DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP008734

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_314848.4	Gene:	AgaP_AGAP008734 / 1275587	VectorBaseID:	AGAP008734	Length:	292	Species:	Anopheles gambiae

Alignment Length:	370	Identity:	64/370 - (17%)
Similarity:	122/370 - (32%)	Gaps:	142/370 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 GGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGR-----------DNIRFLSKSSLLVQNVG 408
            ||||...||....:...:.|:..    |....||.|.           :::|.|...:|.:::|.
Mosquito    16 GGTALLPCTVISQSSALVSWIRR----QDFQLLTVGLATYSSDERFLVEHLRHLGHWALRIKSVR 76

  Fly   409 RRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCS-ASGSPPPQFAW 472
            ..|.|:|:|.:......: ...|||:.:.|.|::.. .:.::..|..:.|:|. .|.:..|.|.:
Mosquito    77 TEDEGLYECQLSVHPVQS-VFVELKVVEAVAEIVGA-PDLHIDEGSTLRLECKLQSATENPTFVF 139

  Fly   473 LLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVY 537
            ....|.:::.                |.::..:::..:|.             .:..|.:.|:.|
Mosquito   140 WYHEQNMVNF----------------DQLNGFSVTPFQPP-------------ATASHPSHLHPY 175

  Fly   538 GPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVE 602
            ..|                        :|:|    :..|:....|:..:..::.|..:|:.::::
Mosquito   176 LFP------------------------HPLE----DDQHELPELSSEEQGYNLLDDDRLLQRSLK 212

  Fly   603 PGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFS 667
            .|:|..                            |||..|
Mosquito   213 LGQDSA----------------------------EPFLTP------------------------- 224

  Fly   668 WKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNA 712
                  |..|||.:        ::|..|::..||:|.|||..|||
Mosquito   225 ------SSSSSLLL--------AVLTIKEVHLRHAGNYTCAPSNA 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	20/88 (23%)
		Ig	358..431	CDD:143165	16/83 (19%)
		Ig	456..533	CDD:143165	9/77 (12%)
		IGc2	553..619	CDD:197706	8/65 (12%)
		I-set	634..724	CDD:254352	19/79 (24%)
		ig	645..712	CDD:278476	13/66 (20%)
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP008734	XP_314848.4	V-set	6..102	CDD:284989	22/90 (24%)
		IG_like	11..101	CDD:214653	21/89 (24%)
		IG_like	<233..264	CDD:214653	11/23 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810