DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cysu and Tpo

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_062226.2	Gene:	Tpo / 54314	RGDID:	3900	Length:	914	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	232/728 - (31%)
Similarity:	348/728 - (47%)	Gaps:	131/728 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NAAYLDARKRIHVAQPKSDWKPEELATVGEL-------------LLDISIQLAR-------TYGL 118
            ||.|...::.:   :.:....|.:|.:..:|             :::.|||:.:       |..|
  Rat    52 NAVYNTMKRNL---KKRGVLSPAQLLSFSKLPESTSGAISRAAEIMETSIQVMKREQSQFSTDAL 113

  Fly   119 SYEEIEKGLPTIDTSKTLIREVCPPFFAGVECRPGKYRRFDGLCNNIEHPTWGAANAPFQRLIGP 183
            |.:.    |.||......:..:.||..... |...|||...|:|||.:||.|||:|....|.:.|
  Rat   114 SADI----LATIANLSGCLPFMLPPRCPDT-CLANKYRPITGVCNNRDHPRWGASNTALARWLPP 173

  Fly   184 LYSDGINAPR-----ISVTGRDLPFSRVVSR--------TMHPDDGFHDHAGTVMVIAWGQFMDH 235
            :|.||.:.||     ....|..||..|.|:|        .:..||.:.|     .:..|||::||
  Rat   174 VYEDGFSQPRGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDDQYSD-----FLPVWGQYIDH 233

  Fly   236 DFTLTGTPLDPINRNDPEEC----------CKRPLHLKHPYCNEIRIPDDDYFYRLFNVKCIDFV 290
            |..||           |:..          |:.....::| |..|::|.:.    .....|:.|.
  Rat   234 DIALT-----------PQSTSTAAFWGGVDCQLTCENQNP-CFPIQLPSNS----SRTTACLPFY 282

  Fly   291 RGFPSPRPGCKLGS-------------RQQFNTLTGVIDANTVYGVKESFARKLR--TGYGGLMR 340
            |.    ...|..|.             |||.|.||..:||:||||......::||  :...||:|
  Rat   283 RS----SAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLR 343

  Fly   341 MNPVFQEYGLKDLLPL--KLDIPDEGCTRPNKSMYCFEGGEIRVNEQLVLTCMHTLMAREHNRLA 403
            :|.:..:.| :..||.  ....|:.|....|::. ||..|:.|.:|...|..:|||..|||||||
  Rat   344 VNTLHLDSG-RAYLPFASAACAPEPGAPHANRTP-CFLAGDGRASEVPALAAVHTLWLREHNRLA 406

  Fly   404 TALAQINKHWDDETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYDSTV 468
            ||...||.||...|.:||||::..|:.|.:|..:::|.:||.:...::      .|.::||:.||
  Rat   407 TAFKAINTHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQY------VGPYEGYNPTV 465

  Fly   469 NPGIIDSFAGAAFRFGHSLLPTAVERWS---KAHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGL 530
            ||.:.:.|:.|||||||:.:...|.|.:   :.|..:...:|.|:..||:.|.:.|.||....||
  Rat   466 NPTVSNVFSTAAFRFGHATVHPLVRRLNTDFQDHTELPRLQLHDVFFRPWRLIQEGGLDPIVRGL 530

  Fly   531 MNQVA--QAMDDSITQEVTNHLF--KKEGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSN 591
            :.:.|  |..:..:.:|:|..||  ...|.   :||.|.|:||||:.|:|||.|:|:||||....
  Rat   531 LARPAKLQVQEQLMNEELTERLFVLSNVGT---LDLASLNLQRGRDHGLPGYNEWREFCGLSRLE 592

  Fly   592 TWDEMYGSMPNETVL-RYGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRGDR 655
            |..|:..::.|.::: :...:::|..:||:|.||::||.|||:..||.|||:|..||..||.|||
  Rat   593 TPAELNKAIANRSMVNKIMELYKHADNIDVWLGGLAEKFLPGARTGPLFACIIGKQMKALRDGDR 657

  Fly   656 FWYELPNQPSSFTPEQLQEIRKAKLSRLICDNTDL----IDTVQI--YPMVLPDHEINPRVPCKS 714
            ||:|   ....||..|.||:.|..|.|:|||||.|    :|..:|  :|.   |.|     .|:.
  Rat   658 FWWE---NSHVFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQ---DFE-----SCEE 711

  Fly   715 GIIPSIDLTKWAD 727
              |||:||..|.:
  Rat   712 --IPSMDLRLWRE 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	201/588 (34%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	150/393 (38%)
Tpo	NP_062226.2	An_peroxidase	145..687	CDD:281139	198/580 (34%)
		thyroid_peroxidase	161..722	CDD:188657	204/609 (33%)
		CCP	730..783	CDD:153056
		EGF_CA	784..826	CDD:284955
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2513
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.870