DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and AgaP_AGAP007500

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_308376.4	Gene:	AgaP_AGAP007500 / 1269727	VectorBaseID:	AGAP007500	Length:	383	Species:	Anopheles gambiae

Alignment Length:	317	Identity:	84/317 - (26%)
Similarity:	136/317 - (42%)	Gaps:	29/317 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 SVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTG--------RDNIRF-L 397
            ::..:.|.||.:.|||....|:...::..::.|:...........|:||        |.::|: |
Mosquito    37 TISYITQEQIKDIGGTVELECSVLYASDYSVHWVKTSNDRSDTVFLSTGSSLVLKDSRFSLRYDL 101

  Fly   398 SKSS--LLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQN--VRPGPLISL 458
            |.:|  |.::::...|.|:|||.|. ...:.:..||:.|....|.:|.....|:  |..|....:
Mosquito   102 SSTSYTLQIKDIQETDAGIYQCQVV-LSVTNKISAEVALNVRRPPIISDNSTQSLVVSEGQPAQM 165

  Fly   459 KCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASN 523
            :|.|||.|.||..|..::..|:...   ....|.....||:|   |||..|..:|.|.|.|||.|
Mosquito   166 ECYASGYPVPQITWRRENNAILPTG---NDGGGGGATYSGNV---LNIHSVHKEDRGTYYCVADN 224

  Fly   524 --SMGSVQHSARLNVYGPPYVRAIGP-IKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHY 585
              |.|. :.:..|.|...|.|....| ::.....|:.:.|....||...|||.|...:|:::.||
Mosquito   225 GVSRGD-RRNVNLEVEFAPVVTVPRPRVEQALQYDMDLECHIEAYPPPAIRWLKDSVQLSSNQHY 288

  Fly   586 ELASVADGGQLVIKNVE----PGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEP 638
            :|:..|...:.....:.    ..|..|.|.|...::.|:...| ::...:..||..|
Mosquito   289 QLSQFATADEFTDSTLRVITAEKRQYGEYICQATNKLGDAEGR-VEFTESVIPVCPP 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352	25/98 (26%)
		Ig	358..431	CDD:143165	17/83 (20%)
		Ig	456..533	CDD:143165	26/78 (33%)
		IGc2	553..619	CDD:197706	17/69 (25%)
		I-set	634..724	CDD:254352	3/5 (60%)
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
AgaP_AGAP007500	XP_308376.4	IG_like	43..141	CDD:214653	26/98 (27%)
		V-set	50..142	CDD:284989	23/92 (25%)
		IG_like	153..238	CDD:214653	30/91 (33%)
		IGc2	159..227	CDD:197706	25/73 (34%)
		I-set	242..335	CDD:254352	22/93 (24%)
		IGc2	261..326	CDD:197706	16/64 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810