DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cysu and MPO

DIOPT Version :9

Sequence 1:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster
Sequence 2:	NP_000241.1	Gene:	MPO / 4353	HGNCID:	7218	Length:	745	Species:	Homo sapiens

Alignment Length:	713	Identity:	232/713 - (32%)
Similarity:	343/713 - (48%)	Gaps:	132/713 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TYDAINAA-YLDARKRIHVA------QPKSDWK----PEELATVGELLLDISIQLARTYGLSYEE 122
            |..|:.|| ||      |||      :.:|.|:    ..::.|..:|.:     |:::.|.:|::
Human   109 TRTAVRAADYL------HVALDLLERKLRSLWRRPFNVTDVLTPAQLNV-----LSKSSGCAYQD 162

  Fly   123 IEKGLPTIDTSKTLIREVCPPFFAGVEC-RPGKYRRFDGLCNNIEHPTWGAANAPFQRLIGPLYS 186
            :                       ||.| ...|||...|:|||...||.||:|..|.|.:...|.
Human   163 V-----------------------GVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYE 204

  Fly   187 DGIN-----APRISVTGRDLPFSRVVSRTM--HPDDGF-HDHAGTVMVIAWGQFMDHDFTLTGTP 243
            ||.:     .|.:...|..:..:|.||..:  .|.|.. .|...::|.:.|||.:|||...|..|
Human   205 DGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEP 269

  Fly   244 ------LDPINRNDPEECCKRPLHLKHPYCNEIRIPDDDYFYRLFN-VKCIDFVRGFPSPRPGCK 301
                  :..:|   .|..|     ::.|.|..::||.:|  .|:.| ..||.|.|..|: .||..
Human   270 AARASFVTGVN---CETSC-----VQQPPCFPLKIPPND--PRIKNQADCIPFFRSCPA-CPGSN 323

  Fly   302 LGSRQQFNTLTGVIDANTVYGVKESFARKLR--TGYGGLMRMNPVFQEYGLKDLLPLKLDIPDEG 364
            :..|.|.|.||..:||:.|||.:|..||.||  :...||:.:|..||:.| :.|||.. ::.|:.
Human   324 ITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNG-RALLPFD-NLHDDP 386

  Fly   365 CTRPNKS--MYCFEGGEIRVNEQLVLTCMHTLMAREHNRLATALAQINKHWDDETLFQEARRINI 427
            |...|:|  :.||..|:.|.:|...||.||||:.||||||||.|..:|..||.|.|:||||:|..
Human   387 CLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVG 451

  Fly   428 AIVQHVTFNEFLPILLGKEVMEKFGLVLQKDGYWDGYDSTVNPGIIDSFAGAAFRFGHSLLPTAV 492
            |:||.:|:.::||::||...|.|:...      :..|:.:|:|.|.:.|.. |||:||:|:...:
Human   452 AMVQIITYRDYLPLVLGPTAMRKYLPT------YRSYNDSVDPRIANVFTN-AFRYGHTLIQPFM 509

  Fly   493 ERWSKAHKFIASKRLSDLIRRPYDLYRA---GVLDEYFMGLM---------NQVAQAMDDSITQE 545
            .|....::.:.......|.|..:..:|.   |.:|....|||         ||:|       ..|
Human   510 FRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIA-------VDE 567

  Fly   546 VTNHLFKKEGARFGMDLVSFNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYGSMPNETVLR--- 607
            :...|| ::..|.|:||.:.||||.|:.|:|||..:|:|||||...|..::      .||||
Human   568 IRERLF-EQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQL------GTVLRNLK 625

  Fly   608 --------YGSIFEHPADIDLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRGDRFWYELPNQP 664
                    ||:    |.:||:|.|||||.......:||..||:|.||...||.|||||:|   ..
Human   626 LARKLMEQYGT----PNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWE---NE 683

  Fly   665 SSFTPEQLQEIRKAKLSRLICDNTDLIDTVQIYPMVLPDHEINPRVPCKSGIIPSIDLTKWAD 727
            ..|:.:|.|.:.:..|.|:|||||. |.||....:.:.:......|.|.:  :|:::|..|.:
Human   684 GVFSMQQRQALAQISLPRIICDNTG-ITTVSKNNIFMSNSYPRDFVNCST--LPALNLASWRE 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	204/578 (35%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	151/408 (37%)
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	160/443 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150032
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750