DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and nectin1l1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_031752313.1	Gene:	nectin1l1 / 100145297	XenbaseID:	XB-GENE-22065634	Length:	458	Species:	Xenopus tropicalis

Alignment Length:	507	Identity:	108/507 - (21%)
Similarity:	174/507 - (34%)	Gaps:	129/507 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   447 EQNVRPGPLISLKCSASGSPP--PQFAWLLDSQPIMDVSL--------HHRFAIGQFVDM--SGD 499
            |.|.:.|....|.|... :|.  .|..|.....|..:..|        .|....||.|..  :||
Frog    35 EVNAKLGSDAKLNCKVK-TPDIISQVTWQRKLSPNNENFLTYSKGEEPMHLTPFGQRVKFLGNGD 98

  Fly   500 VISHLNISHVRPDDGGLYKCVASNSMGSVQHS-ARLNVYGPPYVRAIGPIKAV----AGEDIIVH 559
            :...:.|.:|...|.|.|.|:.:...|..:.: .:|.:..||.: .:.|.:.|    :...|.|.
Frog    99 LGGSIRIPNVTLADQGTYLCIFTTFPGGTKEAEIKLVIQVPPKI-TLEPTEPVLSGPSPSPIAVC 162

  Fly   560 CPFAGYPVEQIRW---EKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEE 621
            ..:|..|...|.|   |..:.....|.:||..:|:...|||...: ||.:....||:|....|:.
Frog   163 RAWAAKPAVNITWIFSEARYISEENSTNYENGTVSTCSQLVTVPL-PGHNGRNVTCVVSQSDGKS 226

  Fly   622 ARRDMQL----NVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQIT 682
            .....|.    ::...|.::.....|   :.|..|::|..........|.||:|:..:|.:
Frog   227 MESWSQTLTIQHIYYAPEVKAKVIAK---DDGTIQLSCRADCNPPATEFLWKRDEMDLPDN---- 284

  Fly   683 EKKEEFYSLLVFKDISAR-HSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTIS 746
                |...|...:.:||. ..|.|.|.|.|   :|.|::
Frog   285 ----EAEELGATRLLSANTWKGYYACVAGN---EVGYSS-------------------------- 316

  Fly   747 INCEAEGY-PIPTITWFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKKT 810
                  || .:.|:|   ..|..:..:.||.:...|||:|:        |:.            .
Frog   317 ------GYIYVQTVT---VPGTCNVHYIPLILLIPSLLINI--------YVA------------V 352

  Fly   811 IRINVNEPARFEQSARNISSRRN-DPV-----TLDC----HAKG--DEP--ITIGWTQNNGRIDL 861
            |.....:..|:..|...:..|.| .|:     .|.|    ||:.  |:.  .|:...::|..||
Frog   353 IHYRNKKRERYRNSECCLRFRSNCTPILRHIQRLGCCGEDHAEAPTDDAGNATLSVQRDNQHID- 416

  Fly   862 NNFRFSIAEMKTEKGVDSQLTIGHSDRHDSG-VYRC----IAENPYGRAEQI 908
                       ::.|......:|..||..|| :.:|    :|.:|....|.|
Frog   417 -----------SQGGPSPSSELGGHDRGASGAILQCTSMTMARDPDSSVEDI 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652
		Ig	56..125	CDD:143165
		I-set	246..337	CDD:254352
		Ig	264..334	CDD:143165
		I-set	345..433	CDD:254352
		Ig	358..431	CDD:143165
		Ig	456..533	CDD:143165	20/89 (22%)
		IGc2	553..619	CDD:197706	19/68 (28%)
		I-set	634..724	CDD:254352	21/90 (23%)
		ig	645..712	CDD:278476	16/67 (24%)
		IG_like	734..815	CDD:214653	13/81 (16%)
		Ig	745..815	CDD:299845	13/70 (19%)
		I-set	820..913	CDD:254352	25/108 (23%)
		Ig	838..920	CDD:299845	20/84 (24%)
		FN3	917..1033	CDD:238020
		FN3	1040..1142	CDD:238020
		fn3	1150..1237	CDD:278470
		FN3	1263..1345	CDD:238020
		Ig	1350..1436	CDD:299845
		IG_like	1358..1436	CDD:214653
		FN3	1441..1530	CDD:238020
		FN3	1542..1620	CDD:238020
nectin1l1	XP_031752313.1	Ig	29..136	CDD:416386	24/101 (24%)
		FR1	29..51	CDD:409353	5/15 (33%)
		Ig strand A	29..32	CDD:409353
		Ig strand A'	34..38	CDD:409353	1/2 (50%)
		Ig strand B	43..51	CDD:409353	2/7 (29%)
		FR2	57..63	CDD:409353	2/5 (40%)
		Ig strand C	58..63	CDD:409353	2/4 (50%)
		CDR2	64..83	CDD:409353	2/18 (11%)
		Ig strand C'	73..78	CDD:409353	1/4 (25%)
		Ig strand C'	80..84	CDD:409353	0/3 (0%)
		FR3	84..122	CDD:409353	11/37 (30%)
		Ig strand D	91..95	CDD:409353	1/3 (33%)
		Ig strand E	100..107	CDD:409353	1/6 (17%)
		Ig strand F	114..122	CDD:409353	3/7 (43%)
		CDR3	123..126	CDD:409353	0/2 (0%)
		Ig strand G	126..136	CDD:409353	1/9 (11%)
		FR4	127..136	CDD:409353	1/8 (13%)
		Ig	140..237	CDD:416386	24/98 (24%)
		Ig strand A	140..147	CDD:409353	1/7 (14%)
		Ig strand B	158..165	CDD:409353	2/6 (33%)
		Ig strand C	170..176	CDD:409353	1/5 (20%)
		Ig strand D	180..188	CDD:409353	0/7 (0%)
		Ig strand E	196..204	CDD:409353	3/7 (43%)
		Ig strand F	214..221	CDD:409353	3/6 (50%)
		Ig strand G	227..233	CDD:409353	0/5 (0%)
		Ig	254..316	CDD:416386	19/72 (26%)
		Ig strand B	255..264	CDD:409353	3/8 (38%)
		Ig strand C	270..276	CDD:409353	2/5 (40%)
		Ig strand C'	279..282	CDD:409353	0/2 (0%)
		Ig strand D	285..290	CDD:409353	1/4 (25%)
		Ig strand E	291..298	CDD:409353	1/6 (17%)
		Ig strand F	302..310	CDD:409353	4/7 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910