DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and CHL1

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:NP_006605.2 Gene:CHL1 / 10752 HGNCID:1939 Length:1224 Species:Homo sapiens


Alignment Length:1413 Identity:292/1413 - (20%)
Similarity:485/1413 - (34%) Gaps:455/1413 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LEPPCLVLEKALLLGALLLAVLATPLL--------ATSGLRVPTFLLEPAPRLLFGNDTGAQVTC 60
            :||        ||||..|:..|...||        .:|..:|||.:.:...::.|..|...|:.|
Human     1 MEP--------LLLGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQVAFPFDEYFQIEC 57

  Fly    61 TAHGSPPPLVTWVLRDGS---------LATQVPGLRKISGNGTL-HFPPFLAQYYRTDVHEATYR 115
            .|.|:|.|..:|. :||:         :.:...|..:|...|.: ||             :..||
Human    58 EAKGNPEPTFSWT-KDGNPFYFTDHRIIPSNNSGTFRIPNEGHISHF-------------QGKYR 108

  Fly   116 CRASNEAGTVLSRNVQ-VHAVVRRQFHVHVENTEVYLGNSALIKCAIPEYVRP----YVRVASWH 175
            |.|||:.|..:|..:: :...|.:.....::..||..|:..::.|..|:.:.|    ::.:...|
Human   109 CFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHIYWMNIELEH 173

  Fly   176 RGEEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSC-----------------LVTNTL 223
            ..::           ..|.::..||||..:|..:|....:.|                 |..|:|
Human   174 IEQD-----------ERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTVNSL 227

  Fly   224 NGERQRSDAVMLQVKELS------KNLAPRTTQKPVMEIHVERGNDVHLPCNIQGNPFPIFTWYR 282
            ......|.:..:..|..|      |.|.|.|.......|.:.:|..:.|.|..:|.|.|...|.:
Human   228 KHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNK 292

  Fly   283 VSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILP 347
            :...   .|.....:....:| |.|:|...:|.|.:.|.|||..|....:.      :|.|...|
Human   293 IGGD---LPKGRETKENYGKT-LKIENVSYQDKGNYRCTASNFLGTATHDF------HVIVEEPP 347

  Fly   348 QVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDR 412
            :                         |  ..||..|  ..:||.:.|                  
Human   348 R-------------------------W--TKKPQSA--VYSTGSNGI------------------ 365

  Fly   413 GVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQ 477
                                                         |.|.|.|.|.|...|.::..
Human   366 ---------------------------------------------LLCEAEGEPQPTIKWRVNGS 385

  Fly   478 PIMDVSLHHRFAIGQFVDMSGDVI--SHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPP 540
            |:.    :|.||        |||:  ..::.::::|:...:|:|.|||..|::..:|.::|..  
Human   386 PVD----NHPFA--------GDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVD-- 436

  Fly   541 YVRAIGPIK------AVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIK 599
             ||.:...|      .|.|....:||.|...|...:.|:|..:                    :|
Human   437 -VRPLIQTKDGENYATVVGYSAFLHCEFFASPEAVVSWQKVEE--------------------VK 480

  Fly   600 NVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPI 664
            .:| ||...||                                    |.|               
Human   481 PLE-GRRYHIY------------------------------------ENG--------------- 493

  Fly   665 YFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPR 729
                         :|||....||             .:|.|:|:..||..|...||.|.:|.|.:
Human   494 -------------TLQINRTTEE-------------DAGSYSCWVENAIGKTAVTANLDIRNATK 532

  Fly   730 WRYEPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGY 794
            .|..|.:..|...:.:.::||:                     |..|...|||.|:.:.|.:   
Human   533 LRVSPKNPRIPKLHMLELHCES---------------------KCDSHLKHSLKLSWSKDGE--- 573

  Fly   795 YMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRI 859
                           ...||..|                                      :|||
Human   574 ---------------AFEINGTE--------------------------------------DGRI 585

  Fly   860 DLNNFRFSIAEMKTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLE 924
            .::.               :.|||.:....|.|:|.|.|......|..|..:.|.:.||.|.:|.
Human   586 IIDG---------------ANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPENLH 635

  Fly   925 IFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISR 989
            :.|..:|:|:|:|....|.||.:..|:|:::..|         ...|.|.           .::|
Human   636 LSERQNRSVRLTWEAGADHNSNISEYIVEFEGNK---------EEPGRWE-----------ELTR 680

  Fly   990 SYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTE-AIVLKTQEEAPTEAPSNVQVQTGGES 1053
            ...   :::.::..|.|...:..|:.|:||:.||..:: :...:|...||...|.|::||.....
Human   681 VQG---KKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPK 742

  Fly  1054 ELIVTWQIPPRESWNGELIGYTVNCSEEKQNINF--ISVVNSSLKSTIVSGWATTKATLRGLRKY 1116
            |:|:.|:.......||..:.|.|....:...:.:  .:|.|.:|:       ..|.|.      |
Human   743 EMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLR-------VMTPAV------Y 794

  Fly  1117 SRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQ 1181
            :.|.|.::|:|..||||...::...:.|..|:.||.......::|..:|::|...|.....|.::
Human   795 APYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLK 859

  Fly  1182 GYKILYRPIVHQID---FPAKLEIKRTSNLET--YLHTLHKASNYSIRVLAYTATGDGLASHPLF 1241
            ||:|.:......:|   .|.::.|.|.|....  .:.:|...|.:.:.||||.:.|.|..|.|..
Human   860 GYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYI 924

  Fly  1242 CQTDDDVPDAPAAIKAAALTADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDE-N 1305
            .||.:.||:.|..:|...:..|:..:||..||..||.::.|.:       :.|.......:.| |
Human   925 FQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLL-------QYQIINDTYEIGELN 982

  Fly  1306 GYPVTFESR------SLAENQMYEFWVSASTSVGEGEPTSVIAQATNT 1347
            ...:|..|:      :|.....|:|::.|.||.|.|:|   |.:.::|
Human   983 DINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKP---ITEESST 1027

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652 22/87 (25%)
Ig 56..125 CDD:143165 21/78 (27%)
I-set 246..337 CDD:254352 22/90 (24%)
Ig 264..334 CDD:143165 18/69 (26%)
I-set 345..433 CDD:254352 8/87 (9%)
Ig 358..431 CDD:143165 7/72 (10%)
Ig 456..533 CDD:143165 21/78 (27%)
IGc2 553..619 CDD:197706 13/65 (20%)
I-set 634..724 CDD:254352 16/89 (18%)
ig 645..712 CDD:278476 10/66 (15%)
IG_like 734..815 CDD:214653 12/80 (15%)
Ig 745..815 CDD:299845 10/69 (14%)
I-set 820..913 CDD:254352 13/92 (14%)
Ig 838..920 CDD:299845 16/81 (20%)
FN3 917..1033 CDD:238020 26/116 (22%)
FN3 1040..1142 CDD:238020 25/103 (24%)
fn3 1150..1237 CDD:278470 23/91 (25%)
FN3 1263..1345 CDD:238020 23/88 (26%)
Ig 1350..1436 CDD:299845
IG_like 1358..1436 CDD:214653
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
CHL1NP_006605.2 Ig 55..126 CDD:299845 21/84 (25%)
Ig2_L1-CAM_like 129..223 CDD:143253 16/104 (15%)
IG_like 140..224 CDD:214653 16/94 (17%)
IG_like 264..343 CDD:214653 21/88 (24%)
Ig3_L1-CAM_like 274..344 CDD:143208 19/79 (24%)
IG_like 353..434 CDD:214653 27/157 (17%)
Ig4_L1-NrCAM_like 361..435 CDD:143179 24/148 (16%)
IG_like 447..525 CDD:214653 29/175 (17%)
Ig 457..525 CDD:299845 27/165 (16%)
IG_like 548..624 CDD:214653 25/167 (15%)
Ig 548..616 CDD:143165 23/159 (14%)
DGEA 571..574 1/20 (5%)
FN3 628..717 CDD:238020 26/111 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..732 5/22 (23%)
fn3 731..811 CDD:278470 23/92 (25%)
FN3 834..927 CDD:238020 23/92 (25%)
FN3 932..1027 CDD:238020 26/104 (25%)
Bravo_FIGEY 1120..1205 CDD:290593
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1147..1179
FIG[AQ]Y 1197..1201
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1205..1224
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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