DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and AgaP_AGAP010970

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_309724.3	Gene:	AgaP_AGAP010970 / 1270986	VectorBaseID:	AGAP010970	Length:	726	Species:	Anopheles gambiae

Alignment Length:	851	Identity:	197/851 - (23%)
Similarity:	314/851 - (36%)	Gaps:	205/851 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 ISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCV 520
            ::|.|.|.|.|.|...|..|.:|:       :|.....:..:|.:.....:...:.:|.|:|:||
Mosquito    18 VTLNCKADGKPDPAIHWYKDGEPV-------KFTPNHVLLPTGSLFFLRTLHSKKENDAGVYRCV 75

  Fly   521 ASNSMGSVQ-HSARLNVYGPPYVR---AIGP--IKAVAGEDIIVHC--PFAGYPVEQIRWEKAHQ 577
            |||..|..: .:|.|.:   ..:|   .:.|  .:..|||..::.|  | .|.|...|||.|...
Mosquito    76 ASNLAGIAESRNATLQI---ALLRDDFRVEPKDTRVAAGETALLECGAP-KGSPEPGIRWLKDDV 136

  Fly   578 ELTTSNHYELAS------VADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVI 636
            .|....:...|.      :.|||.|:|.:|. ..|.|.|.|...:.||:......:|.|...|..
Mosquito   137 RLVLDENLRSAKEIGRIRIVDGGNLLISDVR-ATDGGRYQCEAFNAAGKRVSSIARLIVQVKPYF 200

  Fly   637 EPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARH 701
            :..........|.|.|..||| .||......|.|::..||  :...|.:||....||.:.:....
Mosquito   201 KLEPMDTTALVGQRVQFRCAV-DGDPTPQILWSKENGHIP--VGRAEIQEEEDRSLVIRSVVPTD 262

  Fly   702 SGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQG 766
            .|.|.|.|.|:..:::..|:|.|...|.:..:|.|....|....|..|.|.|.|.|::.|.|
Mosquito   263 QGMYICEAHNSIGQISAKAQLIVNSPPTFLIKPQDQKTALNGVASFKCTASGNPQPSVFWTK--- 324

  Fly   767 KGSK---------DFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKT-IRINVNE---- 817
            :||:         |...:|::. :|.:.....:|:|||:|.|.:..|:.:.:. :::..:|
Mosquito   325 EGSQTLMFPNNTYDNMQVSVQG-TLQIRGVQKDDDGYYICSALSVAGSTVSRAYLQVLTSEDSSP 388

  Fly   818 PARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLN--NFRFSIAEMKTEKGVDSQ 880
            |...:....|.:..|....||.|.|.|:....|.|.:|...|:|:  |.|.||.:..|
Mosquito   389 PPILQIVPANQTLPRGTVATLPCRASGNPTPMIRWMKNATDINLSGGNGRISIIQGGT------- 446

  Fly   881 LTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNS 945
            |.|......|||.|||:              |..|:.:|
Mosquito   447 LRIDDLRNEDSGWYRCV--------------AFSEKGET-------------------------- 471

  Fly   946 PVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSIS---RSYDSDLRESAIVAGLTPA 1007
                                      .|:.|:...|....|::   ||::::|..||  .|:..|
Mosquito   472 --------------------------SWSAHLTVSSFLWCSVACFHRSHNAELLPSA--PGMPKA 508

  Fly  1008 TTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQ-TGGESELIVTWQIPPRESWNGEL 1071
            ...                              ..||:.:. |.|:.||          ..|...
Mosquito   509 VNI------------------------------TNSNITLTWTRGQDEL----------QMNSVT 533

  Fly  1072 IGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYAVTIRAMNSFG---SGP 1133
            .|||:.....::...:|..::.      :.|:.   ||:..|...:.|...|||.|.:|   ..|
Mosquito   534 DGYTIEYYSPEEKAGWIKAMSR------IPGYT---ATITNLSPSTSYMFIIRAENGYGYSAPSP 589

  Fly  1134 WSAAIFGTTA-EGV--PEAAP-----------QNVNCTALSSQSLKISWLEPPLQFH----GGII 1180
            .||.|...:| :||  ||...           :.|:..|::|.::::.|     |.|    ...:
Mosquito   590 TSAIIRTLSANDGVTMPEEIETARLLLSGQILELVDAVAINSTTIRLEW-----QLHISNTNDYV 649

  Fly  1181 QGYKILYRPIVHQIDFPAKLEIKRTSN-LETYLHT-LHKASNYSIRVLAYTATGDGLASHPLFCQ 1243
            :|..:.||.:....|..:...:....| .|||:.| |.|.:.|...:..|..|.:|..:.....|
Mosquito   650 EGLYVRYRNLSAGADAQSYSMLTIPMNPSETYVITGLEKFTRYEFFLTPYFKTVEGQPTSSKVVQ 714

  Fly  1244 TDDDVP 1249
            |.:|.|
Mosquito   715 TLEDFP 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	20/77 (26%)
		IGc2	553..619	CDD:197706	22/73 (30%)
		I-set	634..724	CDD:254352	25/89 (28%)
		ig	645..712	CDD:278476	21/66 (32%)
		IG_like	734..815	CDD:214653	23/90 (26%)
		Ig	745..815	CDD:299845	20/79 (25%)
		I-set	820..913	CDD:254352	25/94 (27%)
		Ig	838..920	CDD:299845	24/83 (29%)
		FN3	917..1033	CDD:238020	12/118 (10%)
		FN3	1040..1142	CDD:238020	25/105 (24%)
		fn3	1150..1237	CDD:278470	21/103 (20%)
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP010970	XP_309724.3	Ig	1..93	CDD:299845	22/84 (26%)
		I-set	1..92	CDD:254352	22/80 (28%)
		I-set	99..194	CDD:254352	27/96 (28%)
		Ig	101..194	CDD:299845	27/94 (29%)
		I-set	198..285	CDD:254352	25/89 (28%)
		Ig	215..285	CDD:299845	22/72 (31%)
		I-set	289..380	CDD:254352	24/94 (26%)
		Ig	306..389	CDD:299845	21/86 (24%)
		IG_like	396..479	CDD:214653	30/155 (19%)
		Ig	407..476	CDD:143165	27/141 (19%)
		FN3	500..594	CDD:238020	28/144 (19%)
		FN3	624..715	CDD:238020	21/95 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910