DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cysu and TPO

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_024308853.1	Gene:	TPO / 7173	HGNCID:	12015	Length:	947	Species:	Homo sapiens

Alignment Length:	694	Identity:	227/694 - (32%)
Similarity:	337/694 - (48%)	Gaps:	123/694 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LLDISIQ-LARTYGLSYEEIEKGLPTIDTSKTLIREV-----CPPFFAGVE----CRPGKYRRFD 159
            :::.||| :.|...|..::.:.  ||...|:.|:..:     |.|:....:    |...|||...
Human   105 IMETSIQAMKRKVNLKTQQSQH--PTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPIT 167

  Fly   160 GLCNNIEHPTWGAANAPFQRLIGPLYSDGINAPR-----ISVTGRDLPFSRVVSR--------TM 211
            |.|||.:||.|||:|....|.:.|:|.||.:.||     ....|..||..|.|:|        .:
Human   168 GACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVV 232

  Fly   212 HPDDGFHDHAGTVMVIAWGQFMDHDFTLT---------GTPLDPINRNDPEECCKRPLHLKHPYC 267
            ..||.:.|     :::||||::|||...|         |...|          |:.....::| |
Human   233 TDDDRYSD-----LLMAWGQYIDHDIAFTPQSTSKAAFGGGAD----------CQMTCENQNP-C 281

  Fly   268 NEIRIPDDDYFYRLFNVKCIDFVRGFPSPRPGCKLGS-------------RQQFNTLTGVIDANT 319
            ..|::|::  ........|:.|.|.    ...|..|.             |||.|.||..:||:|
Human   282 FPIQLPEE--ARPAAGTACLPFYRS----SAACGTGDQGALFGNLSTANPRQQMNGLTSFLDAST 340

  Fly   320 VYGVKESFARKLR--TGYGGLMRMNPVFQEYGLKDLLPL-----------KLDIPDEGCTR-PNK 370
            |||...:..|:||  |...||:|::...::.| :..||.           :..||.|  || |
Human   341 VYGSSPALERQLRNWTSAEGLLRVHARLRDSG-RAYLPFVPPRAPAACAPEPGIPGE--TRGP-- 400

  Fly   371 SMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLFQEARRINIAIVQHVTF 435
               ||..|:.|.:|...||.:|||..|||||||.||..:|.||..:.::||||::..|:.|.:|.
Human   401 ---CFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITL 462

  Fly   436 NEFLPILLGKEVMEKFGLVLQKDGYWDGYDSTVNPGIIDSFAGAAFRFGHSLLPTAVERWS---K 497
            .:::|.:||.|..:::      .|.::|||||.||.:.:.|:.|||||||:.:...|.|..   :
Human   463 RDYIPRILGPEAFQQY------VGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQ 521

  Fly   498 AHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQVA--QAMDDSITQEVTNHLFKKEGARFGM 560
            .|..:....|......|:.|.|.|.||....||:.:.|  |..|..:.:|:|..||....:. .:
Human   522 EHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSS-TL 585

  Fly   561 DLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYGSMPNETVL-RYGSIFEHPADIDLWSGG 624
            ||.|.|:||||:.|:|||.|:|:|||||...|..::..::.:.:|. :...:::||.:||:|.||
Human   586 DLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGG 650

  Fly   625 VSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTD 689
            ::|..||.:..||.|||:|..||..||.||.||:|   ....||..|.:|:.|..|||:|||||.
Human   651 LAENFLPRARTGPLFACLIGKQMKALRDGDWFWWE---NSHVFTDAQRRELEKHSLSRVICDNTG 712

  Fly   690 L----IDTVQI--YPMVLPDHEINPRVPCKSGIIPSIDLTKWAD 727
            |    :|..|:  :|   .|.|     .|.|  |..::|..|.:
Human   713 LTRVPMDAFQVGKFP---EDFE-----SCDS--ITGMNLEAWRE 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	204/595 (34%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	152/401 (38%)
TPO	XP_024308853.1	thyroid_peroxidase	179..746	CDD:188657	205/616 (33%)
TPO	XP_024308853.1	CCP	754..807	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2660
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870