DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and Kirrel2

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_038957463.1 Gene:Kirrel2 / 100359836 RGDID:1308456 Length:711 Species:Rattus norvegicus


Alignment Length:742 Identity:152/742 - (20%)
Similarity:258/742 - (34%) Gaps:178/742 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   373 DW----LHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELK 433
            ||    ||.|.|               |||.:..|:  :|.....:.|                 
  Rat     7 DWTPWVLHKGIP---------------FLSSAIPLL--LGSSPHFLQQ----------------- 37

  Fly   434 LGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDM-- 496
                 ||.:...:.|..|      |.| |.|:......|..|.           .|:|...|:  
  Rat    38 -----PEDMVVLLGQEAR------LPC-ALGAYRGLVQWTKDG-----------LALGGERDLPG 79

  Fly   497 ------SGDVISHLNISHVRP---DDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAI--GP-IK 549
                  ||:..|..:..|::|   :|...|:|.||.: |.....|:|:|..||....:  || :.
  Rat    80 WSRYWISGNSASGQHDLHIKPVELEDEASYECQASQA-GLRSRPAQLHVMVPPEAPQVLGGPSVS 143

  Fly   550 AVAGEDIIVHCPFAG--YPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKN----VEPGRDQG 608
            .|||....:.|...|  .|..::.|.:....|..::.::: ::.|.....::|    ....:|.|
  Rat   144 LVAGVPGNLTCRSRGDARPAPELLWFRDGIRLDGTSFHQI-TLRDKATGTVENTLFLTPSSQDDG 207

  Fly   609 -IYTCIVRSRAGEEAR-RDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKD 671
             ...|..||:|....| ..:.|::..||::.....|:..|||.:....|..::......:.|.|.
  Rat   208 ATLICRARSQALPTGRDTAVTLSLQYPPMVTLSAEPQTAQEGEKVTFLCQATAQPPVTGYRWAKG 272

  Fly   672 DSSIPSS----LQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRY 732
            .|.:..:    |::...     :..:.:.:|        |..|||....|.:..|:|...|..:.
  Rat   273 GSPVLGARGPRLEVVAD-----ATFLTEPVS--------CEVSNAVGSANRSTALEVLYGPILQA 324

  Fly   733 EPMDTAIMLGNTISINCEAEGYPIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMC 797
            :|...::.:|...|.:|...|.|:|.|:|.:..|.......| ::|..|:.|     .|.|.|:|
  Rat   325 KPKPVSVDVGKDASFSCVWRGNPLPRISWTRLGGSQVLSSGP-TLRLPSVAL-----EDAGDYVC 383

  Fly   798 QA---TNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHA-KGDEPITIGWTQNNGR 858
            :|   ...:|.|..:. |:.||.|. ...:.....:....|..|.|.. ....|.::.|:.:.|.
  Rat   384 RAEPRRTGVGGGTAQA-RLTVNAPP-VVTALHPAPAFLRGPARLQCVVFASPAPDSVVWSWDEGF 446

  Fly   859 IDLNNF-RFSIAEMKTEK-------GVDSQLTIGHSDRHD--SGVYRCIAENPYGRAEQIIFLAV 913
            ::..:. ||.:......:       |:.|.|.|..:...|  :| :.|.|.|..|.....|.|..
  Rat   447 LEAGSLGRFLVEAFPAPEVEGGQGPGLISVLHISGTQESDFTTG-FNCSARNRLGEGRVQIHLGR 510

  Fly   914 QERPDT--------PSHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAG 970
            ::...|        .:...:|.|.:..|...||                        ||||:...
  Rat   511 RDLLPTVRLVAGAASAATSLFMVITGVVLCCWR------------------------HGSLSKQK 551

  Fly   971 GDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQE 1035
            .       .|.:|.:|...|......|:.......|             |..:.:.: :||:..|
  Rat   552 N-------LVRIPGSSEGSSAHGPEEETGSSEDRGP-------------IVHTDHND-LVLEENE 595

  Fly  1036 EAPTEAPSNVQVQTGGESELIVTWQIP 1062
            ...|:.|:|...:..|.|..:...:.|
  Rat   596 ALETKDPTNGYYKVRGVSVSLSLGEAP 622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352 12/63 (19%)
Ig 358..431 CDD:143165 12/61 (20%)
Ig 456..533 CDD:143165 20/87 (23%)
IGc2 553..619 CDD:197706 13/72 (18%)
I-set 634..724 CDD:254352 17/93 (18%)
ig 645..712 CDD:278476 11/70 (16%)
IG_like 734..815 CDD:214653 22/83 (27%)
Ig 745..815 CDD:299845 20/72 (28%)
I-set 820..913 CDD:254352 20/103 (19%)
Ig 838..920 CDD:299845 20/100 (20%)
FN3 917..1033 CDD:238020 19/123 (15%)
FN3 1040..1142 CDD:238020 5/23 (22%)
fn3 1150..1237 CDD:278470
FN3 1263..1345 CDD:238020
Ig 1350..1436 CDD:299845
IG_like 1358..1436 CDD:214653
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
Kirrel2XP_038957463.1 IG_like 38..127 CDD:214653 26/107 (24%)
Ig strand A' 40..44 CDD:409353 0/3 (0%)
Ig strand B 48..57 CDD:409353 4/15 (27%)
Ig strand C 62..66 CDD:409353 1/3 (33%)
Ig strand D 75..85 CDD:409353 1/9 (11%)
Ig strand E 88..100 CDD:409353 2/11 (18%)
Ig strand F 107..115 CDD:409353 3/7 (43%)
Ig strand G 117..127 CDD:409353 3/9 (33%)
Ig 133..231 CDD:416386 20/98 (20%)
Ig strand A 134..137 CDD:409353 0/2 (0%)
Ig strand A' 140..144 CDD:409353 1/3 (33%)
Ig strand B 151..158 CDD:409353 1/6 (17%)
Ig strand C 164..169 CDD:409353 0/4 (0%)
Ig strand C' 172..174 CDD:409353 0/1 (0%)
Ig strand D 177..184 CDD:409353 0/7 (0%)
Ig strand E 191..199 CDD:409353 1/7 (14%)
Ig strand F 208..216 CDD:409353 1/7 (14%)
Ig strand G 222..228 CDD:409353 1/5 (20%)
Ig_3 234..303 CDD:404760 13/81 (16%)
Ig strand B 252..256 CDD:409353 0/3 (0%)
Ig strand C 266..270 CDD:409353 0/3 (0%)
Ig strand E 283..286 CDD:409353 1/2 (50%)
Ig strand F 292..301 CDD:409353 2/16 (13%)
Ig strand G 309..312 CDD:409353 1/2 (50%)
Ig 326..403 CDD:416386 22/83 (27%)
Ig strand A' 327..332 CDD:409353 0/4 (0%)
Ig strand B 335..344 CDD:409353 2/8 (25%)
Ig strand C 350..354 CDD:409353 1/3 (33%)
Ig strand C' 357..359 CDD:409353 0/1 (0%)
Ig strand D 362..365 CDD:409353 0/2 (0%)
Ig strand E 366..371 CDD:409353 2/5 (40%)
Ig strand F 379..387 CDD:409353 4/7 (57%)
Ig strand G 393..403 CDD:409353 3/10 (30%)
Ig 405..509 CDD:416386 20/105 (19%)
Ig strand A 406..410 CDD:409353 1/4 (25%)
Ig strand A' 412..415 CDD:409353 0/2 (0%)
Ig strand B 423..430 CDD:409353 2/6 (33%)
Ig strand C 437..442 CDD:409353 1/4 (25%)
Ig strand C' 444..447 CDD:409353 1/2 (50%)
Ig strand D 455..462 CDD:409353 1/6 (17%)
Ig strand E 472..479 CDD:409353 3/6 (50%)
Ig strand F 490..497 CDD:409353 3/7 (43%)
Ig strand G 500..507 CDD:409353 1/6 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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