DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cysu and tpo

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	XP_021322945.1	Gene:	tpo / 569363	ZFINID:	ZDB-GENE-110519-2	Length:	672	Species:	Danio rerio

Alignment Length:	680	Identity:	216/680 - (31%)
Similarity:	327/680 - (48%)	Gaps:	101/680 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 QLARTYGLSYEEIEKGLPTIDTSKTLIREV----------------------------CPPFFAG 147
            :|:|......:::.:......|:.||::|.                            ||..|..
Zfish    24 RLSRRPSAETQQVSRSAEIFQTTLTLLKEKSSRRQRRSVQISEVLSVKAVERIANLSGCPRTFQS 88

  Fly   148 VECRPG-KYRRFDGLCNNIEHPTWGAANAPFQRLIGPLYSDGINAPRISVTGR-----DLPFSRV 206
            ..|... :||...|:|||.::|.||:||....|.:...|.||.|.|:....||     .||..|.
Zfish    89 TTCATDEEYRSITGVCNNRKNPFWGSANTGLARWLPAEYEDGENQPKGWNAGRQYNGFQLPPVRE 153

  Fly   207 VSRTMHPDDGF---HDHAGTVMVIAWGQFMDHDFTLTGTPLDPINRND----PEECCKRPLHLKH 264
            ||:.:......   .|...:.|::.|||::|||.:.|     |.:.:.    |...|.|......
Zfish   154 VSKRIIRSSSSALQEDRDYSQMLVDWGQYIDHDISFT-----PQSSSQTSFTPGFDCLRTCVSAD 213

  Fly   265 PYCNEIRIPDDDYFYRLFNVKCIDFVRGFPSPRPGCKLGSRQQFNTLTGVIDANTVYGVKESFAR 329
            | |..|:|..||...|  |..|:.|.|..||    |....|||.|::|..|||:||||..|...:
Zfish   214 P-CFPIQISRDDPLSR--NSSCLPFFRSSPS----CTGLQRQQLNSITSFIDASTVYGSSEEQQQ 271

  Fly   330 KLRTGYGGLMRMNPVFQEYGLKDLLPLKLDIPDEGCTRPNK------SMYCFEGGEIRVNEQLVL 388
            .||:. .||:.::..|.:.| :..||.....|.....:|..      .:.||..|:.||||.|.|
Zfish   272 ILRSS-TGLLAVSEEFWDTG-RPFLPSVPQRPSACLQQPGSPALLEARVECFAAGDSRVNEVLPL 334

  Fly   389 TCMHTLMAREHNRLATALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGL 453
            ..:|||..|||||||..|||||.||..:.::||.|:|..|:.|..|..:::|.::|:|.:.:|
Zfish   335 AVLHTLWMREHNRLAELLAQINTHWGKQRVYQETRKIIGALHQIFTMRDYIPKVIGQESVNEF-- 397

  Fly   454 VLQKDGYWDGYDSTVNPGIIDSFAGAAFRFGHSLLPTAVERWSKAHKFIASKRLSDLIRR----- 513
                .|.::||:.:|:|.:.:.||.|||||||..:...:.|.:::  |...:|...|..:
Zfish   398 ----LGPYEGYNESVDPSVSNVFATAAFRFGHVTISPYLRRLNQS--FQEDERYETLTLQQSFFS 456

  Fly   514 PYDLYRAGVLDEYFMGLMN--QVAQAMDDSITQEVTNHLFKKEGARFGMDLVSFNMQRGREFGIP 576
            |:.|.|.|.||.....|::  .|.|..:..:|:|:|..|......: .:||.:.|:||||:.|:|
Zfish   457 PWRLVREGGLDPVLRALLSAPAVLQDQEHLMTEELTERLLVLNVPQ-NLDLAALNLQRGRDHGLP 520

  Fly   577 GYMEFRKFCGLPTSNTWDE---MYGSMPNETVLRYGSIFEHPADIDLWSGGVSEKSLPGSMLGPT 638
            ||..:|.||||....:..:   :.||  ::.|.....::.||.::|:|.||:.|:.|.|:..||.
Zfish   521 GYNAWRVFCGLDRVESRSDLLKLVGS--DDLVKEIMDLYGHPDNVDVWLGGLLERPLSGARTGPL 583

  Fly   639 FACVIATQMSYLRRGDRFWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTDLIDTV------QIY 697
            |:|:|..||..||.|||||:   ..|..|:.||..|::...|||:||||:.|::..      ..|
Zfish   584 FSCLIGKQMKKLRDGDRFWW---LNPGVFSAEQRHELQTHSLSRVICDNSGLMEVPLDAFRRSSY 645

  Fly   698 PMVLPDHEINPRVPCKSGIIPSIDLTKWAD 727
            |   .|..:     |  |.:|::||..|.:
Zfish   646 P---EDFHL-----C--GSVPTLDLEAWRE 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	197/564 (35%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	143/397 (36%)
tpo	XP_021322945.1	An_peroxidase_like	113..665	CDD:326323	198/589 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010