DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam3 and npffr1.1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_004915843.2	Gene:	npffr1.1 / 101733377	XenbaseID:	XB-GENE-987767	Length:	430	Species:	Xenopus tropicalis

Alignment Length:	313	Identity:	63/313 - (20%)
Similarity:	98/313 - (31%)	Gaps:	79/313 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1621 TTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVVVIITVSIITIALTI 1685
            |.:.:||...:.:.. .|..|.:....|.....|.:|...|..:.|.|.::||:...|     ..
Frog   178 TKDDFHFMVDDYNNY-YPLYSCWEEWPDTEMRKIYTTVLFSHIYLAPLTLIVIMYARI-----AF 236

  Fly  1686 KHRRTLCGPIAEGYESRTLPGDYKEDHENRRNQQVYSASPVKTVDKGNESEMYEISPYATFSVNG 1750
            |..::          |..:.|...|::|.||            |.|.....:|.:...|.|
Frog   237 KLFKS----------SAPIRGSVSEENEGRR------------VSKRKVRVIYMLIIVALF---- 275

  Fly  1751 GRTGAPAKTPTRAVAAQTPLDYTMQFKTFGHPEGENLNATAYPLLPSSGFGH----VKSKSSWHK 1811
                        ...:..||...|....:||.....||..|..:.|   |.|    ..|..:...
Frog   276 ------------FSLSWLPLWTLMLLTDYGHLSDYQLNLIAVYVFP---FAHWLAFFNSSVNPII 325

  Fly  1812 QRYYNTEDESTLSKSMTIVAGSQAGHSKKSNGGRSAKSSAACSGV-------------VAGSESD 1863
            ..|:|........::..:...|.....:::...|  |:|....||             ..||:|.
Frog   326 YGYFNENFRRGFQEAFKVQVCSMKREHRETYSER--KNSGFLFGVRNRIFVEVQPSDSGQGSDSC 388

  Fly  1864 TSISPSTEFSNMPTYRVPCKSSR-SSDGRAVVDMFRPDSSTESNNDQGSPAPE 1915
            .|.:....||        .:|.| :..|..|.|:    .:..|||....||.|
Frog   389 NSTAKGGMFS--------LRSGRIAHHGLVVEDV----DNKSSNNTVSVPAWE 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352
		ig	645..712	CDD:278476
		IG_like	734..815	CDD:214653
		Ig	745..815	CDD:299845
		I-set	820..913	CDD:254352
		Ig	838..920	CDD:299845
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
npffr1.1	XP_004915843.2	7tmA_NPFFR1	39..337	CDD:320647	40/205 (20%)
		TM helix 1	41..65	CDD:320647
		TM helix 2	74..96	CDD:320647
		TM helix 3	112..134	CDD:320647
		TM helix 4	155..171	CDD:320647
		TM helix 5	209..232	CDD:320647	7/22 (32%)
		TM helix 6	266..288	CDD:320647	5/37 (14%)
		TM helix 7	305..330	CDD:320647	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910