DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP012441

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_313213.4	Gene:	AgaP_AGAP012441 / 1274136	VectorBaseID:	AGAP012441	Length:	268	Species:	Anopheles gambiae

Alignment Length:	300	Identity:	74/300 - (24%)
Similarity:	102/300 - (34%)	Gaps:	98/300 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 GNDVHLPCNIQGNPFPIFTWYRVSD----SAALYPIPSSQRVILSRT--------LLLIKNADER 313
            |:..|:||.|......:.:|.|..|    :..|....|.:|  .|.|        .|.||...:|
Mosquito    18 GSTAHVPCRIHHIGEGVVSWIRRKDYHLLTVGLTTYSSDER--FSATHLQNSEDWTLQIKFVQDR 80

  Fly   314 DAGKWICQASNQ-----FGEQR-IEIRLSVNSYVSVHILPQVQIVNSGGTANFNC----TTTGSA 368
            |||.:.||.|..     |.|.: :|.|..:       :.|||:.:....|....|    :|..||
Mosquito    81 DAGLYECQVSTHPPTSIFLELKVVEARAEI-------VGPQVKYLTPDSTLKLICRVVQSTEASA 138

  Fly   369 IDAIDWLHNGKPLQANNAL------------TTGRDNIRFLSKSSLLVQNVGRRDR--GVYQCLV 419
            .  |.|.||.:.:  |..|            ||.:..:|||..:   :.|:..|.:  ||..||.
Mosquito   139 F--IFWYHNNRMI--NYDLDRGINVSTEAEETTVQFGMRFLFDT---ISNIMLRSQADGVSSCLF 196

  Fly   420 ENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSL 484
            .:.                       ..|:|..| ..||......|.|.       |||:.....
Mosquito   197 RSG-----------------------FGQHVAYG-TESLHVYGLYSTPL-------SQPLALKDF 230

  Fly   485 HHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNS 524
            |:               |.|.||....:..|.|.||.|||
Mosquito   231 HY---------------SELTISQASKEHSGNYTCVPSNS 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352	27/93 (29%)
		Ig	264..334	CDD:143165	25/87 (29%)
		I-set	345..433	CDD:254352	25/105 (24%)
		Ig	358..431	CDD:143165	21/90 (23%)
		Ig	456..533	CDD:143165	18/68 (26%)
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP012441	XP_313213.4	Ig	13..94	CDD:299845	23/77 (30%)
		IG_like	13..90	CDD:214653	22/73 (30%)
		Ig	<233..255	CDD:299845	9/21 (43%)
		IG_like	<233..255	CDD:214653	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810