DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam3 and ncam1

DIOPT Version :9

Sequence 1:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster
Sequence 2:XP_017951446.2 Gene:ncam1 / 100038291 XenbaseID:XB-GENE-923171 Length:1119 Species:Xenopus tropicalis


Alignment Length:1294 Identity:274/1294 - (21%)
Similarity:431/1294 - (33%) Gaps:401/1294 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   219 VTNTLNGERQRSDA---VMLQVKELSKNL-------APRTTQKPVMEIHVERGNDVHLPCNIQGN 273
            |||  ...|:.|.|   .|||:|:|...|       |...|..| .:..:..|......|.:.|.
 Frog     8 VTN--RSSRRNSIACRITMLQIKDLIWTLYFIGTAVALEVTIVP-DQGEISLGESKFFLCQVSGE 69

  Fly   274 PFPIFTWYRVSDSAALYPIPSSQRVILSRTLLLIK-----------NADERDAGKWICQASNQF- 326
            ...| :||.          |:.::::..:.:.::|           |...:|||.:.|.||::. 
 Frog    70 ASDI-SWYS----------PAGEKLLNQQQISVVKNDGYTSTLTIYNVSSQDAGIYKCVASSETE 123

  Fly   327 GEQRIEIRLSVNSYVSVHILPQVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGR 391
            ||....:.|.:...::....|..|....|..|...|..:.|....|.|.|.||.:..       :
 Frog   124 GESEGTVNLKIYQKLTFKNAPTPQEFIEGEDAVIICDVSSSIPSIITWRHRGKDVIL-------K 181

  Fly   392 DNIRF--LSKSSLLVQNVGRRDRGVYQCLVENQRASAQAMAELKLGD-----TVPELIYT---FI 446
            .::||  ||.:.|.::.|.:.|.|.|:|     .....|..|:...|     .||..:..   .:
 Frog   182 KDVRFVVLSNNYLQIRGVKKTDEGTYRC-----EGRILARGEINYKDIHVIVNVPPTVQARQIRV 241

  Fly   447 EQNVRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRP 511
            .........:.|.|.|.|.|.|:.:||...:||.|         |:......:..|.:.|..|..
 Frog   242 NATANMDESVVLSCDADGFPDPEISWLKKGEPIED---------GEEKISFNEDKSEMTIYRVGK 297

  Fly   512 DDGGLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAH 576
            ||...|.|:|:|..|..:....|.||..|.:..:....||..::|.:.|..:|.|:..|.|..|.
 Frog   298 DDEAEYSCIANNKAGEAEAIILLKVYAKPKITYVENKTAVELDEITLTCEASGDPIPSISWRTAT 362

  Fly   577 QELTTSNHYELASVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKF 641
            :.:::..     ...| |.:|:|                    |..|                  
 Frog   363 RNISSEE-----KTLD-GHIVVK--------------------EHIR------------------ 383

  Fly   642 PKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFKDISARHSGKYT 706
                                                           .|.|..|||....:|:|.
 Frog   384 -----------------------------------------------MSALTLKDIQYTDAGEYI 401

  Fly   707 CYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTITWFK-GQGKGSK 770
            |.||||..:.......:|:.||:.: .|:......||.::|.||...||...::||: ||...|.
 Frog   402 CIASNAIGEDMRAMYFEVQYAPKIK-GPVVVYTWEGNPVNITCEVLAYPSAVVSWFRDGQLLPSS 465

  Fly   771 DFKPLSM----RNHSLLLNLATDNDEGYYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSR 831
            :|..:.:    .:.||.:|..::||.|.|.|.|.|.||....:.|.:..:.|:       :.:..
 Frog   466 NFSNIKIYSGPSSSSLEVNPDSENDFGNYNCTAVNSIGHESSEFILVQADTPS-------SPAIL 523

  Fly   832 RNDPVTLDCHAKGDEPITIGWTQNNGRIDLNNFRFSIAEMKT--------------EKGVDSQLT 882
            |.:|.:.......|||      ...|.:.:..::   ||.|.              |...:|.:|
 Frog   524 RVEPYSSTVMVIFDEP------DATGGVPILKYK---AEWKVIGQEKWHAKYYDAKEVSAESIIT 579

  Fly   883 IGHSDRHDSGVYRCIAENPYGRAE---------QIIFLA-VQERPDTPS---HLEIFEVGSRTVK 934
            :.......|.:.:..|.|..|..:         |.:.:| .|..|..|.   ||.  |.|: .||
 Frog   580 VTGLKPETSYLVKLSAVNGKGLGDSTPSQEFTTQPVNIAKPQGEPSAPKLVWHLN--EDGN-NVK 641

  Fly   935 LSWRRPFDGNSPVLSYLVQYQALKYL----------QSHGSLAAAGGDWN--GHVINV------- 980
            :...:..||.||:..|||.|:||...          .||..:..| .:||  ..||.|       
 Frog   642 VEIIKQDDGGSPIRHYLVNYRALNAADWKPEMRVPSSSHHVMLKA-LEWNVEYEVIVVAENQQGK 705

  Fly   981 SLP------------STSISRSYDSDLRESAIVAGL----------TPATTF------LIRMQAI 1017
            |.|            :|:.:.|..:.|...|||..|          ...|.|      |:...|:
 Frog   706 SKPARLSFRTTAKPTATTATTSASAGLGTGAIVGILIVIFVLLLVVVDVTCFFLNKCGLLMCIAV 770

  Fly  1018 N------------EIE--RSAYT-----EAIV-LKTQEE-----------APTEAPSNVQVQTGG 1051
            |            :||  ::|::     |.|| ::|:||           .|.|.....:.:...
 Frog   771 NFCGKAGPGAKGKDIEEGKAAFSKDESKEPIVEVRTEEERTPNHDGSNQIEPNETTPLTEPEHPA 835

  Fly  1052 ESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNS--SLKSTIVSGWA----TTKATL 1110
            ::...|...:|...         ||..:.:.....|.:..||  |..:|:.|..|    |...|:
 Frog   836 DTTATVEDMLPSVT---------TVTTNSDTITETFATAQNSPTSESTTLTSSTAPPPTTDSNTV 891

  Fly  1111 RGLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAP--------------QNVNCTALSS 1161
            :.::     |...:|..|..|.|        .....|:.||              ...|.....:
 Frog   892 QSIQ-----ATPSKAEASTASSP--------PPTSSPKVAPLVDLSDTPTNNPSKAGANQAGALN 943

  Fly  1162 QSLKISWLEPPLQFHGGIIQGYKILYRPI----VHQIDFPAKLEIKRTSNLETYLHTLHKASNYS 1222
            .|...|..|||           |.:.:|:    .:....|...|.|:....::...:..|.:...
 Frog   944 PSAATSAAEPP-----------KAIIKPVATVPANATSPPPTPEPKQVKQEQSGSKSPEKEAAQP 997

  Fly  1223 IRVLAYT-ATGDGLAS----HPL-----------------------FCQTDDDVPDAPAAIKAAA 1259
            ..|.:.| ||.|..||    .||                       |.......|.|.|:.||:.
 Frog   998 STVKSPTEATKDESASLSNTKPLQGEDFQIDGGTFKTPEIDLAKDVFAALGTATPAAVASGKASE 1062

  Fly  1260 L---TADSILISWLTPKNRNGIISHYTVYSREAGRKGQAKTHMVRVDENGYPVTFESRS 1315
            |   |||:.:     |.:                   .|||...:|:||..|...:.:|
 Frog  1063 LVSSTADTSV-----PPD-------------------SAKTEKTQVEENSKPEETDVKS 1097

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam3NP_996226.2 IG 56..133 CDD:214652
Ig 56..125 CDD:143165
I-set 246..337 CDD:254352 20/102 (20%)
Ig 264..334 CDD:143165 16/81 (20%)
I-set 345..433 CDD:254352 23/89 (26%)
Ig 358..431 CDD:143165 19/74 (26%)
Ig 456..533 CDD:143165 22/76 (29%)
IGc2 553..619 CDD:197706 11/65 (17%)
I-set 634..724 CDD:254352 12/89 (13%)
ig 645..712 CDD:278476 10/66 (15%)
IG_like 734..815 CDD:214653 27/85 (32%)
Ig 745..815 CDD:299845 24/74 (32%)
I-set 820..913 CDD:254352 18/116 (16%)
Ig 838..920 CDD:299845 18/105 (17%)
FN3 917..1033 CDD:238020 46/185 (25%)
FN3 1040..1142 CDD:238020 19/107 (18%)
fn3 1150..1237 CDD:278470 19/105 (18%)
FN3 1263..1345 CDD:238020 10/53 (19%)
Ig 1350..1436 CDD:299845
IG_like 1358..1436 CDD:214653
FN3 1441..1530 CDD:238020
FN3 1542..1620 CDD:238020
ncam1XP_017951446.2 Ig 43..136 CDD:416386 20/104 (19%)
Ig strand A 43..48 CDD:409353 1/4 (25%)
Ig strand A' 51..55 CDD:409353 0/3 (0%)
Ig strand B 57..67 CDD:409353 2/9 (22%)
Ig strand C 71..77 CDD:409353 2/6 (33%)
Ig strand C' 80..82 CDD:409353 0/1 (0%)
Ig strand D 89..95 CDD:409353 1/5 (20%)
Ig strand E 97..105 CDD:409353 0/7 (0%)
Ig strand F 112..120 CDD:409353 3/7 (43%)
Ig strand G 124..135 CDD:409353 3/10 (30%)
IG 144..210 CDD:214652 21/77 (27%)
IgI_3_NCAM-1 231..325 CDD:143207 26/102 (25%)
Ig strand B 251..255 CDD:143207 1/3 (33%)
Ig strand C 264..268 CDD:143207 0/3 (0%)
Ig strand E 288..292 CDD:143207 1/3 (33%)
Ig strand F 302..307 CDD:143207 2/4 (50%)
Ig strand G 315..318 CDD:143207 0/2 (0%)
Ig 324..419 CDD:416386 28/185 (15%)
Ig strand A 324..329 CDD:409353 1/4 (25%)
Ig strand A' 333..337 CDD:409353 0/3 (0%)
Ig strand B 341..349 CDD:409353 2/7 (29%)
Ig strand C 355..361 CDD:409353 2/5 (40%)
Ig strand C' 364..367 CDD:409353 0/2 (0%)
Ig strand D 375..381 CDD:409353 2/25 (8%)
Ig strand E 384..390 CDD:409353 2/5 (40%)
Ig strand F 398..406 CDD:409353 4/7 (57%)
Ig strand G 409..419 CDD:409353 0/9 (0%)
Ig_3 423..500 CDD:404760 24/77 (31%)
Ig strand B 439..443 CDD:409353 1/3 (33%)
Ig strand C 452..456 CDD:409353 0/3 (0%)
Ig strand E 479..483 CDD:409353 2/3 (67%)
Ig strand F 493..498 CDD:409353 2/4 (50%)
FN3 517..612 CDD:238020 17/110 (15%)
FN3 624..709 CDD:238020 27/88 (31%)
Herpes_BLLF1 <776..>1116 CDD:282904 72/379 (19%)
PRK07994 <918..1075 CDD:236138 34/172 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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