DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dscam3 and dscaml1

DIOPT Version :9

Sequence 1:	NP_996226.2	Gene:	Dscam3 / 42103	FlyBaseID:	FBgn0261046	Length:	2087	Species:	Drosophila melanogaster
Sequence 2:	XP_005157551.1	Gene:	dscaml1 / 100002762	-ID:	-	Length:	2158	Species:	Danio rerio

Alignment Length:	2256	Identity:	639/2256 - (28%)
Similarity:	974/2256 - (43%)	Gaps:	390/2256 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLLEPPCLVLEKALLLGALLLA---VLATP----------------LLATSGLRVPTFLL----- 42
            |:||.|.|.||::  .|:::..   .||.|                :.|..|:.:.|.||
Zfish    20 SVLESPGLGLERS--PGSIVTTPARSLAWPNTARCTRRDCKTFLRNIPAIYGMWLVTLLLLYSFQ 82

  Fly    43 ----------------EPAPRLLFGNDTGAQVTCTAHGSPPPLVTWVLRDGSLATQVPGLRKISG 91
                            ....|:.|.:..|..:.|.|.|:|..::.|.|..|.....||.:|.:..
Zfish    83 EVHSEDVVSTRLYFVNASLQRVTFSSSVGVSLPCPAGGAPHAVLRWYLATGDDIYDVPHIRHVHA 147

  Fly    92 NGTLHFPPFLAQYYRTDVHEATYRCRASNEAGTVLSRNVQVHAVVRRQFHVHVENTEVYLGNSAL 156
            ||||...||....:.:.:|:..|.|.|.|:||.:.|.:::|.||.|..:.|.|.:.....||.|:
Zfish   148 NGTLQLYPFSPSAFNSFIHDNDYFCTAENQAGKIRSPSIRVKAVFREPYTVRVADQRSMRGNVAV 212

  Fly   157 IKCAIPEYVRPYVRVASWHRGEEILLPDLSDVAGRYVVLAASGDLYVRSVRSEDGLMKFSCLVTN 221
            .||.||..|:.||.|.||.:....::|      |....|.:.|.||:..|:.||.|..:.|:..:
Zfish   213 FKCLIPSAVQEYVSVVSWEKDTVSIVP------GNRFFLTSYGALYISDVQKEDALSTYRCITKH 271

  Fly   222 TLNGERQRSDAVMLQVKELSKNLAPRTTQKPVMEI----HVERGNDVHLPCNIQGNPFPIFTWYR 282
            ..:||.::|:...|.|      |.|..:...||:.    .|:.|..:.|||...|.|.|...|
Zfish   272 KYSGETRQSNGARLSV------LDPTESTPSVMDSFQSGEVQVGRSIELPCIASGYPNPTIRW-- 328

  Fly   283 VSDSAALYPIPSSQRVILSRTLLLIKNADERDAGKWICQASNQFGEQRIEIRLSVNSYVSVHILP 347
            :.|..   |:|:..|.....|.|.|.:....|:|.:||:.:|.||.:.:...|:|...:.|.:.|
Zfish   329 LKDGR---PLPADSRWTRRLTGLTISDLRLEDSGNYICEVTNSFGSKEVTGHLNVIEPLRVTLSP 390

  Fly   348 QVQIVNSGGTANFNCTTTGSAIDAIDWLHNGKPLQANNALTTGRDNIRFLSKSSLLVQNVGRRDR 412
            :........|...:|...||....:.|..|.:|:..:...     :|:.....:|.:....:|..
Zfish   391 KNLKTGISSTVILSCAVQGSPHFTVSWFRNTEPIVPDQHF-----SIQGAHNETLFITAAQKRHS 450

  Fly   413 GVYQCLVENQRASAQAMAELKLGDTVPELIYTFIEQNVRPGPLISLKCSASGSPPPQFAWLLDSQ 477
            |.|||....:..:||..:.:.|.|..|.::.:|.|:.|.||...||.|:|.|:|||...|.||.:
Zfish   451 GAYQCFATRKGQTAQDFSIILLEDGTPRIVSSFSERVVAPGEPFSLMCAAKGAPPPTITWTLDDE 515

  Fly   478 PIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDGGLYKCVASNSMGSVQHSARLNVYGPPYV 542
            |:...|.|.   ..|:....|..:||:|:::.:..|||:|:|.|.||.||.::.||:||.|||.:
Zfish   516 PVARDSAHR---ASQYTLSDGSTVSHVNVTNPQIRDGGVYRCAARNSAGSAEYQARINVRGPPSI 577

  Fly   543 RAIGPIKAVAGEDIIVHCPFAGYPVEQIRWEKAHQELTTSNHYELASVADGGQLVIKNVEPGRDQ 607
            ||:..|.||||.:..::|...|||...|:|.|... |...||.::  |.:.|.|.:.:|:.|.|:
Zfish   578 RAMRNITAVAGRNTFINCRVIGYPYYSIKWYKDGM-LLPDNHRQV--VYENGTLKLSDVQKGMDE 639

  Fly   608 GIYTCIVRSRAGEEARRDMQLNVNSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDD 672
            |.|.|.|..:......:.:.:.|..||:|:||.||.. ..|....|.|.||||||||..:|:||.
Zfish   640 GAYLCSVLIQPQLSISQTVYVTVKVPPLIQPFDFPPT-SIGKLMYIACVVSSGDMPIRITWRKDG 703

  Fly   673 SSIPS-SLQITEKKEEFYSLLVFKDISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMD 736
            ..|.| :..:|.:.:||.|.|....:|.:|:|.|||.|||.||.|:...:|.|.|.||:|.:|.:
Zfish   704 QEIVSGTAGVTIETKEFMSSLQISKVSLKHNGNYTCIASNDAATVSSERQLIVTVPPRFRVQPNN 768

  Fly   737 TAIMLGNTISINCEAEGYPIPTITWFKGQGKGS-KDFKPLS-------MRNHSLLLNLATDNDEG 793
            ...:.|.:..:||..||||.|.:.|...:|.|: :.:.|:.       :.|.|||:....:.|.|
Zfish   769 QDGIYGKSEVLNCSVEGYPPPKVVWKHAKGIGNPQQYHPVPLTGRIQILSNGSLLIRHVLEEDRG 833

  Fly   794 YYMCQATNEIGAGLKKTIRINVNEPARFEQSARNISSRRNDPVTLDCHAKGDEPITIGWTQNNGR 858
            ||:|||:|.:|:.:.|::.:.|..||..........:.:.....|:|.|:|:.||.|.|.:.:..
Zfish   834 YYLCQASNGVGSDISKSMMLTVKIPAMITSHPNTTMAIKGQNKELNCTARGEYPIIIRWERGDTV 898

  Fly   859 IDLN-NFRFSIAEMKTEKG--VDSQLTIGHSDRHDSGVYRCIAENPYGRAEQIIFLAVQERPDTP 920
            ||.: |.|:||.....||.  |.|.|.:..::|.||..:.|.|.|.||....:|.|.|||.|| |
Zfish   899 IDPDRNPRYSITTSPNEKSDEVISTLKLKPAERGDSVFFSCHAINSYGEGRGLIQLTVQEPPD-P 962

  Fly   921 SHLEIFEVGSRTVKLSWRRPFDGNSPVLSYLVQYQALKYLQSHGSLAAAGGDWN-GHVINVSLPS 984
            ..||:.||..|::.|.|.:.|||||.:.||.::|:            .....|. .|......|:
Zfish   963 PELEVREVKDRSMNLRWTQRFDGNSIITSYDIEYK------------NKSDPWELKHATRKISPT 1015

  Fly   985 TSISRSYDSDLRESAIVAGLTPATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTEAPSNVQVQT 1049
            .:           .|.:..|.||:.:.|||.:.|:|.||..::.:.:.|:|..|...|..|.:|.
Zfish  1016 NN-----------QANIVELHPASVYSIRMYSYNKIGRSQASKELTISTEEAPPDGPPMEVILQP 1069

  Fly  1050 GGESELIVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKA---TLR 1111
            .....:.|||:.|.:|..||.:.||.:...|...        .|:.:.:||...||..:   ||.
Zfish  1070 MTSQSIRVTWKAPKKELQNGVIRGYQIGYRENGP--------GSNGQYSIVEMKATGDSEVYTLD 1126

  Fly  1112 GLRKYSRYAVTIRAMNSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFH 1176
            .|:|:::|.|.::|.|..|:||.|:.|..||.|.||...||||....::|....|:|.|||....
Zfish  1127 NLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPQNVRAITVTSDEAVITWSEPPRMTL 1191

  Fly  1177 GGIIQGYKILYRPIVHQIDFP-----------------AKLEIKRTSNLETYLHTLHKASNYSIR 1224
            .|:::||::::..:     :|                 .:::...|:..:..|..|.|.:|||::
Zfish  1192 NGVLKGYRVVFWSL-----YPDGGGCCGGQTLGLNQKWGEMQNITTTREQVELKGLEKFTNYSVQ 1251

  Fly  1225 VLAYTATGDGLASHPLFCQTDDDVPDAPAAIKAAALTADSILISWLTPKNRNGIISHYTVYSREA 1289
            |||||..|||:.|:.|:.||.:|.|..||.|||...:|.|:::|||.|...||||..||:|....
Zfish  1252 VLAYTQAGDGVRSNVLYIQTREDHPGPPAGIKAVPSSASSVVVSWLPPVKPNGIIRKYTIYCSSP 1316

  Fly  1290 GRKGQAKTHMVRVDENGYPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIA 1354
            |....|.:   ..:.|...:.:....|...|.|..|.:|.|:.|.|..:..:......:|||:|.
Zfish  1317 GSGQPAPS---EYEANPELLIYRITHLTRGQQYLIWAAAVTTAGRGNISEKVTVEPAGKAPAKIL 1378

  Fly  1355 SFGQVVRKAVGTGLVLECLAVGNPTPRARWLTRDR-----PVTFSPFYEVTNEGNLKIHRVEGSL 1414
            |||..|.......:.|.|.:||.|||..:| |:|.     |||......:.:.|.|.:..|:...
Zfish  1379 SFGGTVTTPWMKEVRLPCSSVGEPTPTIKW-TKDSEDTAIPVTQDGHRNILSNGTLVLRSVKAED 1442

  Fly  1415 SGNYTCTANNLFGSDEIQYQVIAMKPPSAPQIIVQYASADSIRVSWDAPDDGGAPLQGYTISYHT 1479
            ||.|||||.|..|.|.|...::...||..|::.|...|..||.::|...|:||:.::|:.:.|..
Zfish  1443 SGYYTCTATNTLGFDTIIVNLLVQVPPDQPRLTVSTTSTSSITLAWIPGDNGGSSIRGFVLQYSV 1507

  Fly  1480 AG-ESWSITELLPENNAFTISGLKCGNQYIIKMSAHNMVGSGVASEEINVWTKGKASQAPNANEL 1543
            .. |.|....:.....:|.:..|:||..|.:|::|.|.||:|..||.|...|.|:..|. |.::.
Zfish  1508 DNTEEWKDVFISSSERSFKLDNLRCGTWYKVKLAAKNSVGAGRISEIIEAKTHGREPQF-NKDQP 1571

  Fly  1544 IAT--NATCVNLKLSSWQNGGCSIHHFSIEHRPLGDIRWTVVTSDISNAEENRENLIFCDFLPAK 1606
            :.|  |:|...:.|..|.:|||.|....:|.||.|...|..|.::.|      .::...:...|.
Zfish  1572 LFTHINSTHARMNLQGWTSGGCPITAVLLEFRPKGTWAWQSVRTNAS------ADIFLAELREAT 1630

  Fly  1607 WYQLRISATNDAGKTTEHYHFSTTNIDGITIPPPSVFPSENDLMNNLINSTNPTSGDWFATLIVV 1671
            ||:|::.|.|.||...:...|:|.:.||.||||......|.|.:..|.:...|           |
Zfish  1631 WYELKMKACNSAGCGNQSSQFATLDYDGSTIPPIKSARGEGDDVKKLFSIGCP-----------V 1684

  Fly  1672 VIITV------------------------SIITIALTIKHRRTLCGPIAE--------------- 1697
            :::|:                        |:..:.::.|:.|:...|:..
Zfish  1685 ILVTLGMALLFIIRKKRKEKRLKRLRDAKSLAEMLISSKNNRSFDTPVKGPPQGPRLHIDIPRVQ 1749

  Fly  1698 ------------GYESRTLPGDYKEDHENRRNQQ----VYSASPVKTVDKGNESEMYEISP---- 1742
                        |.:..|:|....|..::...|.    |....|....:.|...:|.:|.|
Zfish  1750 LLIEDKEGIKQIGEDKATIPVTDTEFSQSVNPQSFCTGVSVHHPALIQNTGPLIDMSDIRPGTNP 1814

  Fly  1743 ---------YAT---FSVNGGRTGAPAKTPTRAVAAQTPLDYTMQFKTFGHPEGENLNATAYPLL 1795
                     ::|   :|.....|...|.||.|.:        |..::|.|...|..
Zfish  1815 VSRKSVKSAHSTRNRYSSQWTLTKCQASTPARTL--------TSDWRTVGSQHGIT--------- 1862

  Fly  1796 PSSGFGHVKSKSSWHKQRYYNTED-----ESTLSKSMTIVAGSQA-GHSKKSNGGRSAK------ 1848
                   |....|:......:|:.     .||.|.|.|....::| .|:|.....:.||
Zfish  1863 -------VTESDSYSASLSQDTDKGRNSMVSTESASSTYEELARAYEHAKLEEHLQHAKFEITEC 1920

  Fly  1849 ------SSAACSGVVAGSESDTSIS-PS---------------------------------TEFS 1873
                  |....:|....::|.||:| ||                                 :|:.
Zfish  1921 FISDSSSDQMTTGTNDNADSMTSMSTPSEPGICRFTASPPKPQDYDRGKNVAVPIPHRANKSEYC 1985

  Fly  1874 NMPTY-------------RVPC-------KSSRSSDGRAVVDMFRPDSSTESNNDQGSPAPERRH 1918
            |:|.|             ..||       .|.||...||.                        |
Zfish  1986 NLPLYMKTDPFFRKQAELHDPCPVVPPREASIRSLAARAY------------------------H 2026

  Fly  1919 NTPRHVL---GMGMAMGLGGGG-----GGGVGGGNGPAEKRSAGQRSRKHGSAAQQPSNQTLERR 1975
            ...||:.   ....|:.||.||     ..|..|.:||....:||..|...|:|       ||.:|
Zfish  2027 TQGRHMTLDPSKQQALTLGHGGLSSLTSSGASGTSGPPSSGAAGSSSISSGTA-------TLPQR 2084

  Fly  1976 KCPGSSNSLDSEVDAETAASLAASIAAMAGSGAGADLSGGFRPPAG 2021
            .....|.|         :.|.|.|.|..||:||.|..:||..|..|
Zfish  2085 TLTMPSTS---------STSSAPSGAVAAGAGASASSTGGSGPTPG 2121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam3	NP_996226.2	IG	56..133	CDD:214652	24/76 (32%)
		Ig	56..125	CDD:143165	23/68 (34%)
		I-set	246..337	CDD:254352	27/94 (29%)
		Ig	264..334	CDD:143165	21/69 (30%)
		I-set	345..433	CDD:254352	17/87 (20%)
		Ig	358..431	CDD:143165	15/72 (21%)
		Ig	456..533	CDD:143165	29/76 (38%)
		IGc2	553..619	CDD:197706	21/65 (32%)
		I-set	634..724	CDD:254352	40/90 (44%)
		ig	645..712	CDD:278476	29/67 (43%)
		IG_like	734..815	CDD:214653	27/88 (31%)
		Ig	745..815	CDD:299845	25/77 (32%)
		I-set	820..913	CDD:254352	29/95 (31%)
		Ig	838..920	CDD:299845	34/84 (40%)
		FN3	917..1033	CDD:238020	32/116 (28%)
		FN3	1040..1142	CDD:238020	31/104 (30%)
		fn3	1150..1237	CDD:278470	29/103 (28%)
		FN3	1263..1345	CDD:238020	23/81 (28%)
		Ig	1350..1436	CDD:299845	34/90 (38%)
		IG_like	1358..1436	CDD:214653	28/82 (34%)
		FN3	1441..1530	CDD:238020	28/89 (31%)
		FN3	1542..1620	CDD:238020	23/79 (29%)
dscaml1	XP_005157551.1	IG_like	112..184	CDD:214653	23/71 (32%)
		Ig	112..183	CDD:143165	23/70 (33%)
		Ig	194..287	CDD:299845	30/98 (31%)
		I-set	302..380	CDD:254352	24/82 (29%)
		IGc2	309..370	CDD:197706	20/65 (31%)
		IGc2	399..458	CDD:197706	14/63 (22%)
		I-set	477..571	CDD:254352	37/96 (39%)
		Ig	477..567	CDD:299845	35/92 (38%)
		IG_like	581..662	CDD:214653	25/83 (30%)
		IGc2	588..646	CDD:197706	20/60 (33%)
		Ig	684..751	CDD:143165	32/66 (48%)
		IG_like	686..756	CDD:214653	32/69 (46%)
		I-set	760..855	CDD:254352	30/94 (32%)
		Ig7_DSCAM	778..855	CDD:143211	25/76 (33%)
		IG_like	865..956	CDD:214653	29/90 (32%)
		Ig	873..963	CDD:299845	34/90 (38%)
		FN3	959..1053	CDD:238020	32/117 (27%)
		FN3	1060..1157	CDD:238020	31/104 (30%)
		FN3	1165..1271	CDD:238020	31/110 (28%)
		FN3	1276..1367	CDD:238020	30/93 (32%)
		IGc2	1392..1455	CDD:197706	24/63 (38%)
		FN3	1486..1559	CDD:238020	22/72 (31%)
		FN3	1573..1649	CDD:238020	24/81 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6933
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47134
OrthoDB	1	1.010	-	-		D10185at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6394
orthoMCL	1	0.900	-	-		OOG6_101656
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.830