DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP003141

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_003436405.1	Gene:	AgaP_AGAP003141 / 1273815	VectorBaseID:	AGAP003141	Length:	299	Species:	Anopheles gambiae

Alignment Length:	338	Identity:	70/338 - (20%)
Similarity:	114/338 - (33%)	Gaps:	128/338 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 ASNSMGSVQHSARLNVYGPPYVRAIGP------------IKAVAGEDIIVHCPFAGYPVEQIRWE 573
            :|:|.|:|..||..:|.|....|||.|            :..:.|..:.:.|...|.|...::|
Mosquito    46 SSSSSGTVVSSAEGSVRGGDGGRAIRPTFVKITAAPPARVAQIRGTTVELECEIMGSPTPTVQW- 109

  Fly   574 KAHQELTTSNHYELA----------SVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQL 628
             .|....|::..:::          |||.....::.:......|..:|||.|: ||:|
Mosquito   110 -VHGSGQTADWEDISVNVISEDTPTSVARVVTRLVIDRASRASQTTFTCIGRA-AGQE------- 165

  Fly   629 NVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLV 693
                                        |||                              |.:|
Mosquito   166 ----------------------------VSS------------------------------STVV 172

  Fly   694 FKDISARHSGKY-------------TCYASNAAAKV--NYTAELQVRVAPRWRYEPMDTAIMLGN 743
            :...|..|.|.|             |.:.:..||::  :|          :..:|.|      |:
Mosquito   173 YHVDSVAHLGNYSDVPLLRPVAAVDTMFKNLKAARITLHY----------KTLFENM------GS 221

  Fly   744 TISINCEAEGYPIPTITWFKGQGK--GS-KDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGA 805
            |:.:.|:|.|.|:|.|||...:|.  || :|.:..::....|::......|.|.|.|.|.|.:..
Mosquito   222 TVVLPCKAVGRPLPEITWLNEEGNVVGSLQDARFRTLPTGELIITGLRWADMGSYTCVAKNVLAK 286

  Fly   806 GLKKT----IRIN 814
            ...:|    ||.|
Mosquito   287 DESETFVYPIRPN 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	5/11 (45%)
		IGc2	553..619	CDD:197706	15/75 (20%)
		I-set	634..724	CDD:254352	13/104 (13%)
		ig	645..712	CDD:278476	10/79 (13%)
		IG_like	734..815	CDD:214653	26/88 (30%)
		Ig	745..815	CDD:299845	23/77 (30%)
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP003141	XP_003436405.1	I-set	72..172	CDD:254352	23/167 (14%)
		Ig	93..171	CDD:143165	21/145 (14%)
		IG_like	220..294	CDD:214653	22/73 (30%)
		Ig	223..291	CDD:143165	19/67 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910