DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and cd22

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_017945135.2 Gene:cd22 / 100135351 XenbaseID:XB-GENE-5887760 Length:858 Species:Xenopus tropicalis


Alignment Length:781 Identity:170/781 - (21%)
Similarity:277/781 - (35%) Gaps:182/781 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   402 LLVQNVGRRDRGVY--QCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRP------------ 452
            :::.||...|.|.|  :.:..|.:...:....|.:.|:.|||:       :||            
 Frog   114 IVLHNVQEGDSGYYRLRTIDGNDQWMTKKNVSLTVSDSGPELM-------IRPVGVGREYQKLTL 171

  Fly   453 -------GPLISLKCSASG-------SPPPQFAW-LLDSQPIMDVSLHHRFAIGQFVDMSGDVIS 502
                   .|...:|.|..|       :..|:..| :.:.:|||                   ..:
 Frog   172 SCYVHYYCPDYDIKLSWDGDVRGETKTTVPRLEWSVRNKKPIM-------------------TEA 217

  Fly   503 HLNISHVRPDDGGLYKCVASNSMGSVQHSAR--LNV-YGPPYVR---AIGPIKAVAGEDIIVHC- 560
            ....:....|.....:|..:.....|..:..  ||: |.|..||   ...|:....||::.:.| 
 Frog   218 EFTFTPTWEDHNKTIQCALTKGDSEVTKTGPVVLNIQYSPKGVRIRPETSPVTISKGEEVALECT 282

  Fly   561 -PFAGYPVEQIRWEKAHQELTTSN-HYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEAR 623
             ..:..|::..||.|:...:..|| ||.                 .|:.|.|.|...:..|....
 Frog   283 AESSNPPIDTYRWYKSANNIVGSNSHYS-----------------ARESGTYYCEAENTIGRTRS 330

  Fly   624 RDMQLNVNSPPVIEPFKFP-KNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEE 687
            :.:.:||...|.: ..|.| :.::||.:..:||:|.:....:..:|.||...|.:..:.|     
 Frog   331 KGVAINVLYAPTV-TLKIPSREIREGSQYTLTCSVDANPQLVNITWYKDYEKILNKNRDT----- 389

  Fly   688 FYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVA-----PRWRYEPMDTAIMLGNTISI 747
                |.|..|..:.||.|.|.|.|.....: :|::.|.|.     |....||...:.:.|:::..
 Frog   390 ----LTFPYIREQESGSYHCEAQNIIGSES-SADVYVDVVYAPKNPEVVVEPKKPSFVEGSSLRF 449

  Fly   748 NC--EAEGYPIPTITWFKGQGKGSKDFKPL-SMRNHSLLLNLATDNDEGYYMCQATNEIGAGLKK 809
            :|  .:....:..|||:|.:       |.: |.|.:.::::...:...|.|||:|.|:|||...:
 Frog   450 SCNVNSSNPGVSQITWYKNE-------KVMASERKNYIIIDTIKEEHHGNYMCKAGNKIGATSSQ 507

  Fly   810 TIRINVNEP---ARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEM 871
            .:.|||..|   .|....|:.|:  ..|.:.|.|......|            .:..||: ..:.
 Frog   508 AVSINVLYPPKGVRVTPQAQIIT--EGDRIRLACSVDKSNP------------TVTEFRW-YKDS 557

  Fly   872 KTEKGVDSQLTIGHSDRHDSGVYRCIAENPYGR-AEQIIFLAVQERP------DTPSHLEIFEVG 929
            ..:...:.::|.....|.|||.|.|.|.|..|. ..|.|.|.||..|      ..||:|    |.
 Frog   558 ALQPHRNKEITFPGIKRTDSGKYTCEARNGIGNVTSQPITLNVQYAPVGVMVSSIPSNL----VT 618

  Fly   930 SRTVKLSWRRPFDGNSPVLSYLVQYQA--LKYLQS----HGSLAAAG----------GDWNGHV- 977
            ..| |::...........:||.:....  |||.||    :..|:..|          |...... 
 Frog   619 EHT-KVTLTCTAQAYPNTISYAIYKDGVLLKYSQSLVLDYIQLSDGGEYYCMATNSIGSGTSRTI 682

  Fly   978 -INVSLPSTSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVL-KTQEEAPTE 1040
             |:||...|||.:.....:....::..|..|..|.|...........:.:..||: ||..|.|..
 Frog   683 DIHVSYGLTSIGKYIGIAVGIFTLLVLLIVAIHFKIWKMVFRFKADDSESHFIVMKKTHPELPDN 747

  Fly  1041 APSNVQVQTGGESELIVTWQIPPRESWNGELIGYTV--------NCSEEKQNINFISVVNSSLKS 1097
            |..                |.||..|...:| .|::        ..:..:.|.|...|:.|.|:.
 Frog   748 AAR----------------QSPPVGSHLDQL-NYSIIQFPPQPEGGAASRTNPNDQGVIYSVLQK 795

  Fly  1098 T 1098
            |
 Frog   796 T 796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352
Ig 264..334 CDD:143165
I-set 345..433 CDD:254352 6/32 (19%)
Ig 358..431 CDD:143165 6/30 (20%)
Ig 456..533 CDD:143165 11/84 (13%)
IGc2 553..619 CDD:197706 15/68 (22%)
I-set 634..724 CDD:254352 23/90 (26%)
ig 645..712 CDD:278476 18/66 (27%)
IG_like 734..815 CDD:214653 20/83 (24%)
Ig 745..815 CDD:299845 18/72 (25%)
I-set 820..913 CDD:254352 22/93 (24%)
Ig 838..920 CDD:299845 21/88 (24%)
FN3 917..1033 CDD:238020 29/140 (21%)
FN3 1040..1142 CDD:238020 13/67 (19%)
fn3 1150..1237 CDD:278470
FN3 1263..1345 CDD:238020
Ig 1350..1436 CDD:299845
IG_like 1358..1436 CDD:214653
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
cd22XP_017945135.2 Ig 35..149 CDD:416386 7/34 (21%)
FR1 35..55 CDD:409353
Ig strand A' 40..44 CDD:409353
Ig strand B 46..56 CDD:409353
CDR1 56..62 CDD:409353
Ig strand C 62..69 CDD:409353
FR2 63..69 CDD:409353
CDR2 70..99 CDD:409353
Ig strand C1 71..74 CDD:409353
Ig strand C2 77..81 CDD:409353
Ig strand C' 85..88 CDD:409353
FR3 100..133 CDD:409353 5/18 (28%)
Ig strand D 101..105 CDD:409353
Ig strand E 110..118 CDD:409353 0/3 (0%)
Ig strand F 125..133 CDD:409353 2/7 (29%)
CDR3 134..136 CDD:409353 0/1 (0%)
FR4 137..149 CDD:409353 1/11 (9%)
Ig strand G 137..149 CDD:409353 1/11 (9%)
Ig 164..253 CDD:416386 13/107 (12%)
Ig strand B 168..176 CDD:409353 0/7 (0%)
Ig strand C 184..190 CDD:409353 2/5 (40%)
Ig strand C' 192..195 CDD:409353 0/2 (0%)
Ig strand D 200..206 CDD:409353 1/5 (20%)
Ig strand E 213..222 CDD:409353 2/27 (7%)
Ig strand F 230..238 CDD:409353 1/7 (14%)
Ig strand G 243..251 CDD:409353 1/7 (14%)
Ig 257..339 CDD:416386 22/98 (22%)
Ig strand A 257..265 CDD:409353 3/7 (43%)
Ig strand A' 269..273 CDD:409353 0/3 (0%)
Ig strand B 274..284 CDD:409353 3/9 (33%)
Ig strand C 291..297 CDD:409353 2/5 (40%)
Ig strand C' 299..302 CDD:409353 0/2 (0%)
Ig strand F 315..323 CDD:409353 3/7 (43%)
Ig strand G 326..339 CDD:409353 3/12 (25%)
Ig 341..425 CDD:416386 25/94 (27%)
Ig strand A 341..347 CDD:409353 1/6 (17%)
Ig strand A' 351..354 CDD:409353 0/2 (0%)
Ig strand B 355..365 CDD:409353 3/9 (33%)
Ig strand C 371..377 CDD:409353 1/5 (20%)
Ig strand C' 379..382 CDD:409353 0/2 (0%)
Ig strand E 388..394 CDD:409353 3/14 (21%)
Ig strand F 401..409 CDD:409353 4/7 (57%)
Ig strand G 412..425 CDD:409353 3/13 (23%)
Ig_3 430..499 CDD:404760 17/75 (23%)
Ig strand A 430..433 CDD:409353 1/2 (50%)
Ig strand A' 438..442 CDD:409353 0/3 (0%)
Ig strand B 445..454 CDD:409353 1/8 (13%)
Ig strand E 478..484 CDD:409353 0/5 (0%)
Ig strand F 491..499 CDD:409353 5/7 (71%)
Ig strand G 504..513 CDD:409353 1/8 (13%)
Ig 516..602 CDD:416386 24/100 (24%)
Ig strand A 516..523 CDD:409353 2/6 (33%)
Ig strand A' 527..531 CDD:409353 1/5 (20%)
Ig strand B 532..542 CDD:409353 3/9 (33%)
Ig strand C 549..555 CDD:409353 2/6 (33%)
Ig strand E 565..571 CDD:409353 1/5 (20%)
Ig strand F 578..586 CDD:409353 4/7 (57%)
Ig strand G 589..602 CDD:409353 5/12 (42%)
Ig_2 617..683 CDD:404734 13/66 (20%)
Ig strand B 623..627 CDD:409353 0/3 (0%)
Ig strand C 635..641 CDD:409353 2/5 (40%)
Ig strand E 651..655 CDD:409353 2/3 (67%)
Ig strand F 665..670 CDD:409353 0/4 (0%)
Ig strand G 679..682 CDD:409353 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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