DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and mag

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_004916459.1	Gene:	mag / 100494147	XenbaseID:	XB-GENE-6462484	Length:	625	Species:	Xenopus tropicalis

Alignment Length:	522	Identity:	113/522 - (21%)
Similarity:	189/522 - (36%)	Gaps:	129/522 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   637 EPF-KFPKNLQEGGRAQITCAVSSG--DMPIYFSWKK----DDSSIPSSLQITEKKEEFYSLLVF 694
            ||| ..|:.:..|..|::||.|...  ||....:|.:    :..|:..||:  |.:..:..:...
Frog   141 EPFVSLPQEMVSGSEAELTCRVPDNCPDMKPSVNWMEIEGLEHHSVYGSLE--ESRSTWTQVSTL 203

  Fly   695 KDI-SARHSG-KYTCYASNAAAKVNYT--AELQVRVAPR-----WRYEPMDTAIMLGNTISINCE 750
            |.| |.:::| :.:|..|...|.:.|.  ..:.|:.|||     ..:|..:     |..:...|.
Frog   204 KFIPSYKNNGQRLSCKVSFPGADMEYKGFVTMNVKYAPRIVDINSSFETTE-----GTQVVFVCV 263

  Fly   751 AEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINV 815
            .:..|:..:.|:|......:|.    ..|.:|.|...|.|.:|.|:|.|.||.|. ..||:.:.|
Frog   264 VDSNPVSRVGWYKEGALIREDV----TGNLTLELEYVTFNHDGIYVCAAENEYGR-TNKTMGLAV 323

  Fly   816 NEPARFEQSARNISSRRNDPVTLDCHAKGD-EPITIGWTQNNGRIDLNNFRFSIAEMKTEKGVDS 879
            ..|........::::...:.:|:.|:.:|: :||                   |:.:|.::.:.|
Frog   324 MYPPWKPSVNASVTAMEGETITILCNTQGNPDPI-------------------ISIVKDKQVLTS 369

  Fly   880 QL----------TIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTPSHLEIFEVGSR--- 931
            .:          .|.|  .|| |.|.|.|||.||::.....|.|...|     |.:.|  |:
Frog   370 VIFENEAVFEIPAITH--EHD-GEYWCTAENQYGQSNSSFNLTVVFSP-----LVLLE--SKCTV 424

  Fly   932 ---------TVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWNGHVINV------- 980
                     |||.         :|....|.:...:....|.|.........||::::.
Frog   425 SKDTVQCMCTVKA---------NPEPYILFELPEMNLTVSEGDPEFVYSQRNGYIVSSILTLQKD 480

  Fly   981 -SLPS---TSISRSY----------DSDLRESAIVAGLTPATTFLIRMQA----INEIERSAYTE 1027
             .||.   .|.:..|          |:|....|.:..:.....|:|.:..    |...|:...||
Frog   481 RDLPKPILCSATNLYGKKVHELPFQDTDTLVWAKIGPVGAVVVFVILVAVGGYFIKTREKKNMTE 545

  Fly  1028 AIVLKTQEEAPTEAPSNVQVQTG---------GESELIVTWQIPPRESWNGELIGYTVNCSEEKQ 1083
            :......|.:||....|.:...|         .|..|:...|.|.|...:...|.:|      |:
Frog   546 SSSFIQTEASPTSCSGNGKKNLGKIENQFLSISEKILLSKRQQPSRVDTDYANIDFT------KR 604

  Fly  1084 NI 1085
            |:
Frog   605 NV 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165
		IGc2	553..619	CDD:197706
		I-set	634..724	CDD:254352	24/97 (25%)
		ig	645..712	CDD:278476	18/74 (24%)
		IG_like	734..815	CDD:214653	20/80 (25%)
		Ig	745..815	CDD:299845	19/69 (28%)
		I-set	820..913	CDD:254352	21/103 (20%)
		Ig	838..920	CDD:299845	22/92 (24%)
		FN3	917..1033	CDD:238020	26/152 (17%)
		FN3	1040..1142	CDD:238020	11/55 (20%)
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
mag	XP_004916459.1	Ig	23..131	CDD:416386
		FR1	23..47	CDD:409353
		Ig strand A	23..27	CDD:409353
		Ig strand A'	30..34	CDD:409353
		Ig strand B	36..47	CDD:409353
		CDR1	48..55	CDD:409353
		FR2	56..63	CDD:409353
		Ig strand C	56..63	CDD:409353
		CDR2	64..87	CDD:409353
		Ig strand C'	74..77	CDD:409353
		FR3	88..121	CDD:409353
		Ig strand D	89..93	CDD:409353
		Ig strand E	99..107	CDD:409353
		Ig strand F	114..122	CDD:409353
		CDR3	122..126	CDD:409353
		Ig	142..236	CDD:416386	23/95 (24%)
		Ig strand A	142..146	CDD:409353	2/3 (67%)
		Ig strand B	155..161	CDD:409353	2/5 (40%)
		Ig strand C	172..177	CDD:409353	1/4 (25%)
		Ig strand E	201..207	CDD:409353	1/5 (20%)
		Ig strand F	214..221	CDD:409353	1/6 (17%)
		Ig strand G	228..236	CDD:409353	1/7 (14%)
		Ig_3	241..310	CDD:404760	18/77 (23%)
		Ig strand B	258..262	CDD:409353	0/3 (0%)
		Ig strand C	271..275	CDD:409353	0/3 (0%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	303..308	CDD:409353	2/4 (50%)
		IG	335..410	CDD:214652	21/96 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910