 (18%)
		Ig	456..533	CDD:143165	20/78 (26%)
		IGc2	553..619	CDD:197706	7/30 (23%)
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP008778	XP_314904.3	IG_like	8..101	CDD:214653	28/149 (19%)
		Ig	9..99	CDD:299845	27/146 (18%)
		IG_like	111..194	CDD:214653	25/92 (27%)
		IGc2	118..182	CDD:197706	20/73 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810